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What is diabetes?
 Diabetes is a serious life-long health condition that occurs when
the amount of glucose (sugar) in the blood is too high because the
body can’t use it properly. If left untreated, high blood glucose
levels can cause serious health complications.
 There are two main types of diabetes:Type 1 andType 2.They’re
different conditions, caused by different things, but they are both
serious and need to be treated and managed properly
Type 1 diabetes (Insulin Dependent Diabetes Mellitus)
•Type 1 diabetes is an autoimmune condition where the body attacks and destroys
insulin-producing cells, meaning no insulin is produced. This causes glucose to
quickly rise in the blood.
•Nobody knows exactly why this happens, but science tells us it’s got nothing to do
with diet or lifestyle.
•About 10 per cent of people with diabetes have Type 1.
Type 2 diabetes (Non- Insulin Dependent Diabetes Mellitus)
•In Type 2 diabetes, the body doesn’t make enough insulin, or the insulin it makes
doesn’t work properly, meaning glucose builds up in the blood.
•Type 2 diabetes is caused by a complex interplay of genetic and environmental
factors. Up to 58 per cent of Type 2 diabetes cases can be delayed or prevented
through a healthy lifestyle.
•About 90 per cent of people with diabetes have Type 2.
There are a range of more rare types of diabetes – correct diagnosis and
management of these types are equally important.
A chronic condition in which the pancreas produces little or no insulin.
(IDDM)
A chronic condition that affects the way the body processes blood sugar (glucose).
NIDDM
 Alternative to these synthetic agents, plants provided a
potential source of hypoglycemic drugs and are
widely used in several traditional systems of medicine
to prevent diabetes. Several medicinal plants have been
investigated for their beneficial effect in different type
of diabetes.
 Since the synthetic agents used for treatment of diabetes
cause long term complications and side effects hence
Natural products came into existence which is supposed to
delay the complications with reduced side effects thereby
making the life of diabetic people a lot easier.
1 Aerial parts Artemisia pallens, Bidens pilosa, Bixa orellana,Teramnus labialis
2 Bark Cinnamomum zeylanicum, Croton cajucara
3 Bulb Allium cepa, Allium sativum
4 Flower Cassia auriculata,Gentiana olivier, Musa sapientum
5 Fruit Carum carvi,Coriandrum sativum, Embellica officinalis, Juniperus communis, Momordica charantia,Xanthium strumarium
6 Leaves Aloe barbadensis,Annona squamosa, Averrhoa bilimbi,Azadirachta indica, Beta vulgaris, Camellia sinensis, Cassia alata, Eclipta
alba, Eucalyptus globulus, Euphrasia officinale, Ficus carica,Gymnema sylvestre,Gynura procumbens, Ipomoea aquatica,
Mangifera indica, Myrtus communis, Memecylon umbellatum, Morus indica,Ocimum sanctum
7 Rhizome Nelumbo nucifera
8 Roots Clausena anisata, Glycerrhiza glabra, Helicteres isora, Pandanus odorus
9 Seed AcaciaArabica,Agrimony eupatoria, Lupinus albus, Luffa aegyptiaca, Lepidium sativum, Mucuna pruriens, Punica granatum
10 Stem Amaranthus spinosus, Coscinium fenestratum
11 Tubers Ipomoea batata
12 Whole plant Abies pindrow,Achyranthus aspera,Ajauga iva,Aloe vera,Anacardium occidentale,Andrographis paniculata,Capsicum
frutescens, Cryptolepis sanguinolenta, Enicostemma littorale, Ficus religiosa
Plant botanical
name
Common name Family Mechanism of action
1. Acacia arabica Babool Leguminosae Release of insulin from pancrease
2. Aloe barbadensis Gheequar Liliaceae Stimulating synthesis and release of
insulin
3. Boerhaavia
diffusa
Punamava Nyctaginaceae Increase plasma insulin
concentration
4. Camellia sinensis Green tea Theaceae Increase insulin secretion
5. Capsicum
frutescens
Mirch Solanaceae Increase insulin secretion and
reduction of insulin binding on the
insulin receptor
6. Cinnamomum
zeylanicum
Dalchini Lauraceae Elevation in plasma insulin level
7. Eucalyptus
globulus
Eucalyptus Myrtaceae Increase insulin secretion from
clonal pancreatic beta line.
