Integration of synaptic signaling is a. the area under the curve of postsynaptic (graded) potentials overlapping in time and space. b. the command signals for central pattern generators. c. a spontaneous activity in pacemaker neurons. d. the temporal and/or spatial summation of postsynaptic (graded) potentials. Solution d. the temporal and/or spatial summation of postsynaptic (graded) potentials. Integration of synaptic signalling indicates the number of neuronal signals or synaptic signals that integrate to produce either the excitatory postsynaptic potential (EPSP) or the inhibitory postsynaptic potential (IPSP). Spatial summation involves the synaptic inputs from several neurones. Sometimes, two or more EPSPs occur at a single synapse, one after another, but before the post synaptic membranes potential has not returned to the normal resting potential. In such cases, the EPSPs add together, and this is called “temporal summation.”.