Techniques for characterization of particle,

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2. BHARATI VIDYAPEETH COLLEGE OF PHARMACY,
KOLHAPUR.
Department of Pharmaceutics
2015-2016
Guided by;
Dr. N. R. Jadhav
Professor & Head
Dept. of Pharmaceutics
Presented by;
Mr. Tukaram S. Patil
M. Pharm. (Sem- I)
Dep. Of Pharmaceutics
“TECHNIQUES FOR CHARACTERIZATION OF SOLID
PARTICLE”
SEMINAR ON,
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3. CONTENT :
 Introduction to characterization of solid
 Techniques for particle size measurement
 Particle shape measurement
 Surface area measurement
 Conclusion
 Reference
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INTRODUCTION
 The oral aspect is considered to be most convenient for
administration of drugs to Patients
 Normally dissolve in stomach fluid and intestinal fluid absorb
from these regions of GIT
 Localized drug delivery to colon it need to be protected from
upper GIT environment
 Targeted drug delivery to colon for various disease like ulcerative
colitis, colonic cancer etc.
 Colon targeting drug delivery capable of protecting from upper
GIT
 Formulation for colonic drug delivery are also suitable for delivery
of drug
 Therapeutic proteins ,enzymes, peptides are suitable for colonic
dug delivery e.g. Insulin , antibiotics.

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ADVANTAGES
 Smaller drug quantities.
 Reduces dosage frequency. lower cost of expensive drugs.
 Reduced incidence of side effects and drug interactions.
 Poorly absorbed drug molecules may have an improved
bioavailability.
 Reduce gastric irritation caused by many drugs
 Bypass initial first pass metabolism.
 Extended daytime or night-time activity.
 Improve patient compliance.
 Targeted drug delivery system.
 It has a longer retention time
 Less peptidase activity so peptides, oral vaccines, insulin,
growth hormones, can be given through this route
 Ideal side to cure local disaes

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DISADVANTAGES
 Multiple manufacturing steps.
 The metabolic degradation of the drug.
 Incomplete release of drug Bioavailability of drug may be low.
 Drug should be in solution form before absorption and there for
rate limiting step for poor soluble drugs.
 An important limitation of the pH sensitive coating technique have
uncertainty.
 Limitations of prodrug approach is that it is depends upon the
functional group available on the drug moiety for chemical linkage
 Lowering of bioavailability due to binding of drug to intestinal
content

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Anatomy and physiology of colon
 Structure of colon
 Colonic microflora
 Functions of colon
 Absorption of drug from colon
 Transit time
Colonic disease
 Inflammatory bowel disease
 Ulcerativ e colitis
 Crohns disease
 Colonic cancer
 Constipation
 Diarrhea
 Irritable bowel syndrom

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