1.THe biologically active form of Vit B12 is present in two forms. E.pdf

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1.THe biologically active form of Vit B12 is present in two forms. Either as methylcobalamin or adenosylcobalamin. Active form is measured as holotranscobalamin. 2. Intrinsic factor is produced by the parietal cells of the stomach. It is necessary for the absorption of dietary Vit B12. Deficiency of intrinsic factor results in pernicious anemia 3. R-protein binds to Vit B12 for the transport of the Vitamin-Protein complex. Solution 1.THe biologically active form of Vit B12 is present in two forms. Either as methylcobalamin or adenosylcobalamin. Active form is measured as holotranscobalamin. 2. Intrinsic factor is produced by the parietal cells of the stomach. It is necessary for the absorption of dietary Vit B12. Deficiency of intrinsic factor results in pernicious anemia 3. R-protein binds to Vit B12 for the transport of the Vitamin-Protein complex..

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Vitamin B12 is synthesized only by microorganisms and it is not present in plants Animals obtain the vitamin preformed from their natural bacterial flora or by eating foods derived from other animals Present in appreciable amounts in liver, red meat, fish, eggs , dairy products , and fortified cereals Required in humans for two essential enzymatic reactions Remethylation of homocysteine (Hcy) to methionine Isomerization of methylmalonyl coenzyme A (CoA), which is produced during the degradation of some amino acids (isoleucine, valine, threonine and methionine ) and fatty acids (FAs ) with odd numbers of carbon atoms DEFICIENCY When cobalamin is deficient, Fatty Acids accumulate and become incorporated into cell membranes , including those of the central nervous system (CNS) resulting in neurologic symptoms The physiologic coenzyme forms of cobalamin are 5'- deoxyadenosylcobalamin and methylcobalamin Folic acid (as N5-methyl THF) is also required in the remethylation of Hcy. Therefore , deficiency of B12 or folate results in elevated Hcy levels.

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/*****************VideoGame*****************/ public class VideoGame { // instance variables private String gameName; private String gameConsole; // Default constructor public VideoGame() { } // parameterized constructor public VideoGame(String gameName, String gameConsole) { this.gameName = gameName; this.gameConsole = gameConsole; } /* getters and setters */ public String getGameName() { return gameName; } public void setGameName(String gameName) { this.gameName = gameName; } public String getGameConsole() { return gameConsole; } public void setGameConsole(String gameConsole) { this.gameConsole = gameConsole; } } /****************VideoGameManager**************/ import java.io.BufferedReader; import java.io.FileOutputStream; import java.io.FileReader; import java.io.PrintWriter; import java.util.LinkedList; import java.util.Scanner; public class VideoGameManager { Scanner keyboard = new Scanner(System.in); //array list private LinkedList games; private LinkedList currentResult; //tab private static final String delim = \"\\t\"; //Default constructor public VideoGameManager(){ games = new LinkedList(); } public void ReadGameFile(String filePath) { //This reconstructs a new instance of the VideGame Linked list. //This is done to clear the Linked list games = new LinkedList(); BufferedReader br = null; try { //Create a new file Scanner //Scanner fileScanner = new Scanner(new File(fileName)); br=new BufferedReader(new FileReader(filePath)); String fileLine=\"\"; //Reads each line in the file one-by-one while((fileLine=br.readLine())!=null) { //That line is then split using the delimiter (\\t) String[] splitStrings = fileLine.split(delim); //If the newly created array is not 2 items in length then //that line is not correctly formatted and should be ignored. if(splitStrings.length != 2) continue; String gameName = splitStrings[0];//The first element is the game name String console = splitStrings[1];//Next is the console VideoGame newVideoGame = new VideoGame(gameName,console); games.add(newVideoGame);//Added to the Linked list } br.close(); } catch(Exception e) { System.out.println(e.getMessage()); } } public void WriteToGameFile(String fileName, boolean append) { if(games == null)//if the file name is null then return return; try { //Creates the new instance of a print writer PrintWriter fileWriter = new PrintWriter(new FileOutputStream(fileName,append)); for(VideoGame aVideoGame : games) { //Prints to the file fileWriter.println(aVideoGame.getGameName()+delim+ aVideoGame.getGameConsole()); } fileWriter.close(); } catch(Exception e) { System.out.println(e.getMessage()); } } //returns an array list of video games based on a search criterion (name and console) public void PrintSearchCriteria(String nameInput, String consoleInput) { currentResult=new LinkedList(); for(VideoGame aVideoGame : games) { String gameName=aVideoGame.getGameName().toLowerCase(); String consoleName=aVideoGame.getGameConsole().toLowerCase(); if(gameName.contains(nameInput.to.

