7. ⢠Used in tissue engineering.
⢠Release their load on electrical stimuli.
⢠Traditionally, used nanocomposite hydrogels for
bioprinting-
⢠Carbon nanotube
⢠Graphene
⢠Gold-based
nanoparticles
6
8. Gold Nano rod infused gelatin methacryloyl (GelMA)
based bioink have been successfully developed.
Applications
⢠Regenerate and support cardiac
tissue
⢠Effectively coupling adjacent
cardiac tissues through its
electroconductivity.
7
9. 2. Photo-responsive functionality
⢠Nanoparticles have light to heat conversation capacity.
⢠On exposur to light heat is generated.
⢠Raised temperature gives antimicrobial activity.
(Applied in wound healing and wound dressing)
⢠Swelling and mechanical properties of nanocomposites can be
changed by altering exposure to the light.
8
Enhanced antimicrobial activity
11. ⢠Reversible thixotropic property increases injectability.
Share thinning
10
⢠Viscosity decreases as share stress is increases
12. Property of temperature dependent gelation can be
induced in the biomaterial with the help of nanoparticles.
11
13. References
⢠Shin SR, Bae H, Cha JM, Mun JY, Chen YC, Tekin H, Shin H, Farshchi S, Dokmeci MR, Tang
S, Khademhosseini A. Carbon nanotube reinforced hybrid microgels as scaffold
materials for cell encapsulation. ACS Nano 6 (1) : 362â372.
⢠He J, Shi M, Liang Y, Guo B. Conductive adhesive self-healing nanocomposite hydrogel
wound dressing for photothermal therapy of infected full-thickness skin wounds.
Chemical Engineering Journal. 2020 Aug 15;394:124888.
⢠Huang CT, Shrestha LK, Ariga K, Hsu SH. A grapheneâpolyurethane composite hydrogel
as a potential bioink for 3D bioprinting and differentiation of neural stem cells. Journal
of Materials Chemistry B. 2017;5(44):8854-64.
⢠Zhu K, Shin SR, van Kempen T, Li YC, Ponraj V, Nasajpour A, Mandla S, Hu N, Liu X,
Leijten J, Lin YD. Gold nanocomposite bioink for printing 3D cardiac constructs.
Advanced functional materials. 2017 Mar;27(12):1605352.
⢠Kim W, Jang CH, Kim GH. A myoblast-laden collagen bioink with fully aligned
Au nanowires for muscle-tissue regeneration. Nano letters. 2019 Oct
29;19(12):8612-20.
⢠Heo DN, Lee SJ, Timsina R, Qiu X, Castro NJ, Zhang LG. Development of 3D
printable conductive hydrogel with crystallized PEDOT: PSS for neural tissue
engineering. Materials Science and Engineering: C. 2019 Jun 1;99:582-90.
12
14. References
⢠Budharaju H, Subramanian A, Sethuraman S. Recent advancements in cardiovascular
bioprinting and bioprinted cardiac constructs. Biomaterials Science. 2021;9(6):1974-94.
⢠Shin SR, Jung SM, Zalabany M, Kim K, Zorlutuna P, Kim SB, Nikkhah M, Khabiry M, Azize
M, Kong J, Wan KT. Carbon-nanotube-embedded hydrogel sheets for engineering
cardiac constructs and bioactuators. ACS nano. 2013 Mar 26;7(3):2369-80.
⢠Navaei A, Saini H, Christenson W, Sullivan RT, Ros R, Nikkhah M. Gold nanorod-incorporated
gelatin-based conductive hydrogels for engineering cardiac tissue constructs. Acta biomaterialia.
2016 Sep 1;41:133-46.
⢠Shin SR, Farzad R, Tamayol A, Manoharan V, Mostafalu P, Zhang YS, Akbari M, Jung SM, Kim D,
Comotto M, Annabi N. Khademhosseini A A Bioactive Carbon Nanotube-Based Ink for Printing 2D
and 3D Flexible Electronics. Adv Mater. 2016;28:3280-9.
⢠Jain S, Singh SR, Pillai S. Toxicity issues related to biomedical applications of carbon nanotubes. J
Nanomed Nanotechol. 2012;3(140):2.
⢠Dumortier H. When carbon nanotubes encounter the immune system: desirable and undesirable
effects. Advanced drug delivery reviews. 2013 Dec 1;65(15):2120-6.
⢠Vardharajula S, Ali SZ, Tiwari PM, EroÄlu E, Vig K, Dennis VA, Singh SR. Functionalized carbon
nanotubes: biomedical applications. International journal of nanomedicine. 2012 Oct 9:5361-74.
13
15. References
⢠Motealleh A, De Marco R, Kehr NS. Stimuli-responsive local drug molecule delivery to
adhered cells in a 3D nanocomposite scaffold. Journal of Materials Chemistry B.
2019;7(23):3716-23.
⢠Fasciani C, Silvero MJ, Anghel MA, Arguello GA, Becerra MC, Scaiano JC. Aspartame-
stabilized goldâsilver bimetallic biocompatible nanostructures with plasmonic
photothermal properties, antibacterial activity, and long-term stability. Journal of the
American Chemical Society. 2014 Dec 17;136(50):17394-7.
⢠Lv SW, Liu Y, Xie M, Wang J, Yan XW, Li Z, Dong WG, Huang WH. Near-infrared light-
responsive hydrogel for specific recognition and photothermal site-release of
circulating tumor cells. ACS nano. 2016 Jun 28;10(6):6201-10.
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