2015 innovation day_hyperspectral camera_verhaert & lambda-x

Hyperspectral camera technology & applications
Template Innovation Day presentationCONFIDENTIAL
HYPERSPECTRAL CAMERA:
HOW TO GROW IN THE MEDICAL
MARKET AS AN OUTSIDER ?
Olivier DUPONT Thierry EMERAUD
CEO Lambda-X Business Developer Verhaert
odupont@lambda-X.com thierry.emeraud@lverhaert.com
MEDICAL: CONVERGENCE IN HEALTH CARE

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CONFIDENTIAL
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CONTENT
Medical market for an outsider
Lambda-X context
Hyperspectral at Lambda-X: a 13 years journey from space
Landing onto the medical ecosystem
Towards a Proposition Value
Conclusion

CONFIDENTIAL
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MEDICAL MARKET: MULTIFACETED & MULTIPLE TRENDS
140 million people with Alzheimer in 2050
Age related macular degeneration
8% of the WW population having diabetes …50% not aware of it!
Infectious diseases (Ebola) H1N1 pandemic
Early cancer detection
Personalized Healthcare
Surgery guidance
Point-Of-Care testing (near patient testing)
Prevention instead of healing
Tele monitoring
Gene therapy

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CONFIDENTIAL
A GLOBAL TREND FOR CONVERGENCE
imaging

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CONFIDENTIAL
• Belgian Company founded in 1996
• 100% Private Belgian shareholders
• Established in Nivelles since 2004
• Member of the Verhaert Group since 2014
LAMBDA-X CONTEXT

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CONFIDENTIAL
LAMBDA-X BUSINESS MODEL
• Concept & Design
• Prototyping
• Serial Production
• Scientific instruments
• Earth observation
• Space exploration
• Solar pointers
• Metrology tailored to
ophthalmic markets
• Spectacles
• Contact lenses
• Intraocular lenses
AEROSPACE OPTICS SUPPORT TO INDUSTRY OPHTHALMICS
CONCEPT / PROJECTS
SERIAL PRODUCTS

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CONFIDENTIAL
SOME LAMBDA-X CUSTOMERS
Confidential
SPACE DEFENSE
INDUSTRY
OPHTHALMICS

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CONFIDENTIAL
HYPERSPECTRAL TECHNOLOGY
1. Acquiring the 3D data cube (XY) at once
2. Hyperspectral = high spatial & spectral resolutions simultaneously
• detectors are 2D only…

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CONFIDENTIAL
HYPERSPECTRAL AT LAMBDA-X
A 13 YEARS JOURNEY FROM SPACE
2002 ESA: explore future biological Lab in Space.
Conclusion: go “confocal” and enable “fluorescence studies”
2005 Miniaturized confocal microscope (AMME
project).
Excite biological tissues at 1 & measure at 2 & 3
2007 Hyperspectral function for confocal microscope
(ACMO)
2009 New ESA project “Intelligent spectroscopic
device coupled with high-speed cameras” for
chemical analysis of the re-entry of space
(ISDE)
2012 HYPE camera
HYPEMI project (UCL, de Duve)
2014 Collaboration with GIGA/ULg
2015 Doing business in biology
3µM BODIPY-
GlcCer

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CONFIDENTIAL
FUNDAMENTAL LEARNINGS FROM THE SPACE ODYSSEY
1. Miniaturization
(3 steps optics development)
A compact, flexible and robust imaging instrument
that can adapt to microscopes for biology applications.
Footprint
/ 3.5 (m²)
/ 8 (m³)
3. Reliability
2. Modularity

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CONFIDENTIAL
Diagnostics /
point-of-care
Patient
(Home)
Anatomo-
pathologists
Hospital
Doctor
Academic
research
IVD
companies
Pharmaceu-
ticals
Centers for
human
genetics
LANDING WITH HYPE IN
THE MEDICAL ECOSYSTEM

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CONFIDENTIAL
HYPERSPECTRAL FOR THE BIOLOGIST
RELATES TO FLUORESCENCE
• Fluorescence: absorbing light at exc and re-emitting light at em
• Fluorescent molecules: auto fluorescent proteins (GFP) or
organic probes that are used as biomarkers for
• Cell nucleus (DAPI)
• Cell parts (cytoplasmic membrane)
• Antibodies primary and secondary (AlexaFluor 488)
• Proteins
• DNA/chromosomes (FISH), etc…
• Fluorescence is impacted by environmental factors enabling
advanced studies on bio-organisms
• Fluorescence is a reference technique for biologists:
epifluorescence microscopes

CONFIDENTIAL
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HOW TO TACKLE THE
EXPECTATIONS IN
THE BIOLOGY MARKET ?