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The RASopathies are a clinically defined group of medical genetic syndromes caused by germline mutations in genes that encode components or regulators of the Ras/mitogen-activated protein kinase (MAPK) pathway (Raue, 2013). Further, since theRASopathies: developmental syndromes of Ras/MAPK pathway results from duplication ofchromosomeband 12q24.11q24.23 it results in apparent ...X-linkedintellectual disability, (Michelson) Solution The RASopathies are a clinically defined group of medical genetic syndromes caused by germline mutations in genes that encode components or regulators of the Ras/mitogen-activated protein kinase (MAPK) pathway (Raue, 2013). Further, since theRASopathies: developmental syndromes of Ras/MAPK pathway results from duplication ofchromosomeband 12q24.11q24.23 it results in apparent ...X-linkedintellectual disability, (Michelson).

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The Broca\'s area is located in the frontal part of the brain on the left hemisphere. ... Thus, when Broca\'s aphasia occurs, it can have a debilitating effect on the person\'s communication skills. The damage forces people to speak in fragmented sentences that include only nouns and verbs. The Wernicke\'s area is located in the temporal lobe on the left side of the brain and is responsible for the comprehension of speech (Broca\'s area is related to the production of speech). ... When this area of the brain is damaged, a disorder known as Wernicke\'s aphasia can result The ventral stream is associated with object recognition and form representation. Also described as the \"what\" stream, it has strong connections to the medial temporal lobe(which stores long- term memories), the limbic system (which controls emotions), and the dorsal stream (which deals with object locations and motion).All the areas in the ventral stream are influenced by extraretinal factors in addition to the nature of the stimulus in their receptive field. These factors include attention, working memory, and stimulus salience. Thus the ventral stream does not merely provide a description of the elements in the visual world—it also plays a crucial role in judging the significance of these elements.Damage to the ventral stream can cause inability to recognize faces or interpret facial expression The function of the dorsal pathway is to map auditory sensory representations onto articulatory motor representations. Hickok & Poeppel claim that the dorsal pathway is necessary because, \"learning to speak is essentially a motor learning task. The primary input to this is sensory, speech in particular. So, there must be a neural mechanism that both codes and maintains instances of speech sounds, and can use these sensory traces to guide the tuning of speech gestures so that the sounds are accurately reproduced.Conduction aphasia affects a subject\'s ability to reproduce speech (typically by repetition), though it has no influence on the subject\'s ability to comprehend spoken language. This shows that conduction aphasia must reflect an impairment of the ventral pathway but instead of the dorsal pathway. Hickok and Poeppel found that conduction aphasia can be the result of damage, particularly lesions, to the Spt (Sylvian parietal temporal). This is shown by the Spt\'s involvement in acquiring new vocabulary, for while experiments have shown that most conduction aphasiacs can repeat high-frequency, simple words, their ability to repeat low-frequency, complex words is impaired. Hippocampal damage can result in anterograde amnesia: loss of ability to form new memories, although older memories may be safe. Thus, someone who sustains an injury to the hippocampus may have good memory of his childhood and the years before the injury, but relatively little memory for anything that happened since. Solution The Broca\'s area is located in the frontal part of the brain on the left hemispher.

