ethosomes

1. ETHOSOME AS NOVEL DRUG DELIVERY SYSTEM
DEPARTMENT OF PHARMACEUTICS
Presented BY- Ankit Sharma
ROLL NO-05
P.D.E.A’s S.G.R.S college of Pharmacy Saswad

2. CONTENTS
•Introduction
•Definition
•Composition
•Mechanism of action
•Advantages & Disadvantages
•Characterization
•Method of preparation
•Application
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3. INTRODUCTION
• Why we need NDDS?
• What is NDDS?
• What are the approaches used in NDDS?
• Why TDDS ?
• What is vesicular system?
• What is Ethosomes?

4. DEFINITION
Ethosomes are non-invasive delivery carriers
that enable drugs to reach the deep skin
layers and/or the systemic circulation.
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5. STRUCTURE OF ETHOSOMES
5
.
Scanning electron micrograph of optimized formulation of Rabeprazol
ethosomes

6. COMPOSITION
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Sr.
no
Class Example Uses
1.
Phospholipid
s
Soya Lecithin Vesicles forming component
2.
Polyglycol Propylene
glycol
As a skin penetration
enhancer
3.
Alcohol Ethanol For providing the softness
for vesicle membrane
4.
Dye Rhodamine red For characterization study
5.
Vehicle Carbopol D934 As a gel former

7. MECHANISM OF ACTION
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8. ADVANTAGES
1. Delivery of large molecules (peptides) is
possible.
2. It contains non-toxic raw material in
formulation.
3. Ethosomal drug delivery system can be
applied widely in pharmaceutical veterinary,
cosmetic fields.
4. Ethosomes enhance permeation of the drug
through skin transdermal & dermal
delivery.
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9. DISADVANTAGES
1. Poor Yield.
2. Loss of product during transfer from organic
to water media.
3. Drug that require high blood levels can not
be administrated- limited only to potent
molecules, those requiring a daily dose of
10mg or less.
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10. CHARACTERIZATION
1. Vesicle shape
2. Vesicle size and Zeta potential
3. Drug entrapment
4. Transition temperature
5. Drug content
6. Stability study
7. Skin penetration study
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11. Method of Preparation
1. Cold method
2. Hot method
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12. 12

13. Application
1.Delivery of Antiviral drugs
2.Topical delivery of DNA
3.Transdermal delivery of Hormones.
4.Delivery of Anti-parkinsonism agent
5.Transcellular Delivery
6.Delivery of Anti-Arthritis Drugs
7.Delivery of Problematic drug molecules
8.Delivery of Antibiotics
9.Delivery of Antigen loaded Drugs
10.Delivery of NSAIDS
11.Widely used in Cosmoceuticals
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