Information slides on Vapocoolant for Pre-Injection Anesthesia.

1. Vapocoolants for pre-injectionVapocoolants for pre-injection
anesthesiaanesthesia

2. What is a vapocoolant?What is a vapocoolant?
 non-pharmaceutical topicalnon-pharmaceutical topical
anestheticanesthetic
 extremely effective at anesthetizingextremely effective at anesthetizing
target areas to give very rapid, lowtarget areas to give very rapid, low
cost, pain management for a largecost, pain management for a large
variety of proceduresvariety of procedures
 intended for topical application tointended for topical application to
skin, intact mucous membranes (oralskin, intact mucous membranes (oral
cavity, nasal passageways and thecavity, nasal passageways and the
lips)lips)

3. How does a vapocoolant work?How does a vapocoolant work?
 Vapocoolants are liquefied gases. WhenVapocoolants are liquefied gases. When
vapocoolants are compressed orvapocoolants are compressed or
contained, such as in a can, they are in acontained, such as in a can, they are in a
liquid form however when sprayed into aliquid form however when sprayed into a
warm atmosphere or onto warm skin awarm atmosphere or onto warm skin a
phase change occurs to the vapor state.phase change occurs to the vapor state.
When contacting the skin, this phaseWhen contacting the skin, this phase
change causes an endothermic or coolingchange causes an endothermic or cooling
reaction to occur which refrigerates thereaction to occur which refrigerates the
point of evaporation from the skin.point of evaporation from the skin.

4. Historical - VapocoolantsHistorical - Vapocoolants
 Gebauer’s Ethyl ChlorideGebauer’s Ethyl Chloride®® has beenhas been
made and sold by Gebauer Companymade and sold by Gebauer Company
for over 100 years.for over 100 years.
 New generation HFC based, non-New generation HFC based, non-
ozone depleting, non-flammableozone depleting, non-flammable
compounds have been recently FDA-compounds have been recently FDA-
approved for pre-injection anesthesiaapproved for pre-injection anesthesia

5. Benefits of vapocoolantsBenefits of vapocoolants
 Ease of application (aerosol spray)Ease of application (aerosol spray)
 Immediate results (anesthetic effectImmediate results (anesthetic effect
within seconds)within seconds)
 Reduced patient anxietyReduced patient anxiety
 Increased patient throughputIncreased patient throughput
 Cost pennies per applicationCost pennies per application
 510(k) cleared product – FDA510(k) cleared product – FDA
approvedapproved

6. Vapocoolants- what are the risks?Vapocoolants- what are the risks?
 Over-application may alter skinOver-application may alter skin
pigmentation?pigmentation?
 Overspray in peri-orbital regionOverspray in peri-orbital region
 Cost?Cost?
 ??????

7. Current vapocoolant studyCurrent vapocoolant study
 Efficacy and Safety Study OfEfficacy and Safety Study Of
Vapocoolant Spray As AnVapocoolant Spray As An
Anesthetic Prior ToAnesthetic Prior To
Transcutaneous Botulinum ToxinTranscutaneous Botulinum Toxin
(Botox(Botox®®) Injections) Injections

8. Vapocoolant comfort shieldVapocoolant comfort shield

9. ResultsResults
 Preliminary results show a very highPreliminary results show a very high
degree of patient acceptancedegree of patient acceptance
 Very often no pain at allVery often no pain at all
 No hyperpigmentationNo hyperpigmentation
 Works extremely well for treatmentWorks extremely well for treatment
of axillary hyperhidrosisof axillary hyperhidrosis

10. ResultsResults
 Preliminary results show a very highPreliminary results show a very high
degree of patient acceptancedegree of patient acceptance
 Very often no pain at allVery often no pain at all
 No hyperpigmentationNo hyperpigmentation
 Works extremely well for treatmentWorks extremely well for treatment
of axillary hyperhidrosisof axillary hyperhidrosis