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the conflict of internet surveilance versus individuals and privacy rights have been rage for years and mjor internet and technology companies including microsoft , google ,ebay and intel are seeking to update the electronic communication privacy act ie ECPA and the ECPA prevents internet service providers ie ISP\'s from releasing personal information including names ,addresses , phone numbers , credit card and account details about their subscribers without the court permission and protects the content of the files stored on individuals personal computers with the advent of the cloud storage and ubiquitous mobile phone usage since ECPA was passed in 1986 prosecutors and general public are at odds about whether police should be required to obtain a search warrant to retrieve an individuals email communications or to identify the location of smart phones or mobile devices so in this way and yes the congress should enact laws requiring isp\'s to formally track their customers activities in attempt to aid police investigating crimes , attorneys litigating divorce and insurance fraud cases and the entertainment industry in locating illegally downloaded files like tracking the hacker so inorder to protect the information from the hackers congress enacted these laws. Solution the conflict of internet surveilance versus individuals and privacy rights have been rage for years and mjor internet and technology companies including microsoft , google ,ebay and intel are seeking to update the electronic communication privacy act ie ECPA and the ECPA prevents internet service providers ie ISP\'s from releasing personal information including names ,addresses , phone numbers , credit card and account details about their subscribers without the court permission and protects the content of the files stored on individuals personal computers with the advent of the cloud storage and ubiquitous mobile phone usage since ECPA was passed in 1986 prosecutors and general public are at odds about whether police should be required to obtain a search warrant to retrieve an individuals email communications or to identify the location of smart phones or mobile devices so in this way and yes the congress should enact laws requiring isp\'s to formally track their customers activities in attempt to aid police investigating crimes , attorneys litigating divorce and insurance fraud cases and the entertainment industry in locating illegally downloaded files like tracking the hacker so inorder to protect the information from the hackers congress enacted these laws..

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Please find the summary below: Contemporary geographical conditions reveal alot about the primitive states of fauna and flora. In this regard, a very discrete observation has been made with respect to diversion and evolution of fauna and flora of Central America. During past few decades, it has been observed that a close association occurs between the reproductive traits of flora and the nature of fauna found in Central American lowland forest areas. Researchers have observed that in last few centuries, some large herbivore species have become extinct. There extinction has lead to significant decline in the seed-dispersal and cross-pollination efficacy of the local plants of this area. However, inhabitation of humans and colonization has resulted into rearing of large cattles such as horses in these areas. The rearing of these large herbivores has played a crucial role in restoring the floral diversity in these areas because these herbivores help in seed-dispersal and sexual reproduction of plants by grazing and movements. Conseqeuntly, these observations has lead to recognize the impact and capability of restoration of local extinct/near-extinct floral diversity just by merely introducing large/small herbivores. Thus, a comparative analysis could be made between artifical methods of floral-diversity restoration as compared to natural and environmentally favourable methods. Solution Please find the summary below: Contemporary geographical conditions reveal alot about the primitive states of fauna and flora. In this regard, a very discrete observation has been made with respect to diversion and evolution of fauna and flora of Central America. During past few decades, it has been observed that a close association occurs between the reproductive traits of flora and the nature of fauna found in Central American lowland forest areas. Researchers have observed that in last few centuries, some large herbivore species have become extinct. There extinction has lead to significant decline in the seed-dispersal and cross-pollination efficacy of the local plants of this area. However, inhabitation of humans and colonization has resulted into rearing of large cattles such as horses in these areas. The rearing of these large herbivores has played a crucial role in restoring the floral diversity in these areas because these herbivores help in seed-dispersal and sexual reproduction of plants by grazing and movements. Conseqeuntly, these observations has lead to recognize the impact and capability of restoration of local extinct/near-extinct floral diversity just by merely introducing large/small herbivores. Thus, a comparative analysis could be made between artifical methods of floral-diversity restoration as compared to natural and environmentally favourable methods..

