T cells from strain 2 would respond to strain 13 cells due to alloreactivity between the different strains. B cells were used as target cells in Morrison and Braciale's experiments because B cells express both class I and class II MHC, allowing them to distinguish between the endogenous and exogenous antigen processing pathways using class I and class II MHC restricted T cells. Any cell type from the same animal could have been used but B cells are easy to obtain from blood.

1. In this test of T cells and macrophages from strain 2 , strain 13 , or F 1 guinea pigs, where would
you expect a T cell response due to alloreactivity? Select and/all correct answers. The
Requirement for Hislocompatible Macrophages in Antigen-Mediated DNA Synthesis in Immune
Guinea Pig Lymph Node Lymphocyles Why is is logical that Morrison and Braciale used B cells
as target cells/APC in their experiments distinguishing the endogenous and exogenous antigen
processing and presentation pathways? A. B cells are the only type of cell that can be recognized
by class I MHC restricted T cells B. any cell type from the same animal as the T cells could have
been used, but B cells are easy to obtain from blood C. B cells are the only type of cell that can
be recognized by class II MHC restricted T cells D. they needed target cells/APC that express
both class I and class II MHC