This document summarizes the medical history and treatment of a 19-year-old female patient living with HIV. She was started on multiple ART regimens as a child, including Stocrin, Varidex, and Zerit, and later Triomune 30, which failed. She developed side effects including pancreatitis after being switched to a second line regimen including Kaletra. Multiple switches were required due to toxicity and resistance issues. Over time her health stabilized on a regimen including TDF, AZT, and Aluvia, though adherence was poor. Managing pediatric HIV treatment long-term in resource-limited settings presents many challenges.