MAO inhibitors should be contraindicated with dairy (milk containing) products
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Advertisement. If you take an MAOI and you eat high-tyramine foods, tyramine can quickly reach dangerous levels. This can cause a serious spike in blood pressure and require emergency treatment. Avoid consuming foods that are high in tyramine if you take an MAOI.
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MAO inhibitors should be contraindicated with dairy (milk containing) products
- 1. MAO inhibitors should be contraindicated with Tyramine rich food Prof. Amol B.Deore Department of Pharmacology MVP’s Institute of pharmaceutical Sciences, Nashik Email: amol_deore@rediffmail.com
- 2. Learning Outcome You will be able to understand Depression disorder Action of MAO inhibitors Action of Tyramine Tyramine rich food products Tyramine and MAO inhibitor interaction
- 3. Depression (major depressive disorder) • mood disorder • persistent feeling of sadness and loss of interest, • it affects how you feel, think and behave • emotional and physical problems • trouble doing normal day-to-day activities • life isn't worth living
- 4. Causes of depression • low levels of the Monoamine Neurotransmitters • Serotonin, dopamine, and norepinephrine Monoamine and Catecholamines
- 7. Monoamine Oxidase enzyme • family of enzymes that catalyze the oxidation of monoamines • outer membrane of mitochondria in most cell types of the body • serve to inactivate monoamine neurotransmitters MAO-A • Metabolism of NA, DA and Serotonin (5-HT) MAO-B • DA (Dopamine) and Phenylethylamine
- 8. MAO Inhibitors FDA has approved these MAOIs to treat depression • Isocarboxazid • Phenelzine • Selegiline • Tranylcypromine
- 9. Mechanism of action of MAO inhibitors MAO inhibitors site of action
- 10. Tyramine • Amino acid • normal constituent of many foods • chemically related to noradrenaline • interfere with storage of NA in nerve terminals • Increase release of the catecholamine (monoamines)
- 11. MAO inhibitors + Tyramine rich food MAO-A inhibitor Tyramine rich food Increase Catecholamine Release Hypertensive crisis
- 12. MAO inhibitors should be contraindicated with tyramine rich dairy products
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