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Correlation is the key in diversification of risk. If one asset does well, the other does not. Therefore, adding assets that do not behave like other assets in your portfolio is good and can reduce risk. The two companies should have a correlation of less than 1.0. Even when we expand the portfolio to many assets, correlation among assets remains the primary determinant of portfolio risk. Lower correlations are associated with lower risk. Unfortunately, most assets have high positive correlations. The challenge in diversifying risk is to find assets that have a correlation that is much lower than +1.0. For Diversified portfolios investor must have domestic stocks, domestic bonds, foreign stocks, foreign bonds, real estate, cash, and other asset classes.The low correlations between stocks and bonds are attractive for portfolio diversification. Similarly, including international securities in a portfolio can also control portfolio risk Solution Correlation is the key in diversification of risk. If one asset does well, the other does not. Therefore, adding assets that do not behave like other assets in your portfolio is good and can reduce risk. The two companies should have a correlation of less than 1.0. Even when we expand the portfolio to many assets, correlation among assets remains the primary determinant of portfolio risk. Lower correlations are associated with lower risk. Unfortunately, most assets have high positive correlations. The challenge in diversifying risk is to find assets that have a correlation that is much lower than +1.0. For Diversified portfolios investor must have domestic stocks, domestic bonds, foreign stocks, foreign bonds, real estate, cash, and other asset classes.The low correlations between stocks and bonds are attractive for portfolio diversification. Similarly, including international securities in a portfolio can also control portfolio risk.

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Ans.) Exosomes are layer enclosed vesicles effectively discharged into the extracellular space, whose substance reflects the physiological condition of the cells they begin from. These vesicles are involved in cell-to-cell correspondence and exchange of naturally dynamic proteins, lipids, and RNAs. A ) Molecular composition of virus-modified exosomes- Exosomes are basically cytoplasm encased in a lipid bilayer with uncovered at the outside of transmembrane proteins. Exosomes may contain a wide range of biomolecules like proteins, sugars, lipids and furthermore nucleic acid also. New sanitization strategies giving exceedingly immaculate arrangements of exosomes have permitted the utilization of proteomic and atomic systems to comprehend the sub-atomic piece of exosomes. B) Both the virus-modified exosomes and typical eukaryotic cell membrane is made up of lipid bilayer. The chemical composition of both the mentioned entities is almost same as both of them are composed of proteins, sugars, lipids and nucleic acid. Exosomes are found inside the eukaryotic cell, they are derived from the eukaryotic cell. C) These virus-modified exosomes are used to target the RNA delivery, a new advancement in the field of nanomedicine. Recent studies propose that a specific type of nano-sized lipid vesicles called exosomes can consolidate and transport useful RNAs into target cells and may serve as an appealing option. Confirmation is gathered that most pluricellular organism maintains exosome- based interchanges by means of transfer between mRNA and miRNAs between the cells. We found that viruses have discovered approaches to endeavor this correspondence. We talk about disclosures in exosome biogenesis their physical properties, focusing on and transport methodologies and how the information of exosome creation in virus tainted cells could impel their entrance into clinical trials. Solution Ans.) Exosomes are layer enclosed vesicles effectively discharged into the extracellular space, whose substance reflects the physiological condition of the cells they begin from. These vesicles are involved in cell-to-cell correspondence and exchange of naturally dynamic proteins, lipids, and RNAs. A ) Molecular composition of virus-modified exosomes- Exosomes are basically cytoplasm encased in a lipid bilayer with uncovered at the outside of transmembrane proteins. Exosomes may contain a wide range of biomolecules like proteins, sugars, lipids and furthermore nucleic acid also. New sanitization strategies giving exceedingly immaculate arrangements of exosomes have permitted the utilization of proteomic and atomic systems to comprehend the sub-atomic piece of exosomes. B) Both the virus-modified exosomes and typical eukaryotic cell membrane is made up of lipid bilayer. The chemical composition of both the mentioned entities is almost same as both of them are composed of proteins, sugars, lipids and nucleic acid. Exosomes are found inside the eukaryotic cell, they are derived.