8. Hibiscus rosa Gudhal Malvaceae Stimulate insulin secretion from
beta cells
9. Swertia chirayata Chirayata Gentianaceae Stimulates insulin release from
islets
10. Vinca rosea Sadabahar Apocynaceae Beta cell rejuvenation, regeneration
and stimulation
11. Zingiber officinale Adrak Zingiberaceae Increase insulin level and decrease
fasting glucose level
Plants having Insulin mimetic and insulin secreatory activity
Azadirachta indica(NEEM) Ocimum sanctum(TULSI)
Stevia rebaudiana (Stevia) Allium sativum (Garlic)
Aloe vera (Aloe- emodin)
Curcuma longa (Turmeric)
Bahunia variegate (OrchidTree)
 Annona squamosa (Sugar- Apple)
 Nigella sativa (Kalongi)
 Curcuma longa (Curcumin)
 α- tocopherol
 Ascorbic Acid (Amla)
 Aronia melanocarpa (Black chokeberry)
 Momordica (Karela)
 Fenugreek (Methi)
 Black Plum (Jamun seed powder)
 Gymnema (Gurmar leaves)
Quinic acid (Black chokeberry) Kalongi (Nigella sativa)
References:rereREFERENCES:
 https://www.diabetes.org.uk/diabetes-the-basics ( Site visited on6th April)
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609288/bv (viewed on 7th April)
 http://slideplayer.com/slide/8786097/ (visited on 7th April)
 http://www.omicsonline.org/open-access/medicinal-plants-with-potential-
antidiabetic-activity-and-their-assessment-2167-0412.1000151.php?aid=23652 (7th
April)
 https://www.omicsonline.org/a-review-of-recent-investigations-on-medicinal-
herbs-possessing-anti-diabetic-properties-jndt.1000102.php?aid=2192
 https://www.sciencedirect.com/science/article/pii/S1471489203000687 (7th April)
 https://www.medicalnewstoday.com/info/diabetes (7th April)
 www.nutraingridients-usa.com/Articles (7th April)
 Ijpsr.com (7th April)
 Easyayurveda.com (7th April)
Antidiabetics

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Antidiabetics

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  • 2. What is diabetes?  Diabetes is a serious life-long health condition that occurs when the amount of glucose (sugar) in the blood is too high because the body can’t use it properly. If left untreated, high blood glucose levels can cause serious health complications.  There are two main types of diabetes:Type 1 andType 2.They’re different conditions, caused by different things, but they are both serious and need to be treated and managed properly
  • 3. Type 1 diabetes (Insulin Dependent Diabetes Mellitus) •Type 1 diabetes is an autoimmune condition where the body attacks and destroys insulin-producing cells, meaning no insulin is produced. This causes glucose to quickly rise in the blood. •Nobody knows exactly why this happens, but science tells us it’s got nothing to do with diet or lifestyle. •About 10 per cent of people with diabetes have Type 1. Type 2 diabetes (Non- Insulin Dependent Diabetes Mellitus) •In Type 2 diabetes, the body doesn’t make enough insulin, or the insulin it makes doesn’t work properly, meaning glucose builds up in the blood. •Type 2 diabetes is caused by a complex interplay of genetic and environmental factors. Up to 58 per cent of Type 2 diabetes cases can be delayed or prevented through a healthy lifestyle. •About 90 per cent of people with diabetes have Type 2. There are a range of more rare types of diabetes – correct diagnosis and management of these types are equally important.
  • 4. A chronic condition in which the pancreas produces little or no insulin. (IDDM)
  • 5. A chronic condition that affects the way the body processes blood sugar (glucose). NIDDM
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  • 13.  Alternative to these synthetic agents, plants provided a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. Several medicinal plants have been investigated for their beneficial effect in different type of diabetes.  Since the synthetic agents used for treatment of diabetes cause long term complications and side effects hence Natural products came into existence which is supposed to delay the complications with reduced side effects thereby making the life of diabetic people a lot easier.
