PPT Presentation

1. IONTOPHORESIS
PRESENTED BY
KANKARIYA YASH P.
SIR.DR. M.S. GOSAVI COLLEGE OF PHARMACEUTICAL EDUCATION AND
REASERCH, NASHIK -05

2. DEFINATION
• Iontophoresis can be defined as the permeation
of ionized drug molecule across biological drug
membranes under the influence of electric
current.
• Facilitated movement of ions across a skin
(membrane) under the influence of an externally
applied small electrical potential difference.

3. ADVANTAGES OF IONTOPHORESIS
• Virtually painless when properly applied.
• Provides option for patients unable to receive
injection.
• Reduced risk of infection due to non invasive nature.
• Treatments are completed in very less time.
• Medications are directly deliverd at the treatment
site.

4. DRAWBACKS OF IONTOPHORESIS
• Ionic form of drug in sufficient concentration is
necessary for iontophoretic delivery.
• Burns are caused by the electrolytic changes in the
tissue.
• Electric shocks may cause by high current density at the
skin surface.
• The high current density and the time of application
would generate extreme pH, resulting in chemical burn.

5. MECHANISM

6. MECHANISM
• The basic principle of iontophoretic drug delivery is that
like charges repel like charges so the drug ions are
repelled or pushed into the underlining tissue.
• When direct DC current is applied to an ionized drug
solution, the ions that have the same charge as the
electrode are repelled by electrode and are delivered
through the skin.
• Sweat ducts are primary paths by which ions pass
through skin.

7. • A negatively charged drug delivery electrode transports
the negative drug ions into underlying tissues.
• A positively charge drug delivery electrodes transport
positive drug ions into the skin.

8. • Transport of drugs across the skin involves either diffusion,
migration or electro osmosis.
• Electro osmosis is the bulk flow of fluid occurring in the same
direction as the flow of counter ions when a voltage difference is
applied across a charged, porous membrane.
• This flow involves motion of fluid without concentration gradient
and is significant factor affecting Iontophoresis.

13. FACTORS AFFECTING IONTOPHORESIS
• Operational factors
• Concentration of drug solution
• pH of donor solution
• Ionic strength
• Presence of Co-ions
• Molecular size and weight
• Polarity
• Intra and Inter subject variability

15. THANK YOU