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(a).Let me show that H is a subgroup. Then you can make the identical argument and show that K is. e = (e, e) is in H let (x, e) be in H. G1 group so x^-1 in G1. Now (x^-1, e) = (x,e)^-1 since (x, e)(x^-1, e) = (xx^- 1, e) = (e, e) which is the identity in G let (x, e), (y, e) be in H. Then (x,e)(y,e) = (xy,ee) = (xy,e) is in H. Therefore H is a subgroup of G b) Let me show that KH=G. You can make the identical argument to show that HK=G. Let k =(e, y) be in K, h=(x, e) in H. Then kh = (e,y)(x,e) = (ex,ye)=(x,y) is in G, so KH subset of G Let (x,y) be in G. Then (e,y) is in K and (x,e) is in H, and (e,y)(x,e) = (x,y). So G is a subset of KH. Therefore G=KH Solution (a).Let me show that H is a subgroup. Then you can make the identical argument and show that K is. e = (e, e) is in H let (x, e) be in H. G1 group so x^-1 in G1. Now (x^-1, e) = (x,e)^-1 since (x, e)(x^-1, e) = (xx^- 1, e) = (e, e) which is the identity in G let (x, e), (y, e) be in H. Then (x,e)(y,e) = (xy,ee) = (xy,e) is in H. Therefore H is a subgroup of G b) Let me show that KH=G. You can make the identical argument to show that HK=G. Let k =(e, y) be in K, h=(x, e) in H. Then kh = (e,y)(x,e) = (ex,ye)=(x,y) is in G, so KH subset of G Let (x,y) be in G. Then (e,y) is in K and (x,e) is in H, and (e,y)(x,e) = (x,y). So G is a subset of KH. Therefore G=KH.

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ASSETS 2016 2015 Current assets: Cash 3251 3407 Accouns receivable 4777 5801 Inventory 12438 13802 Total current assets 20466 23010 Fixed assets: Net plant and equipment 49749 74097 Total assets 70215 97107 LIABILITIES & OWNERS\' EQUITY Current liabilities: Accounts payable 2143 2580 Other 88 105 Notes payable 1740 2096 3971 4781 Long term debt 13600 16360 Total debt 17571 21141 Owners\' equity: Common stock and paid in surplus 37000 37000 Accumulated earnings 15644 38966 Total owners\' equity 52644 75966 Total liabilities and owners\' equity 70215 97107 Current ratio = Current assets/Current liabilities = 5.15 4.81 (20466/3971) (23010/4781) Quick ratio = (Cash+Accounts receivable)/Current liabilities = 2.02 1.93 (3251+4777)/3971)) (3407+5801)/4781)) Cash ratio = (Cash+marketable securities)/Current liabilities 0.82 0.71 (3251/3971) (3407/4781) Total asset turnover = Sales/Average total assets = 186970/((70215+97107)/2)) = 2.23 Inventory turnover = Cost of goods sold/Average inventory = 126003/((12438+13802)/2)) = 9.60 Receivables turnover = Sales/Average receivables = 186970/((4777+5801)/2)) = 35.35 Total debt ratio = Total debt/Total assets 0.25 0.22 Debt equity ratio = Total debt/Total equity 0.33 0.28 Equity multiplier =Total assets/Total equity 1.33 1.28 Times interest earned = EBIT/Interest expense = 55614/1450 = 38.35 Cash coverage ratio = (EBIT+Depreciation)/Interest expense = (55614+5353)/1450 = 42.05 Profit margin = Net income/Sales = 35207/186970 = 18.83% Return on assets = Net income/Average assets = 35207/((70215+97107)/2)) = 42.08% Return on equity = Net income/Average equity = 35207/((52644+75966))/2) = 54.75% Solution ASSETS 2016 2015 Current assets: Cash 3251 3407 Accouns receivable 4777 5801 Inventory 12438 13802 Total current assets 20466 23010 Fixed assets: Net plant and equipment 49749 74097 Total assets 70215 97107 LIABILITIES & OWNERS\' EQUITY Current liabilities: Accounts payable 2143 2580 Other 88 105 Notes payable 1740 2096 3971 4781 Long term debt 13600 16360 Total debt 17571 21141 Owners\' equity: Common stock and paid in surplus 37000 37000 Accumulated earnings 15644 38966 Total owners\' equity 52644 75966 Total liabilities and owners\' equity 70215 97107 Current ratio = Current assets/Current liabilities = 5.15 4.81 (20466/3971) (23010/4781) Quick ratio = (Cash+Accounts receivable)/Current liabilities = 2.02 1.93 (3251+4777)/3971)) (3407+5801)/4781)) Cash ratio = (Cash+marketable securities)/Current liabilities 0.82 0.71 (3251/3971) (3407/4781) Total asset turnover = Sales/Average total assets = 186970/((70215+97107)/2)) = 2.23 Inventory turnover = Cost of goods sold/Average inventory = 126003/((12438+13802)/2)) = 9.60 Receivables turnover = Sales/Average receivables = 186970/((4777+5801)/2)) = 35.35 Total debt ratio = Total debt/Total assets 0.25 0.22 Debt equity ratio = Total debt/Total equity 0.33 0.28 Equity multiplier =Total assets/Total equity 1.33 1.28 Times interest earned = EBIT/Interest expense = 55614/.

