The current article is discussing about the role of SOX4 gene/protein in the metastasis, and tumourogenesis. Introduction:- SOX 4 is the transcription factor produces Sox4 protein in humans,which regulates the embryonic development and it directly invovles in the apoptosis regulation leading to the tumourogenesis. The malfunction of the gene results in the decreement of parathyroid hormone production so that bone desoption occurs. In the current study explain importance of the SOX 4 gene, the interdigital tissue is lysed by the apoptosis by the expression of SOX4 protein, so in the carcinoma cells, if we knock down of this gene causes the decreeased cell proliferation and induced apoptosis by activating caspases 3 and 7. It causes various carcinoma like example : Intra hepatitic metastatisis tissue, prostate cancer,lung cancer, colorectal cancer, breast cancer, myeloma,pineoblastoma, bladder cancer , gastric cancer. these all types are due high expression of SOX 4 gene(upregulation or over production). Solution The current article is discussing about the role of SOX4 gene/protein in the metastasis, and tumourogenesis. Introduction:- SOX 4 is the transcription factor produces Sox4 protein in humans,which regulates the embryonic development and it directly invovles in the apoptosis regulation leading to the tumourogenesis. The malfunction of the gene results in the decreement of parathyroid hormone production so that bone desoption occurs. In the current study explain importance of the SOX 4 gene, the interdigital tissue is lysed by the apoptosis by the expression of SOX4 protein, so in the carcinoma cells, if we knock down of this gene causes the decreeased cell proliferation and induced apoptosis by activating caspases 3 and 7. It causes various carcinoma like example : Intra hepatitic metastatisis tissue, prostate cancer,lung cancer, colorectal cancer, breast cancer, myeloma,pineoblastoma, bladder cancer , gastric cancer. these all types are due high expression of SOX 4 gene(upregulation or over production)..