Clinico-Pathological Conference Date: 9-9-2021

1. • 2.5%-15.4% of primary brain tumors;
• 44% of all brain tumor patients
• More common in frontal lobe tumors;
• specifically left-sided
• Depression must be distinguished from
apathy;
• Which is associated with a functional
disconnection between the frontal lobe and
paralimbic areas, or damage in these areas
doi: 10.5498/wjp.v5.i3.273

2. CPC-09092021

3. Depression
Anxiety
Stress
Immediate threats
Psychomotor agitation
Past losses
Psychomotor retardation
Future threats

4. Grief
Adjustment
Disorder
Persistent
Depressive
Disorder
Major
Depressive
Disorder
SPECIFIER
Melancholic
Atypical
Peripartum
Anxious
Seasonal
Psychotic
Catatonic
Mixed
Depressive disorder
due to another
medical condition
Substance-induced
Major
depression part
of another
mental disorder
SEVERITY
Mild
Moderate
Severe

5. • Gene-Environment
Interaction model
• 3 major monoamine
systems—serotonin,
norepinephrine and
dopamine
• Role of Stress,
Inflammation, and the
Neuroendocrine System
https://doi.org/10.1016/j.psc.2011.12.001