ASSETS 2016 2015 Current assets Cash 3251 3407 Accouns re.pdf

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ACA (Affordable care Act) signed by Obama on 23 march 2010. Putting Information for Consumers Online So that consumers can compare health insurance coverage options and pick the coverage that works for them. Prohibiting Denying Coverage of Children Based on PreExisting Conditions The health care law includes new rules to prevent insurance companies from denying coverage to children under the age of 19 due to a pre-existing condition. Prohibiting Insurance Companies from Rescinding Coverage In the past, insurance companies could search for an error, or other technical mistake, on a customer\'s application and use this error to deny payment for services when he or she got sick. But now this is illegal. After media reports cited incidents of breast cancer patients losing coverage, insurance companies agreed to end this practice immediately. Eliminating Lifetime Limits on Insurance Coverage Insurance companies will be prohibited from imposing lifetime dollar limits on essential benefits, like hospital stays. Regulating Annual Limits on Insurance Coverage Insurance companies\' use of annual dollar limits on the amount of insurance coverage a patient may receive will be restricted for new plans in the individual market and all group plans. In 2014, the use of annual dollar limits on essential benefits like hospital stays will be banned for new plans in the individual market and all group plans. Appealing Insurance Company Decisions Provides consumers with a way to appeal coverage determinations or claims to their insurance company, and establishes an external review process. Establishing Consumer Assistance Programs in the States States that apply ACA receive federal grants to help set up or expand independent offices to help consumers navigate the private health insurance system. These programs help consumers file complaints and appeals; enroll in health coverage; and get educated about their rights and responsibilities in group health plans or individual health insurance policies. The programs will also collect data on the types of problems consumers have, and file reports with the U.S. Department of Health and Human Services to identify trouble spots that need further oversight. Improving Quality and lowering costs Both this head get amended from time to time so that consumer receive best to best service. Increasing Access to Affordable Care Hoe ACA Affects Reiumburshment Short Term Effects: The most immediate expected effect of the ACA for providers is a sudden rise in patient populations. Millions of Americans are expected to obtain coverage under the ACA Payers are required to cover more than ever,under the ACA, individual and small group health plans are required to cover 10 essential health benefits Long Term Effects: Changing payment and care models,biggest changes in healthcare right now are the new fee-for- value payment models that are replacing traditional fee-for-service programs Through Medicare and Medicaid, the government has been .

ACA (Affordable care Act) signed by Obama on 23 march 2010. .pdf

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we have, V1 T1= V2T2 Volume = V2 = 12.126 lit.pdf

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Should just be proportional .0951.28=x1 .074=.pdf

annaistrvlr

only C represents the pair of resonance structure.pdf

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