This document provides an overview of Revathi Mohan's Masters thesis topic on drug addiction. It includes sections that discuss the reasons for and effects of drug addiction, comorbidity of addiction and mental health disorders, challenges with addiction treatment and recovery, specifics on various drugs (opioids, sedatives, stimulants, etc.), and the role of organizations in addressing addiction. Graphs and diagrams are presented on topics like why addiction is difficult to quit, the dual epidemics of drug use and HIV/AIDS, and opportunities for international drug research collaboration.
6. COMORBIDITY
Drug Users have a Higher Risk of
Developing Mental Disorders
•Psychosis
•Depression
•Anxiety
•Panic attacks
Example: SMOKING EPIDEMIOLOGY
normal population:
23%
alcoholism:
90%+
other addictions:
90%+
schizophrenia:
85%
depression:
80%
7. Why Can’t Addicts Just Quit?
Non-Addicted Brain
Addicted Brain
Control
Control
Saliency
Drive
NO
GO
Saliency
Memory
Source: Adapted from Volkow et al., Neuropharmacology, 2004.
Drive GO
Memory
Because Addiction Changes Brain Circuits
8. We Need to Treat the
Whole
Person!
Pharmacological
(medications)
Medical and
In Social
Behavioral Therapies
Social Services
Context
39. Fund international research
Provide training and exchange opportunities
Set international research priorities
Organize & sponsor conferences and meetings
Binational agreements
Dissemination of information
40. I.
Drug abuse is a global
phenomenon
5 percent of people aged 15-64
15.9
13.7
7.9
Millions of Users
Cannabis
Amphetamines
Ecstasy
Cocaine
Opiates
26.2
II. Intertwined dual-epidemics of
drug addiction & HIV/AIDS
160.9
UNODC 2005 World Drug Report
HIV Infections Attributed to
Injection Drug Use and Risky
Sexual Behaviors Related to
Drug Abuse
III. Take advantage of unique opportunities to advance scientific
knowledge through research
Editor's Notes
Comorbid mental illness is common among substance abusers, including smokers, with much higher rates than in the normal population. Co-occurrence of other drug addictions is also much higher. Drug users also have a higher risk of developing mental disorders, although the order of these events can be difficult to determine precisely.
Addiction changes brain circuitry, making it hard to “apply the brakes” to detrimental behaviors. In the non-addicted brain, control mechanisms constantly assess the value of stimuli and the appropriateness of the planned response, applying inhibitory control as needed. In the addicted brain, this control circuit becomes impaired through drug abuse, losing much of its inhibitory power over the circuits that drive response to stimuli deemed salient.
Addiction requires treatment that addresses its complexity. Substance abuse treatment should address the whole person and can include medications, behavioral therapies, and ancillary support services.
Swiss chemist “Albert hoffman”
NIDA’s international program makes significant contributions to drug abuse research. These include funding and training, priority setting, conference sponsorship, and information dissemination.
Drug abuse is a global problem. An international focus allows the sharing of important findings with a wider audience, particularly benefiting those countries where HIV/AIDS is prevalent. It also allows researchers to take advantage of the unique cultural, biological, and environmental factors that exist in different regions of the world, which can reveal important and novel information about our shared health concerns regarding drug abuse and HIV.