This document discusses cholesteatoma and chronic suppurative otitis media (CSOM). It defines cholesteatoma as the presence of keratinizing squamous epithelium in the middle ear or mastoid. Theories on the origin of cholesteatoma include retraction of the tympanic membrane or migration of squamous epithelium through a perforation. CSOM is a long-standing middle ear infection characterized by discharge and permanent perforation. It is classified as tubotympanic or atticoantral, with atticoantral being more dangerous due to higher risk of complications like cholesteatoma and bone erosion. Treatment involves surgical removal of disease or conservative management
2. CONTENTS
Cholesteatoma
Origin
Classification
Expansion of
cholesteatoma &
destructive of bone
Chronic suppurative
otitis media(CSOM)
Epidemiology
Types
Clinical features
Investigations
Treatments
3.
4. presence of keratinizing squamous
epithelium in the middle ear or
mastoid
“skin in the wrong place”
2 parts
Matrix
Central white mass
DEFINITION
6. ORIGIN OF
CHOLESTEATOMA
Wittmaack’s theory
Invagination of TM
from the attic/
posterosuperior part
of pars tensa in the
form of retraction
pockets
Ruedi’s theory
Basal cell
hyperplasia
Proliferate- infection,
lay down
keratinizing
squamous
epithelium (KSE)
7. ORIGIN OF
CHOLESTEATOMA
Habermann’s theory
Epithelial invasion
From the meatus/
outer drum surface
Pre-existing
perforation(marginal
)- part of the annulus
tympanicus-
destroyed
Sade’s theory
Metaplasia
Like respiratory
mucosa elsewhere
d/t repeated
infection
squamous
9. CONGENITAL
CHOLESTEATOMA
Embroyonic epidermal cell rests in the middle
ear cleft/ temporal bone
Middle ear, petrous apex, cerebellopontine
angle
Middle ear: white mass behind an intact
tympanic membrane conductive hearing loss
Discovered: routine exam/myringotomy
May spontaneously rupture- TM discharging
ear
10. PRIMARY ACQUIRED
CHOLESTEATOMA
No h/o previous OM/ pre-existing perforation
Invagination of pars flaccida
Persistent negative pressure in the attic
retraction pocket which accumulates keratin
debris.
Infected expand middle ear
Basal cell hyperplasia
Proliferation of the basal layers of PF induced by
subclinical childhood infection
Squamous metaplasia
Normal pavement epithelium of attic undergoes
metaplasia, keratinizing squamous epithelium
11. SECONDARY ACQUIRED
CHOLESTEATOMA
Already a pre-existing perforation in pars
tensa
Associated with posterosuperior marginal
perforation
Migration of squamous epithelium
KSE of EAC/ outer surface of TM migrates
through the perforation into the middle ear
Metaplasia: repeated infections of middle ear-
pre-existing perforation
12. EXPANSION OF
CHOLESTEATOMA AND
DESTRUCTION OF BONE
Enter the middle ear cleft invades the
surrounding structures
Attic cholesteatoma: extend backwards into
the aditus, antrum, mastoid. Downwards into
the mesotympanum; medially, it may surround
the incus and/or head of malleus.
Destroy bone, ear ossicles, erosion on bony
labyrinth
Enzymes : collagenase, acid phosphatase,
proteolytic enzymes(osteoclast, mononuclear
inflammatory cells)
13. Long standing infection of a part or whole of
the middle ear cleft characterized by ear
discharge and permanent perforation
CHRONIC SUPPURATIVE
OTITIS MEDIA (CSOM)
17. TUBOTYMPANIC-
SAFE/BENIGN
It involves the
anteroinferior part of
middle ear
Often associated with
central perforation
There is no risk of
serious complications
AETILOLOGY
Sequela of AOM-
following
exanthematous fever,
leaving behind a large
central perforation
Ascending infection
via the ET- recurring
otorrhoea
Persistent mucoid
otorrhoea: allergy to
ingestants
18. TUBOTYMPANIC-
SAFE/BENIGN
PATHOLOGY
Perforation of pars
tensa
Middle ear mucosa-
oedematous/velvety
Polyp- pale
Ossicular chain-
intact, mobile,may
show necrosis
Tympanosclerosis
Fibrosis and
adhesions
BACTERIOLOGY
Aerobics:
pseudomonas
aeruginosa, Proteus,
E.coli, Staph aureus
Anaerobes:
Bacteroids fragilis,
anaerobic
Streptococci
19. TUBOTYMPANIC-
SAFE/BENIGN
CLINICAL
FEATURES
Ear discharge
Nonoffensive,mucoid
, mucopurulent
Hearing loss
Conductive
Perforation
Always central
Middle ear mucosa
Perforation is large,
pale pink,moist
INVESTIGATIONS
Examination under
microscope
Audiogram
Culture and
sensitivity of ear
discharge
Mastoid X-ray/CT
scan temporal bone
20. TREATMENT
Aural toilet
remove all discharge
and debris by dry
mopping, suction
clearance or
irrigation
Ear drops
antibiotics ear drops
containing neomycin,
polymyxin,
chloromycetin, or
gentamycin +
steroids
Systemic antibiotics
useful in acute
Precautions
keep water out of
ear, rubber inserts
use
Treatment of
contributory causes-
such as infected
tonsils, adenoids,
maxillary antra and
nasal allergy
Surgical : remove
aural polyps/
granulations
Reconstructive
21. ATTICOANTRAL-
UNSAFE/DANGEROUS
Posterosuperior part
of the cleft
Associated with an
attic/marginal
perforation
Bone-eroding
process:
cholesteatoma,
granulation/osteitis
Risk of
complications is
higher
AETIOLOGY AND
BACTERIOLOGY
Same with
tubotympanic
22. PATHOLOGY
o Cholesteatoma
o Osteitis and granulation tissue
o Osteitis involves outer attic wall, posterosuperior
margin of tympanic ring
o Granulation tissue surrounds it may even fill the attic,
antrum, posterior tympanum, mastoid
o Fleshy red polypus: meatus
23. PATHOLOGY
o Ossicular necrosis
o Destruction may be limited to the long process of
incus, may also involves stapes superstucture, handle
of malleus/ entire ossicular chain
o Greater hearing loss
o Cholesteatoma hearer
o Cholesterol granuloma
o Mass of granulation tissue with foreign body giant cells
surrounding the cholesterol crystals.
