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Using Artificial Intelligence
in the field of Diagnostics
2,500,000,000
Gigabytes of data produced daily
2
80%
Percent of World’s Population in low-income communities.
3
▫ Large amount of data perfect for AI
▫ Room for improvement
▫ Millions of lives affected by improvements in this field
AI IN DIAGNOSTICS
4
What is a Neural Network?
5
AI for Diabetic Retinopathy
Eyeagnosis Teammates:
• Neeyanth Kopparapu
• Kavya Kopparapu
• Justin Zhang
332,000,000
Diabetic patients in middle-low income communities
7
> 50%
Estimated cases of diabetes still undiagnosed
8
9
Diagnosis for Diabetic Retinopathy needs to be:
- Inexpensive
- Quick
- Accessible
- (finally) Accurate
PROBLEM
10
11
Efficient
• Subjectivity
• Requires >2 hours/patient
• Ophthalmologist : Patient >
1:1000
USING ARTIFICIAL INTELLIGENCE
Inexpensive
• Current diagnostic tools are
expensive
• Pathologist required to
diagnose
12
▫ Accessibility  use a common devices
▫ Inexpensive  don’t use expensive equipment
▫ Quick  AI models are very quick
▫ Diabetic Retinopathy  common procedures include dilated eye
exam, fluorescein angiography, optical tomography
DRAFTING A SOLUTION
13
SOLUTION
14
NEXT STEPS
Assemble Dataset
NIH eyeGENE Dataset
of retinal images
Train Model
ResNet-50
Convolutional Neural
Network
Create Supporting
Technology
- Mobile Application
- Lens Holder
15
What is a Convolutional Neural Network?
16
DATASET
17
MODEL ARCHITECTURE
18
MODEL RESULTS
19
20
SUPPORTING TECHNOLOGY
- Mobile Application
- Facilitate Transfer of Image
- Preprocess Image
- Lens System
- Holds multiple lenses
- Better picture of the Retina
MOBILE APPLICATION
21
LENS SYSTEM
22
Can We Do Better?
24
HOW CAN WE IMPROVE?
- Accessibility
- Accuracy
- Trust
MOBILE APPLICATION
25
IMPROVING TRUST
26
AI for Major Depressive Disorder
TweePression teammates:
• Neeyanth Kopparapu
• Kaien Yang
41.6%
Percent of Students with Depression
28
43%
Percent of Students with Depression that seek help
29
Accurate
• Current depression screening
methods have accuracies
under 75%
A DIFFERENT PROBLEM
Non-Intrusive
• Over 40% of adults keep
depression symptoms to
themselves
• Opening up to doctors is
harder than online (Social
Media)
30
DRAFTING A SOLUTION
▫ Accuracy  Bigger collection of data, more viewpoints
▫ Non-Intrusive  Social Media?
31
USING ARTIFICIAL INTELLIGENCE
Sentiment Analysis
From individual social media
posts, calculate sentiment of
user
Depression Prognosis
From Sentiment Analysis, give
final prediction about user.
32
33
INITIAL APPROACH
▫ Classify each word individually
▫ Combine classifications for final output
RESULTS
34
True Positive
104,460
True Negative
121,065
False Negative
11,242
(Type II Error)
False Positive
13,233
(Type I Error)
Condition Positive Condition Negative
Test
Positive
Test
Negative
Can We Do Better?
• The main goal of using AI is to increase accuracy
• Using as much data as possible is beneficial
• Accessibility isn’t the immediate problem
• Using medical machines to increase data output
REANALYZING THE PROBLEM
36
BAG OF WORDS
▫ “How could I hate you?”
▫ “He said he loved ONLY me”
vs “He said ONLY he loved
me”
37
How
Could
I
You?
Hate
NEW MODEL
38
2:
CONVOLUTIONAL
LAYER
Sentiment
Analysis
Dataset
Kaggle Movie
Reviews
Dataset
Google
Word2Vec
DENSE NEURAL NETWORK
1:
EMBEDDING
LAYER
3:
MAX
POOLING
2D
LAYER
OUTPUT:
SOFTMAX
ACTIVATION
5:
DENSE
LAYER
4:
DENSE
LAYER
RESULTS
39
True Positive
240,303
True Negative
184,257
False Negative
9,702
(Type II Error)
False Positive
15,738
(Type I Error)
Condition Positive Condition Negative
Test
Positive
Test
Negative
FMRI ANALYSIS MODEL
40
Convolution + ReLU Max pooling Fully Connected + ReLU Softmax
Image Input:
fMRI Scans
Classification
Output:
MDD Prediction
FMRI RESULTS
41
True Positive
446
True Negative
372
False Negative
29
(Type II Error)
False Positive
28
(Type I Error)
Condition Positive Condition Negative
Test
Positive
Test
Negative
SUPPORTING TECHNOLOGY
▫ Server to process queries
- Validation of Social
Media, Runs AI Model,
Outputs Result
▫ Website for user interface
with access to social media
pages
42
SERVER
43
MRI
Upload
Healthy
MDD
Input
Twitter
Username
no
yes
no
yes
no
yes
Depression
Free?
Valid
User
Name?
> 100
Tweets?
MDD
Healthy
Insufficient
Tweets
Invalid
Username
Looking Forward
AI IN DIAGNOSTICS
▫ Will it Replace Doctors?
- Loss of Jobs?
▫ How can we justify outputs?
- Trust among patients?
▫ How can we scale this?
▫ What should be prioritized?
▫ What happens if the AI is
wrong?
45
46
CURRENT PROBLEMS IN AI
▫ Biased datasets
▫ Unethical training procedures
▫ Inaccessibility to data
47
FINAL THOUGHTS
▫ Diagnostics is the perfect field for AI
▫ However, there is change that must come before
Explanations
▫ Adaption toward specific communities

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Using Artificial Intelligence in the field of Diagnostics_Case Studies.ppt

Editor's Notes

  1. Say the Statistic, then say “5 years ago our current state of technology could not keep up… this is really where artificial intelligence began to rise”
  2. Stay statistic… “More specifically, AI has started to rise in the field of medicine and healthcare because there are many people that can’t access the expensive healthcare systems in many countries today”
  3. “AI has a lot of potential in diagnostics since the modern data revolution… each medical device from MRI scanners to Glucose Meters record data to send to a doctor or to store for a patient. AI can capitalize on this information to form predictions.
  4. “In general, NN’s in the most basic sense are just layers of neurons that are connected with neurons in other layers. To send information through the neuron, the signal is passed through a neuron, send through a nonlinear function, and if the final number exceeds a threshold, it fires to all of its connections, until it reaches the output layer, whose information is passed to the user… Backpropogation involves adjusting weights to fit information that was passed better. Talk about what happens for the rest of the presentation.
  5. First application I worked on was using AI for Diabetic Retinopathy
  6. Explain what Diabetic Retinopathy is a complication of diabetes that affects the eye, caused by damage to blood vessels, and poorly controlled blood sugar.
  7. DR Is RIGHT?? LOOKS IDENTICAL!
  8. Dialiated Eye Exam  Eyedrops and then Retinal Image Fluorescein Angiography  Using injected dye to pinpoint broken & closed blood vessels. Optical tomography  shows thickness of retina.