Dental stem cells


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Dental stem cells and regenerative dentistry

Dental stem cells

  1. 1. B Y : R A G A A H M E D B U Z G H A I AI N T E R N , U N I V E R S I T Y O F B E N G H A Z I -F A C U L T Y O F M E D I C I N E – D E N T A LD E P A R T M E N TL I B Y ADental stem cells : an overviewof future dentistry6/23/20131by Raga buzghaia
  2. 2.  The recent discovery of dental stem cells in 2000 bya researcher at the National Institutes of Health –USA , has developed a wide range of possiblities inthe regeneration of the different tissues and organs . Researches have been carried out the past yearsevolving a new branch in dentistry known as “regenerative dentistry “6/23/20132by Raga buzghaia
  3. 3. Introduction Stem cells are immature, unspecialized cells in thebody that are able to grow into specialized cell typesby a process known as “differentiation.” There are two primary sources of stem cells:embryonic stem cells and adult stem cells. Adult stem cells are found in many tissuesincluding dental pulp .6/23/20133by Raga buzghaia
  4. 4.  It is now known that adult stem cells taken from onearea of the body can be transplanted into anotherarea and grown into a completely different type oftissue. Dental stem cells are being studied for a wide rangeof diseases due to their ability to form connective, neural , muscle , bone and dental tissues .6/23/20134by Raga buzghaia
  5. 5. History 2000: Dental pulp stem cells discovered by a researcherat the National Institutes of Health.2003: National Institutes of Health announces viablestem cells are in dental pulp of teeth.2004 to present: Over 1,000 published studiesidentifying therapeutic potential of dental mesenchymalstem cells.2008: Surgeons from Spain announced the world’s firsttissue-engineered whole organ transplantprocedure, using a trachea made with the patient’s ownadult mesenchymal stem cells.6/23/20135by Raga buzghaia
  6. 6.  2009: Scientists from Italy announced the first-everhuman clinical application using patients’own dental stem cells to repair mandibular bonedefects. 2011 : a study showed that stem cells from teeth cancreate islet- like cells which produce insulin ( apotential therapy for type 1 diabetes ) .6/23/20136by Raga buzghaia
  7. 7. 6/23/20137by Raga buzghaia
  8. 8.  Dental stem cells are present in various dentaltissues , including both deciduous and permanentteeth .(periodontal ligament,Apical papilla, and dental follicle) .6/23/20138by Raga buzghaia
  9. 9. 6/23/20139by Raga buzghaia
  10. 10. Therapeutic potential6/23/201310by Raga buzghaia
  11. 11.  Pulp and tooth regeneration, Repairing craniofacial and Skeletal bone, Myocardial infarction (heart attack), Tissue ischemia, diabetes, spinal cordinjury, Muscular dystrophy, stroke, cornea repair, Liver disease, Alzheimer’s and Parkinson’s disease.6/23/201311by Raga buzghaia
  12. 12.  Studies showed the role of stem cell and guidedtissue regeneration in periodontal treatment , inmaking of Bio-tooth , in regenerating pulp like tissuefor regenerative endodontics , in dental implantologyand in regeneration of craniofacial structure .6/23/201312by Raga buzghaia
  13. 13.  Dental pulp stem cellsstem cells derived from the dental pulp can formpulp like tissue , in future it is possible to replaceinfected pulp tissue of a paining tooth with newlygenerated pulp like tissue instead of doing RCT ,thuspreserving the vitality of the tooth “ regenerativeendodotics “ .It also has the ability to form bone that is useful forthe osseointegration of dental implants, thusincreaseing its success rate .6/23/201313by Raga buzghaia
  14. 14.  Stem cells of Human Exfoliated Deciduous Teeth- have higher rate of proliferation- have potential to form bone which is usefu duringosseointegration of dental implants- have the potential to repair calvarial defects inimmunocompromised mice .6/23/201314by Raga buzghaia
  15. 15.  Periodontal Ligament Stem Cells- have potentials of regenerating typical cementumand periodontal ligament like structure .- tissue of the periodontium made by stem cell canbe used as a treatment modality to replace thediseased periodontium around teeth so astreatment to mobility of teeth .6/23/201315by Raga buzghaia
  16. 16.  Stem Cells from Apical Papilla- can only be isolated at certain specific stages ofthe development of tooth.- dental papilla contain higher number of adultstem cells than mature dental pulp, thus have agreater potential for regenerating dentin thanDPSCs6/23/201316by Raga buzghaia
  17. 17.  Dental Follicle Precursor Cells-dental follicles contain progenitor cells which havethe capability of differentiating into cementumforming cells (cementoblasts), osteoblasts of thealveolar bone, and periodontal ligament fibroblasts.6/23/201317by Raga buzghaia
  18. 18. Conclusion As the research in thisfield continuing on withpromising future , wemay be able – in the nearfuture – to implant a biotooth primordium into apatient’s gum in theplace of a removed orlost tooth.6/23/201318by Raga buzghaia
  19. 19.  After implantation, itwould grow, form rootsthat would attachthemselves to thejaw, and eventually eruptinto the mouth after onlyfew weeks.6/23/201319by Raga buzghaia
  20. 20.  Although many studies have to be conductedbefore applying such therapeutic modalities,the dental stem cells represent a powerful toolwhich holds a significant potential for advancementin the field of regenerative dentistry and medicine.6/23/201320by Raga buzghaia
  21. 21. References review article : Therapeutic Potential of Stem cells in RegenerativeDentistry; a Review of Literature by Rizwan Abdul Rasheed Shaikh.“ INTERNATIONAL DENTAL JOURNAL OF STUDENT’S RESEARCH| Feb2013-May 2013| Volume 1| Issue 4 “. Review article : Dental Stem Cells and Their Potential Role in RegenerativeMedicine by Mohamed Jamal,, Sami Chogle,Harold Goodis and Sherif M. Karam . www.dentalaegis.com6/23/201321by Raga buzghaia
  22. 22. 6/23/201322by Raga buzghaia