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A CASE OF ACUTE GASTROENTERITIS WITH
PERIPHERAL CIRCULATORY FAILURE AND
ACUTE KIDNEY INJURY REQURING RENAL
REPLACEMENT THERAPY.
Dr. Suraj Adhikari(PG Medicine)
Dr. Parvati Nandy(Professor and HOD Medicine)
A 68 years old male ,Mr X a known diabetic and
hypertensive under medication from Kannur disctrict
in Kerala reached Gangtok via Chennai and Kolkata in
the evening of 25th of February where he had dinner in
a local hotel where he was lodging. After three to four
hours he developed sudden onset abdominal cramps
followed by multiple episodes of watery stool, for
which he attended the ER of CRH.
Watery stool was associated with nausea but no
vomiting.There was no history of fever, pain
abdomen,antibiotic use,tenesmus,no blood in stool,No
history of similar complaints from fellow travellers.
He was having 2-3 loose stool every 10 minutes.
His urine output decreased over the next few hours
and he gradually became drowsy overnight . His urine
output ,blood pressure and consciousness level was
strictly monitored hourly along with appropriate
medications and required investigations.In less than 5
hours he developed acute renal failure with severe
metabolic acidosis and shock.With timely
interventions with inotropes and 3 cycles of
hemodialysis over the next two days he regained
normalcy and we could dicharge him on the sixth day
of his admission.
DIFFERENTIAL DIAGNOSIS:
1)Bacterial food poisoning
Staphylococcus aureus Intense vomiting and watery diarrhoea 1-4
hours after ingestion
Bacillus cereus Vomiting after 1-6 hours and diarrhoea after
8-16 hours of ingestion
Clostridium perfringens Acute onset of abdominal cramps with
diarrhoea after 8-24 hours of ingestion.
Vomiting is rare
Vibrio Cholera Profuse non-bloody diarrhoea 8-24 hours
after ingestion, rice watery stool,vomiting
may be present.
Clostridium botulinum Descending weakness and paralysis starts 1-4
days after ingestion followed by constipation
Salmonella Abrupt onset of diarrhoea,low grade
feverabdominal pain ,vomiting 6-48 hours
after ingestion
2)Traveller’s diarrhoea
Enterotoxigenic E.coli Acute onset watery diarrhoea 24-48
hours after ingestion,vomiting and
abdominal cramps may be present
Enteroaggregative E.coli Can cause bloody diarrhoea
Campylobacter jejuni Foul smelling watery diarrhoea followed
by bloody diarrhoea
Shigella Abrupt onset of bloody diarrhoea,cramps
tenesmus and fever 12-30 hours after
ingestion
Giardia Lambia Mild diarrhoea with nausea and abdominal
cramps 2-3 days aftyer ingestion
Enatamoeba histolytica Bloody diarrhoea,complicated by liver
abscess
Rotavirus Common with children,watery bloodless
diarrhoea,vomiting,low grade
fever,abdominal cramps
EXAMINATION FINDINGS:
BP 138|62 MMHG
PR 86 BPM, weak with low volume.
RR 20/min,Abdomino-thoracic.
Temperature 99 degrees Farenhiet.
SP02 90 % in RA
CNS GCS-E4V5M6
CVS S1S2 were heard,no murmur
P/A Soft, bowel sounds increased
RS B/L AE present , normal vesicular breath
sounds , fine basal crepitations
SIGNS OF DEHYDRATION:
Sunken eyes
Parched lips
Hollow temporal fossa
Tongue dry and coated
Lax subcutaneous tissue
Loss of skin elasticity
Pinched up nose
DAY WISE MONITORING CHART:
25/2/22 26/2/22 27/2/22 28/2/22 1/2/22
Urine
output
800ml 100ml 500ml 1800ml 1650ml
Stool 10 14 5 5 2
Blood
pressure
110/60 80/60 120/60 130/80 130/80
Urea 33 88.7 78.5 70.5 67.6
Creatini
ne
0.63 4.17 3.66 2.86 1.60
Sodium 142.2 136 139 144 138
Potassiu
m
2.68 2.86 4.05 3.82 3.56
INVESTIGATION FINDINGS:
Sodium 133 TLC 29
Potassium 4.21 HGB 13
Calcium 12.5 HCT
Urea 29 PLT 325
Creatinine 1.51 N 92.2%
CRP 8.3 FBS 178
TB 0.48 PPBS 223
AST 34 HBA1C 7%
ALT 34 Urine glucose 4+
INR 1.16 Urine protein 3+
Amylase 69 Lipase 41
USG W/A Coarsened hepatic echotexture with
mild irregular margins s/o
CLD,thickened UB
wall,prostatomegaly
Stool RE No ova,no cyst,no amoeba,darting
motility absent by hanging drop method
Stool C/S sterile
Blood C/S Serratia Liquefaciens group.