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CONFIDENTIAL
INTEGRATED PRODUCT INNOVATION
Technology & IP
development
Proof of principle
Prototype
development
Demonstration
First series
Validating process
Product &
business
strategy
Directing innovation
Strategic design
Value capturing
Product
documentation
training
Product launch
Strategic innovation
services FEI
Product development
services NPD
Pre-launch
services NPI
Hybrid
collaboration
models
CONSULTANCY
INSOURCING
OUTSOURCING
TRAINING
TECHNICAL TRACK
BUSINESS TRACK
USER
CENTERED

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CONFIDENTIAL
PRODUCT SHARPENING: MANY POTENTIAL DIFFERENTIATORS
HIGHLOW LOWHIGH
must haves rivals
indifferent outperformers
DESIRABILITY
High spectral
resolution
Ease-of-use
Flexible
can be mounted on
any microscope
Affordable
UTILITY
Fast enough
for vital imaging
Photon
contrast
Accreditation

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CONFIDENTIAL
TOWARDS AN INNOVATIVE VALUE PROPOSITION ?
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affordability
ease-of-use
acrreditationSpectral resolution
photon contrast
Epifluorescence microscope Confocal microscope (laser scan)
HYPE camera (Lambda-X)
Value against
confocal
Value against
epifluo

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CONFIDENTIAL
GO TO MARKET STRATEGY
1. Biological market: largest growth for optical microscopy
2. Make the story happen…
• Find the appropriate niche where to anchor (identified)
• Leverage on killer applications (FISH, protein colocalisation,…)
• Work closely with the academic world: UCL, ULg, ULB, UGent, UHasselt,… (on-going)
3. Build our own learning curve
• Fail fast
• Learn fast
• Reduce uncertainties
• Manage the risk
4. Market creation: barriers ?

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CONFIDENTIAL
DEVELOP ON THE APPLICATION SIDE
Pharma-
ceuticals
Ex-Vivo
analysis
Surgery tissue
imaging
Protein co-
localisation
Cancer
detection
Cell therapies
Genetic
analysis
Molecular
interactions
FISH

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CONFIDENTIAL
LANDING SOMEWHERE ELSE WITH HYPE IN THE FUTURE ?
Food sorting
Crops
pathogens
Paint
Plastic
manufacturing
Water
treatment
Gas
combustion
flame
Recycling
(plastic)
UAV
(agriculture)

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CONFIDENTIAL
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CONCLUSION
Tech transfer from space
Numerous applications in the biological world
Usage aspects are value drivers beyond technology
Several market spots next to biology
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Develop in a non existing market
Is our vision on user value correct ? (assessment)
Next market spot besides biology ?
Open innovation model of Verhaert + Lambda-X hyperspectral technology = USP ?
What did we learn?
Unknowns and potential pitfalls

Kruibeke
Belgium
Verhaert New Products & Services
Hogenakkerhoekstraat 21
B-9150 Kruibeke
T +32 3 250 19 00
E info@verhaert.com
www.verhaert.com
Nivelles
Belgium
Noordwijk
Netherlands
Lambda-X
Avenue Robert Schuman 102
B-1400 Nivelles
T +32 67 47 57 10
E info@lambda-x.com
www.lambda-x.com
Verhaert Netherlands
Kapteynstraat 1
2201 BB Noordwijk
T +31 71 760 05 50
E info@verhaert.com
connect.verhaert.com
INDUSTRYFMCGCONNECT
MEDICAL TECHXFER
MEDICALAEROSPACE
TECHXFER
FMCGCONNECT
TECHXFER
Aveiro
Portugal
Load Interactive
Av. Dr. Lourenço Peixinho 15
3800-159 Aveiro
T +351 234 604 088
E info@load-interactive.com
www.load-interactive.com
CONNECT
Masters in Innovation is the innovation platform of Verhaert
to inspire and coach professionals on product and business
development and management.
Innovation Day is an initiative of Verhaert Masters in Innovation.

2015 innovation day_hyperspectral camera_verhaert & lambda-x

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