  • 14. 1 Aerial parts Artemisia pallens, Bidens pilosa, Bixa orellana,Teramnus labialis 2 Bark Cinnamomum zeylanicum, Croton cajucara 3 Bulb Allium cepa, Allium sativum 4 Flower Cassia auriculata,Gentiana olivier, Musa sapientum 5 Fruit Carum carvi,Coriandrum sativum, Embellica officinalis, Juniperus communis, Momordica charantia,Xanthium strumarium 6 Leaves Aloe barbadensis,Annona squamosa, Averrhoa bilimbi,Azadirachta indica, Beta vulgaris, Camellia sinensis, Cassia alata, Eclipta alba, Eucalyptus globulus, Euphrasia officinale, Ficus carica,Gymnema sylvestre,Gynura procumbens, Ipomoea aquatica, Mangifera indica, Myrtus communis, Memecylon umbellatum, Morus indica,Ocimum sanctum 7 Rhizome Nelumbo nucifera 8 Roots Clausena anisata, Glycerrhiza glabra, Helicteres isora, Pandanus odorus 9 Seed AcaciaArabica,Agrimony eupatoria, Lupinus albus, Luffa aegyptiaca, Lepidium sativum, Mucuna pruriens, Punica granatum 10 Stem Amaranthus spinosus, Coscinium fenestratum 11 Tubers Ipomoea batata 12 Whole plant Abies pindrow,Achyranthus aspera,Ajauga iva,Aloe vera,Anacardium occidentale,Andrographis paniculata,Capsicum frutescens, Cryptolepis sanguinolenta, Enicostemma littorale, Ficus religiosa
  • 15. Plant botanical name Common name Family Mechanism of action 1. Acacia arabica Babool Leguminosae Release of insulin from pancrease 2. Aloe barbadensis Gheequar Liliaceae Stimulating synthesis and release of insulin 3. Boerhaavia diffusa Punamava Nyctaginaceae Increase plasma insulin concentration 4. Camellia sinensis Green tea Theaceae Increase insulin secretion 5. Capsicum frutescens Mirch Solanaceae Increase insulin secretion and reduction of insulin binding on the insulin receptor 6. Cinnamomum zeylanicum Dalchini Lauraceae Elevation in plasma insulin level 7. Eucalyptus globulus Eucalyptus Myrtaceae Increase insulin secretion from clonal pancreatic beta line. 8. Hibiscus rosa Gudhal Malvaceae Stimulate insulin secretion from beta cells 9. Swertia chirayata Chirayata Gentianaceae Stimulates insulin release from islets 10. Vinca rosea Sadabahar Apocynaceae Beta cell rejuvenation, regeneration and stimulation 11. Zingiber officinale Adrak Zingiberaceae Increase insulin level and decrease fasting glucose level Plants having Insulin mimetic and insulin secreatory activity
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  • 22. Stevia rebaudiana (Stevia) Allium sativum (Garlic) Aloe vera (Aloe- emodin)
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  • 26.  Annona squamosa (Sugar- Apple)  Nigella sativa (Kalongi)  Curcuma longa (Curcumin)  α- tocopherol  Ascorbic Acid (Amla)  Aronia melanocarpa (Black chokeberry)  Momordica (Karela)  Fenugreek (Methi)  Black Plum (Jamun seed powder)  Gymnema (Gurmar leaves)
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  • 31. Quinic acid (Black chokeberry) Kalongi (Nigella sativa)
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  • 33. References:rereREFERENCES:  https://www.diabetes.org.uk/diabetes-the-basics ( Site visited on6th April)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609288/bv (viewed on 7th April)  http://slideplayer.com/slide/8786097/ (visited on 7th April)  http://www.omicsonline.org/open-access/medicinal-plants-with-potential- antidiabetic-activity-and-their-assessment-2167-0412.1000151.php?aid=23652 (7th April)  https://www.omicsonline.org/a-review-of-recent-investigations-on-medicinal- herbs-possessing-anti-diabetic-properties-jndt.1000102.php?aid=2192  https://www.sciencedirect.com/science/article/pii/S1471489203000687 (7th April)  https://www.medicalnewstoday.com/info/diabetes (7th April)  www.nutraingridients-usa.com/Articles (7th April)  Ijpsr.com (7th April)  Easyayurveda.com (7th April)