I have given a description and structural explanation of gluconeogenesis cycle.

1. Microbial physiology
Gluconeogenesis
1
Chinnathambi S M.Sc.,
Microbiologist
chinnaselvamc345@gmail.com

2. 01 Introduction
Precursors
02
03
04
05
Location/site of reaction
Pathway
Reactions
Contents
2

3. Gluconeogenesis
3
Gluco- Glucose Neo-New Genesis-Synthesis
Synthesis of glucose from Non-carbohydrate compounds/precursors.
Occur mainly during hypoglycemic conditions / when liver
exhausted its supply of glycogen.
“Glucagon hormone” regulates gluconeogenesis

4. :
Precursors
4
Lactate
Pyruvate
Amino acids
Propionate
Glycerol
Acetate

5. Location/site of reaction
 It primarily occur in liver cells and also occur in the cells of kidney.
 The process starts in the mitochondria of the cells by pyruvate to oxaloacetate.
 Ends with the production of glucose in the cytoplasm of the cell.
5

6. 6
Pathway

7. Reactions
7
1) Pyruvate to phosphoenol pyruvate (PEP)
+ H2O
+CO2

8. 2) PEP to 2-phosphoglycerate
8
3) 2-phosphoglycerate to 3-phosphoglycerate

9. 9
4) 3-phosphoglycerate to 1,3-bisphosphoglycerate
5) 1,3-bisphosphoglycerate to G-3-P

10. 10
6) G-3-P to Fructose 1,6-bisphosphate
7) Fructose 1,6-bisphosphate to Fructose-6-phosphate

11. 11
8) Fructose-6-phosphate to Glucose-6-phosphate
9) Glucose-6-phosphate to Glucose

12. Conclusion/Significance
 Maintenance of blood glucose levels.
 Metabolic flexibility.
 Conservation of muscle protein.
 Regulation of fatty acid metabolism
12

13. Thank you 
13