This document discusses the use of herbal medicines for digestive system disorders. It details several herbs that can help relieve symptoms of irritable bowel syndrome, gastritis, ulcers, and other conditions. Chamomile, peppermint, fennel, anise, and ginger are highlighted for their antispasmodic and carminative properties in treating abdominal pain, cramps, and flatulence associated with IBS. The document cautions about potential herb-drug interactions and contraindications for certain herbs. It provides questions at the end to test the reader's understanding.
3. Digestive System Disorders
Gastritis
Stomach ulcers
Duodenal ulcers IBS
(Irritable Bowel Syndrome)
Crohn's disease
Gall bladder
disorders
Reference: Kerry Bone and Simon Mills (Auth.) - Principles and Practice of Phytotherapy. Modern Herbal Medicine (2013, Churchill Livingstone)
3
4. 4
IRRITABLE
B O W E L
SYNDROME
( I B S )
References: Francesco Capasso - Phytotherapy_ A Qu
Prof. Dr. med. Volker Schulz Rational Phytotherapy
4
15. Menthol
• Antispasmodic
• Carminative
. IBS
carminative with antispasmodic
activity
• occlusion of biliary ducts / gallstones
• inflammation of GIT / gall bladder
• impaired liver
Cytochrome P450 inhibitor
• Is: Omeprazole
• NSAIDs: Diclofenac, Coxibs
• Propranolol, Verapamil, Sartans
Peppermint
• Cholagogue
• Secretagogue
P
P
PP. Dyspepsia
15Francesco Capasso - Phytotherapy_ A Quick Reference to Herbal Medicine (2003, Springer) Thomas Fleming - PDR for Herbal Medicines (2000, Medical Economics Company)
WHO - WHO Monographs on Selected Medicinal Plants_ Volume 2 (Who Monographs on Selected Medicinal Plants) Zoë Gardner, Michael McGuffin - American Herbal Products Association's Botanical Safety Handbook
Prof. Dr. med. Volker Schulz, Prof. Dr. rer. nat. Rudolf Hänsel, Mark Blumenthal (auth.) - Rational Phytotherapy_ A Reference Guide for Physicians and Pharmacists
16. Apigenin
Bisabolol
Chamazulene
chamomile
• Antispasmodic
• Carminative
• ↓ Proteolytic
activity of Pepsin
A
B
C
c
≈ ESTROGEN
• Contraceptive pills
• Tamoxifen
Allergy
16
Inflammatory GIT diseases
associated with SPAMS
Alcohol
Benzodiazepines
Coumarin anticoagulants
A
B
C Bleeding
Prof. Dr. med. Volker Schulz, Prof. Dr. rer. nat. Rudolf Hänsel, Mark Blumenthal (auth.) - Rational Phytotherapy_ A Reference Guide for Physicians and Pharmacists
Thomas Fleming - PDR for Herbal Medicines (2000, Medical Economics Company)
Zoë Gardner, Michael McGuffin - American Herbal Products Association's Botanical Safety Handbook (2013, CRC Press)
17. Trans-anethole
. Dyspepsia
Fennel
• Antispasmodic
• Carminative
. IBS
carminative with antispasmodic
activity
Cross sensitivity
↓ Blood Clotting
X Carrots Allergic Patients
X Bleeding disorders
≈ ESTROGEN
• Contraceptive pills
• Tamoxifen
F
17Thomas Fleming - PDR for Herbal Medicines (2000, Medical Economics Company)
Zoë Gardner, Michael McGuffin - American Herbal Products Association's Botanical Safety Handbook (2013, CRC Press)
18. A llergy
Trans-Anethole
Anise
≈ ESTROGEN
• Contraceptive pills
• Tamoxifen
. Dyspepsia
. IBS
carminative with antispasmodic
activity
• Antispasmodic
• Carminative
• Expectorant
A
18
A
A
Prof. Dr. med. Volker Schulz, Prof. Dr. rer. nat. Rudolf Hänsel, Mark Blumenthal (auth.) - Rational Phytotherapy_ A Reference Guide for Physicians and Pharmacists (2004, Springer)
World Health Organization - Who Monographs on Selected Medicinal Plants Volume 3 (2007, World Health Organization)
Thomas Fleming - PDR for Herbal Medicines (2000, Medical Economics Company)
19. • Anti-emetic
•↑Peristalsis & Tone
inger
Anticoagulants / Antiplatelet
e.g. Warfarin
Gingerols
19
. Dyspepsia
. Loss of appetite
G
Thomas Fleming - PDR for Herbal Medicines (2000, Medical Economics Company)
Zoë Gardner, Michael McGuffin - American Herbal Products Association's Botanical Safety Handbook (2013, CRC Press)
Ghayur, M. N. and Gilani, A. H. Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig.Dis.Sci 2005;50
due to antithrombotic effect
. allstones
. Morning sickness in pregnancy
“Permitted Safe dose in Pregnancy
. Risk of Hemorrhage
“Permitted Safe dose in Pregnancy: 2gm”
“Permitted Safe dose: ≤ 6gm”
G
20. • Apigenin
• Luteolin
GIT disorders of
NERVOUS
origin
Pa ss ion flower
20
edative effect
C-glycosyl-flavones:
Thomas Fleming - PDR for Herbal Medicines (2000, Medical Economics Company)
Zoë Gardner, Michael McGuffin - American Herbal Products Association's Botanical Safety Handbook (2013, CRC Press)
edatives (CNS Depressants)
↑ leepiness
SS
S
S
S
For
NERVOUS
restlessness
Stimulate Uterine
Contractions
X Pregnancy
21. is available on the safety of most
herbs during pregnancy & lactation.
Although no concerns identified, safety has not been
conclusively established.
Preparations containing these herbs are better avoided.
Special considerations for the use of preparations
containing ( Ginger & Passion flower ) – Mentoplex,
as both are contraindicated during pregnancy.
21
26. Question 1:
Mention 1 herbal constituent of
After Meals clarifying the indication
for its use.
26
27. Answer:
27
( Peppermint / Chamomile / Fennel )
Indicated for their Antispasmodic
and Carminative effects for relief of
IBS / Flatulence / Dyspepsia.
28. Question 2:
The concomitant use of the 3 discussed
digestive herbal preparations is not
recommended with certain medications
due to Chamomile content.
28
Mention 1 possible Herb-Drug interaction
