The ability of micelles to increase the solubility of materials that are normally insoluble in the dispersion medium.

2. The ability of micelles to increase the solubility of materials that areThe ability of micelles to increase the solubility of materials that are
normally insoluble in the dispersion medium.normally insoluble in the dispersion medium.
SSOLUBILIZATIONOLUBILIZATION
Methods Of Solubilization
1.1. CCOMPLEXATIONOMPLEXATION
2.2. HHYDROTROPICYDROTROPIC SSOLUBILIZATIONOLUBILIZATION
3.3. MMICELLERICELLER SSOLUBILIZATIONOLUBILIZATION
4.4. FFAST DISSOLVING PRODUCTSAST DISSOLVING PRODUCTS
5.5. SOLID DISPERSIONSOLID DISPERSION

3. CCLATHERATESLATHERATES
The individual host molecules link together to form aThe individual host molecules link together to form a
cage– or a cup–shaped structure, the open end of whichcage– or a cup–shaped structure, the open end of which
joins with the open end of a second similar structure tojoins with the open end of a second similar structure to
form the cage, An inclusion compound is a unique form ofform the cage, An inclusion compound is a unique form of
chemical complex in which one molecule is enclosedchemical complex in which one molecule is enclosed
within another molecule or structure of molecules.within another molecule or structure of molecules.

4. HHYDROTROPICYDROTROPIC SOLUBILITYSOLUBILITY
Increase in saturation solubility of a substance in water byncrease in saturation solubility of a substance in water by
the addition of organic salts or also non-electrolytesthe addition of organic salts or also non-electrolytes
UUpto 50% nicotianamide with a triple increase in thepto 50% nicotianamide with a triple increase in the
saturation solubility)saturation solubility)

5. MMICELLERICELLER SSOLUBILIZATIONOLUBILIZATION
The spontaneous passage of solute molecules of a substance insoluble
in water into an aqueous solution of a surfactant in which a
thermodynamically stable solution is formed.

6. FFAST DISSOLVING PRODUCTSAST DISSOLVING PRODUCTS
AA dosage form for oral administration, which when placed in thedosage form for oral administration, which when placed in the
mouth disintegrates rapidly or dissolves and can be swallowed in themouth disintegrates rapidly or dissolves and can be swallowed in the
form of liquidform of liquid..

7. SOLID DISPERSION
A dispersion of one or more ingredients in an inert carrier, in solid
state prepared by the melting method

8. AApplicationpplication OOff SSolubilizationolubilization
1. In Pharmaceuticals.
2. In Textile processing.
3. In Analytical chemistry & detergency.
4. In Cosmetics.
5. In Environmental & agricultural processes.
MMechanismechanism
Two major mechanisms of solubilization process of oil by surfactantTwo major mechanisms of solubilization process of oil by surfactant
micelles, affecting the kinetics of solubilizationmicelles, affecting the kinetics of solubilization::
1.1.Surface reaction, i.e.,Surface reaction, i.e., by transient adsorption of micelles at theby transient adsorption of micelles at the
water-oil interfacewater-oil interface, and, and
2.2.Bulk reaction,Bulk reaction, whereby the surfactant micelles capture dissolvedwhereby the surfactant micelles capture dissolved
oil molecules.oil molecules.

9. CConclusiononclusion
In this modern era solubilization process isIn this modern era solubilization process is
tremendously used mainly in our pharmaceuticaltremendously used mainly in our pharmaceutical
field to create a liquid medicament with a goodfield to create a liquid medicament with a good
solubility & a better bioavailability, even though it issolubility & a better bioavailability, even though it is
used in analytical chemistry, cosmetic preparations,used in analytical chemistry, cosmetic preparations,
in textile industry, preparation of detergents, etc.in textile industry, preparation of detergents, etc.
there are further researches carry onthere are further researches carry on
pharmaceutical & analytical field for betterment ofpharmaceutical & analytical field for betterment of

10. RREFERENCESEFERENCES
1. B1. Brahmankarrahmankar D.M, JD.M, Jaiswalaiswal S.B “S.B “Biopharmaceutics & pharmacokinetics aBiopharmaceutics & pharmacokinetics a
treatisetreatise” p” publishedublished byby Vallabh prakashanVallabh prakashan 2009, page no.348-357.2009, page no.348-357.
2. A2. Aultonulton M.E “M.E “The science of dosage form designThe science of dosage form design”, 2nd edition, published”, 2nd edition, published
byby ChurchillLivingstoneChurchillLivingstone,2002, page no.113–138 & 234–252.,2002, page no.113–138 & 234–252.
3. G3. Gennaroennaro A.R.RA.R.Remingtonemington ““The science and practice of pharmacyThe science and practice of pharmacy” 21” 21stst
edition, published byedition, published by Lippincott, Williams &Wilkins,Lippincott, Williams &Wilkins, 2005,page no.867-868.2005,page no.867-868.
4. M4. Martinartin A “A “Physical PharmacyPhysical Pharmacy”, 4”, 4thth
edition. Published by,edition. Published by, A. WaltersA. Walters
Kluwer Co,PhiladelphiaKluwer Co,Philadelphia Publication,pvt.Ltd.2003, page no.-212-250.Publication,pvt.Ltd.2003, page no.-212-250.
5. “I5. “Indianndian PPharmacopoeiaharmacopoeia 2007” published2007” published by The Indian Pharmacopoeiaby The Indian Pharmacopoeia
Commision Central Indian Pharmacopoeia Laboratory Govt. of India,Commision Central Indian Pharmacopoeia Laboratory Govt. of India,
Ministry of Health & Family Welfare,Ministry of Health & Family Welfare,Ghaziabad,page no. 1082-1088.Ghaziabad,page no. 1082-1088.
6. S6. Swarbrickwarbrick J ”J ”Encyclopedia of Pharmaceutical TechnologyEncyclopedia of Pharmaceutical Technology” (Vol- I) 3” (Vol- I) 3rdrd
edition, published byedition, published by Informa HealthcareInforma Healthcare, page no.1082, 1104 & 1183., page no.1082, 1104 & 1183.
7. J7. Journal of Advanced Pharmacy Education & Researchournal of Advanced Pharmacy Education & Research (2012) ISSN 2249-(2012) ISSN 2249-
3379 Page no. 32-67.3379 Page no. 32-67.

11. Thank YouThank You