Where do endocyotic vesicles come from? A. Plasma membrance B. Nuclear membrance C. Smooth ER D. Lysosome Solution Answer: A. plasma membrane Reason: Cells are going to ingest fluid, molecules, and waste particles Clathrin mediated endocytosis result in internalization of the receptor further leading these receptors to be degraded by lysosomal endosome formation when there is not ligand to bound. This endocytosis process is going to produce endocytic vesicles from localized regions of the plasma membrane through invagination.