Selye defined stress as the non-specific response of the body to any demand placed upon it. Holmes and Rahe studied the relationship between life changes and illness, developing a scale to measure major life changes and finding that greater life changes correlated with increased likelihood of illness. Lazarus's theory emphasized that cognitive appraisal determines what is stressful and how it is coped with, and that emotions result from stress responses rather than cause them. Coping can shape and respond to demands to influence future experiences.