Urine C/S sterile
Widal Nonsignificant titre
Weil felix OXK-80
DIAGNOSIS:
Type 2 Diabetes Mellitus
Hypertension
Acute Gastroenteritis
Hypovolemic Shock
Severe Metabolic Acidosis
Sepsis (Serratia Liquefaciens)
Acute Kidney Injury
TREATMENT GIVEN:
Oxygen inhalation 3-4L/min
Antibiotics Meropenam , Metrogyl
,Ciprofloxacin
Fluids Intravenous NS,RL;ORS
solution
Anti-diarroheal Racecadotril, Loperamide
Anti-diabetic Basal and bolus insulin
Vasopressors Infusion Noradrenaline
Probiotics
Proton pump inhibitors Pantoprazole
Hemodialysis, line
placement in the right
femoral vein
Renal replacement therapy Three cycles of Hemodialysis

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A case of AGE with peripheral circulatory failure.pptx

  • 1. A CASE OF ACUTE GASTROENTERITIS WITH PERIPHERAL CIRCULATORY FAILURE AND ACUTE KIDNEY INJURY REQURING RENAL REPLACEMENT THERAPY. Dr. Suraj Adhikari(PG Medicine) Dr. Parvati Nandy(Professor and HOD Medicine)
  • 2. A 68 years old male ,Mr X a known diabetic and hypertensive under medication from Kannur disctrict in Kerala reached Gangtok via Chennai and Kolkata in the evening of 25th of February where he had dinner in a local hotel where he was lodging. After three to four hours he developed sudden onset abdominal cramps followed by multiple episodes of watery stool, for which he attended the ER of CRH. Watery stool was associated with nausea but no vomiting.There was no history of fever, pain abdomen,antibiotic use,tenesmus,no blood in stool,No history of similar complaints from fellow travellers. He was having 2-3 loose stool every 10 minutes.
  • 3. His urine output decreased over the next few hours and he gradually became drowsy overnight . His urine output ,blood pressure and consciousness level was strictly monitored hourly along with appropriate medications and required investigations.In less than 5 hours he developed acute renal failure with severe metabolic acidosis and shock.With timely interventions with inotropes and 3 cycles of hemodialysis over the next two days he regained normalcy and we could dicharge him on the sixth day of his admission.
  • 4. DIFFERENTIAL DIAGNOSIS: 1)Bacterial food poisoning Staphylococcus aureus Intense vomiting and watery diarrhoea 1-4 hours after ingestion Bacillus cereus Vomiting after 1-6 hours and diarrhoea after 8-16 hours of ingestion Clostridium perfringens Acute onset of abdominal cramps with diarrhoea after 8-24 hours of ingestion. Vomiting is rare Vibrio Cholera Profuse non-bloody diarrhoea 8-24 hours after ingestion, rice watery stool,vomiting may be present. Clostridium botulinum Descending weakness and paralysis starts 1-4 days after ingestion followed by constipation Salmonella Abrupt onset of diarrhoea,low grade feverabdominal pain ,vomiting 6-48 hours after ingestion
  • 5. 2)Traveller’s diarrhoea Enterotoxigenic E.coli Acute onset watery diarrhoea 24-48 hours after ingestion,vomiting and abdominal cramps may be present Enteroaggregative E.coli Can cause bloody diarrhoea Campylobacter jejuni Foul smelling watery diarrhoea followed by bloody diarrhoea Shigella Abrupt onset of bloody diarrhoea,cramps tenesmus and fever 12-30 hours after ingestion Giardia Lambia Mild diarrhoea with nausea and abdominal cramps 2-3 days aftyer ingestion Enatamoeba histolytica Bloody diarrhoea,complicated by liver abscess Rotavirus Common with children,watery bloodless diarrhoea,vomiting,low grade fever,abdominal cramps
  • 6. EXAMINATION FINDINGS: BP 138|62 MMHG PR 86 BPM, weak with low volume. RR 20/min,Abdomino-thoracic. Temperature 99 degrees Farenhiet. SP02 90 % in RA CNS GCS-E4V5M6 CVS S1S2 were heard,no murmur P/A Soft, bowel sounds increased RS B/L AE present , normal vesicular breath sounds , fine basal crepitations
  • 7. SIGNS OF DEHYDRATION: Sunken eyes Parched lips Hollow temporal fossa Tongue dry and coated Lax subcutaneous tissue Loss of skin elasticity Pinched up nose
  • 8. DAY WISE MONITORING CHART: 25/2/22 26/2/22 27/2/22 28/2/22 1/2/22 Urine output 800ml 100ml 500ml 1800ml 1650ml Stool 10 14 5 5 2 Blood pressure 110/60 80/60 120/60 130/80 130/80 Urea 33 88.7 78.5 70.5 67.6 Creatini ne 0.63 4.17 3.66 2.86 1.60 Sodium 142.2 136 139 144 138 Potassiu m 2.68 2.86 4.05 3.82 3.56
  • 9. INVESTIGATION FINDINGS: Sodium 133 TLC 29 Potassium 4.21 HGB 13 Calcium 12.5 HCT Urea 29 PLT 325 Creatinine 1.51 N 92.2% CRP 8.3 FBS 178 TB 0.48 PPBS 223 AST 34 HBA1C 7% ALT 34 Urine glucose 4+ INR 1.16 Urine protein 3+ Amylase 69 Lipase 41
  • 10. USG W/A Coarsened hepatic echotexture with mild irregular margins s/o CLD,thickened UB wall,prostatomegaly Stool RE No ova,no cyst,no amoeba,darting motility absent by hanging drop method Stool C/S sterile Blood C/S Serratia Liquefaciens group. Urine C/S sterile Widal Nonsignificant titre Weil felix OXK-80
  • 11.
  • 12. DIAGNOSIS: Type 2 Diabetes Mellitus Hypertension Acute Gastroenteritis Hypovolemic Shock Severe Metabolic Acidosis Sepsis (Serratia Liquefaciens) Acute Kidney Injury
  • 13. TREATMENT GIVEN: Oxygen inhalation 3-4L/min Antibiotics Meropenam , Metrogyl ,Ciprofloxacin Fluids Intravenous NS,RL;ORS solution Anti-diarroheal Racecadotril, Loperamide Anti-diabetic Basal and bolus insulin Vasopressors Infusion Noradrenaline Probiotics Proton pump inhibitors Pantoprazole Hemodialysis, line placement in the right femoral vein Renal replacement therapy Three cycles of Hemodialysis