Factor v leiden mutation

1. FACTOR V Leiden mutation
SURAMYA BABU

2.  Factor V Leiden is a genetic mutation ( gene mutation in coagulation
factor V ) that makes blood more prone to abnormal clotting.
 Individuals born with FVL are more likely to develop vein clots (deep vein
thrombosis (DVT) and pulmonary embolism (PE)

3. Deep vein thrombosis(DVT) AND pulmonary
embolism (PE)
 DVT : DVT is the blood clots which occur in deep veins such as leg veins (
Eg : jugular vein)
 PE : it occurs when clots break off from vein walls and travel through the
pulmonary arteries and reach the lungs .

4. APC ( Activate protein C )
 Activated protein C (APC) functions as a circulating anticoagulant which normally
helps prevent blood from clotting excessively.
 It works by inactivating the phospholipid bond between factor V and VIII and thus
breaking down the blood clot.

5. APCR (Activate protein C resistance )
 Activate protein C resistance means; due to mutation in coagulation
factor V , APC fails to inactivate factor V, which results in hypercoagulable
state which may leads to DVT and PE