This presentation contains the definition of drugs, stereochemistry, chirality, effects of chirality on drugs and examples

1. Stereochemistry of Drugs
PRESENTED BY,
YAMUNA.R ,
II –M.SC. BIOTECHNOLOGY,
ANNAMALAI UNIVERSITY.

2. SYNOPSIS……….
 Drug – introduction.
 Stereochemistry.
 Chirality of drugs.
 Drug stereochemistry.
 Drug action.
 References.

3. DRUG
 Chemical or biological substances.
 Single compound or mixture of different compounds.
 Prevent or cure disease.
 FDA approved – legal drugs

4. STEREOCHEMISTRY
 Sub discipline of chemistry.
 Study – spatial arrangement of atoms that forms the structure of the molecules
and their manipulation.
 Focuses – stereoisomers .
 Same molecular formula and sequence of bonded atoms , but differs in the three
– dimensional orientation of their atoms in space.
 3D chemistry.

5. CHIRALITY OF DRUGS
 Fundamental property of 3D object.
 Important biological property resides on stereoisomerism.
 Same molecular formula , same functional group , different 3D orientation.
 Minor change in the drug molecular structure , major change in pharmacological
properties.
 Right and left handed molecules interact with living systems in very different ways.

8. DRUG STEREOCHEMISTRY
 Ibuprofen
 Thalidomide
 Metamphetamine
 Amphetamine

9. IBUPROFEN STEREOCHEMISTRY
 1 chiral atom.
 2 enantiomers.
 It is an optically active compound .
 S and R isomers.
 S – dextrorotatory – more biologically active

10. 3D STRUCTURE

11. BIOLOGICAL EFFECTS
 (S) Enantiomer – effective in reducing fever and pain relief.
 (R) Enantiomer – no side effect

12. METAMPHETAMINE
 2 enantiomers .
 D – methamphetamine and L- methamphetamine.
 Street drug known as crystal meth – D- methamphetamine.
 Vicks vapour inhalers – L – methamphetamine.

14. DRUG ACTION
 The effecetiveness of a drug is often related to the chemical structure and polarity of the
substances.

16. REFERENCES
 http://www.yourgenome.org/facts/how-are-drugs-designed-developed.
 http://rxcinternational.com/different/types.
 http://pubmed.ncbi.nlm.nih.gov.
 http://juniperpublishers.com/role-of-chirality-in-drugs.
 https://chemistry-Europe.onlinelibrary.wiley.com.
 https://pubs.acs.org/doi.
 https://www.slideshare.com/stereochemistry-on-drugs.