Since the cell making cortisol has a high concentration of cortisol compared to outside the cell, that cell will use ___ (facilitated diffusion, primary active transport, simple diffusion, bulk transport, secondary active transport) to move that cortisol from inside, where it was made in the ___ (smooth ER, nucleus, rough ER, lysosome, mitochondria), to outside of that cell. The cells of your adrenal medulla might be releasing large amounts of epinephrine - a large, hydrophilic, catecholamine - into your blood all at the same time using ___ (simple diffusion, exocytosis, primary active transport, facilitated diffusion, pinocytosis, phagocytosis, secondary active transport)..