24. SYMPTOMS
Ear discharge
• Scanty,foul smelling
• Total cessation of discharge- seriously
Hearing loss
• Normal: ossicular chain is intact
• Conductive type
Bleeding
• Granulation/polyps
• Cleaning
25. SIGNS
PERFORATION
• Either attic or posterosuperior marginal type
• can be missed due to crust
RETRACTION
POCKET
• Invagination of TM is seen in the attic/
posterosuperior part of PT
• Early: shallow,self cleansing Later:
deep,acumulation of keratin mass,infected
CHOLESTEATOMA
• Pearly white flakes can be sucked from the
retraction pocket
Grade Description
I Slight retracted TM, not touching incus
II Deep retraction, touching incus, middle ear mucosa not
affected
III Middle ear atelectasis. It lies on the promontory, ossicles
IV Also called Adhesive otitis media where TM becomes
adherent to promontory
26. INVESTIGATIONS
Examination under microscope. May reveal
presence of cholesteatoma, evidence of bone
destruction etc
Tuning fork test & audiogram
X-ray mastoids/CT temporal. Attic and antrum
destruction caused by cholesteatoma best
seen lateral in CT.
Culture and sensitivity of discharge
27. FEATURES INDICATING
COMPLICATIONS IN CSOM
Pain.; extradural, perisinus or brain abscess and
sometimes otitits externa
Vertigo: erosion of lateral semicircular canal
Persistent headache: intracranial involvement
Facial weakness: facial canal
Listless child with refusal of feeding: extradural
abscess
Fever,nausea,vomiting: IC infection
Irritability & neck rigidity: menigitis
Diplopia : (Gradenigo syndrome) petrositis
Ataxia: labyrinthitis/cerebellar abscess
Abscess around the ear: mastoiditis
29. SURGICAL
Primary aim is to
remove disease,
render ear safe
Secondary aim to
preserve or
reconstruct hearing
CWD:
Mastoid cavity open
Diseased area is fully
exteriorized
Atticotomy,modified
radical
mastoidectomy, RM
CWU
Approach by meatus,
mastoid but retained
the posterior bony
meatal wall intact
Dry ears, permits easy
reconstruction of
hearing mechanism
CANAL WALL UP CANAL WALL DOWN
MEATUS Normal appearance Widely open meatus
communicating with mastoid
DEPENDENCE Does not require routine
cleaning
Dependence on DR for
cleaning mastoid cavity
once/twice a year
RECURRENCE/
RESIDUAL SX
High rate- cholesteatoma Low rate
2ND LOOK
SURGERY
Require: after 6months of
surgery/rule out
cholesteatoma
Not required
PATIENTS
LIMITATIONS
No. can swim Swimming infection of
mastoid cavity
AUDITORY
REHABILITATIO
N
Easy to wear a hearing
aid if needed
Problems in fitting d/t large
meatus & infected mastoid
cavity
31. CONSERVATIVE TREATMENT
Cholesteatoma is small, easily accesible to
suction clearance under microscope
Elderly >65 years old
Unfit for GA/ refused
Polyps,granulation tissue: cup forceps/ cauterized
by chemical agents (silver nitrate/ trichloroacetic
acid)
Aural toilet, dry ear precautions
32. CONCLUSION
TUBOTYMPANIC/SAFE ATTICOANTRAL/UNSAFE
DISCHARGE Profuse, mucoid odourless Scanty, purulent, foul smelling
PERFORATION Central Attic/marginal
GRANULATION
S
Uncommon Common
POLYPS Pale Red and fleshy
CHOLESTEATO
MA
Absent Present
COMPLICATIO
NS
Rare Common
AUDIOGRAM Mild to moderate
conductive deafness
Conductive/mixed deafness
33. REFERENCES
Diseases of ear, nose, throat and head & neck
surgery, PL Dhingra 6th edition,page 65-74