This document discusses the ethical challenges facing anti-doping regulations as human genetic engineering and enhancement technologies advance. It provides a timeline of key developments from 1999-2017 showing how gene doping became a reality in the early 2000s, leading to its inclusion in anti-doping codes by 2004. However, recent technologies like gene editing, ingestible enhancements, and advanced prosthetics now allow the general public to potentially surpass athletes in physical capabilities, calling into question the social mandate of anti-doping rules. The conclusion asks how anti-doping can continue protecting athletes when non-athletes may achieve superior performance through enhancement.