3. HIV has high affinity for
CD4+ T lymphocytes and
monocytes.
• HIV ties to CD4+ cells
and becomes disguised.
The infection imitates itself
by creating a DNA duplicate
by turn around transcriptase.
• Viral DNA gets joined
into the host DNA,
empowering further
replication.
4. In 1982, the term Acquired Immune
Deficiency Syndrome is utilized just
because. The name was assigned by the
CDC.
In 1983, French researchers at the
Institute Pasteur found another infection
that they called lymph denopathy-related
infection or LAV.
About a year later, Dr. Robert Gallo, of the
National Cancer Institute found HLTV-III.
The principal disclosure was made in
France at the Institute Pasteur, however
shared credit is given to Dr. Robert Gallo,
the pioneer of AIDS and his French
partners for finding HIV on April 23, 1984.
5.
6.
7.
8. • It targets T lymphocytes. So all the
resistant actuation halted.
• If resistant actuated, it will murders the T
cells, due to of HIV in it.
• Main saint's of safe cells as
MACROPHAGE, WBCs get tainted.
• No immunological memory framed.
9. ●Destruction of CD4+ T cells population
●Immune effects due to HIV infection
●Progression of HIV infection to AIDS
10. CELLULAR IMMUNITY
CD8+ T cells
Early:
Development of escape
mutants.
Late:
Apoptosis-Expression of
PDI molecule.
Malfunctional CD8+ T
cells.
HUMORAL IMMUNITY
Neutralizing Antibodies
Hypervariabiling of
Primary sequence of the
envelope.
Extensive Glycosylation of
the envelope.
Conformational masking
of the neutralizing
epitopes.