1. Life Sciences Technology Solutions
Overview Brochure
BETTERTREATMENTS
THROUGH
DISCOVERY
RESEARCH AND
2. We are helping improve human and environmental health.
PerkinElmer is a global leader focused on improving the health and safety
of people and the environment. Our dedicated team of 7,700 employees
worldwide are committed to providing the technologies and expertise
needed for scientists and researchers, enabling them to gain critical
insights and discoveries in environmental monitoring, food quality &
nutrition, pharmaceutical development & manufacturing, lifesciences &
diagnostics.
Serving:
• Environmental & Applied Markets • Life Sciences • Diagnostics
FOR PEOPLE
FOR THE PLANET
FOR THE BETTER
By the numbers
1937 PerkinElmer Founded
150 Countries we serve
3300 US and
International Patents
MORE THAN
Amount of air, soil, and
water samples analyzed
using our solutions.
2.25
BILLION
Trace element samples
analyzed by our new
ICP-MS systems.
150
MILLION
Organic chemical
samples tested with our
chromatography systems.
50
MILLION
Novel therapeutic drugs
whose development was
enabled by our technologies.22
Cell samples analyzed in one
year on Opera®
High Content
Screening Systems.
50MILLION
Terabases of genetic data
sequenced by PerkinElmer DNA
Services to date (5 times more
data than in the print collection
of the U.S. Library of Congress).
52
MILLION
Every day, we help to reveal
serious disorders in newborns.
55
BABIES
Babies screened worldwide to
date for a variety of lifethreatening
diseases, elping them get off to a
healthier start.
450
MILLION
We touch over one million lives
every year through our advances
in digital imaging technology en-
abling cancer treatment systems.
ONE
MILLION
Environmental Life Sciences Diagnostics
3. APPLICATIONS
TECHNOLOGIES
Target Discovery
Accurately identify disease-relevant
targets and thoroughly validate each one
to ensure downstream success in your
drug development.
From cancer to infectious disease
research, advanced microscopic imaging
and analysis techniques help scientist
to visualize and quantify biology in
the context of individual cells, cell
populations and complex tissues.
Our solutions for biotherapeutics
researchers ensure the consistent,
reproducible results that your analytical
and patient safety considerations
demand. GLP-compliant processes in
the world’s leading pharmaceutical,
biotechnology and contract research
organizations and a large number of their
drugs have been approved for treatment
of patients with cancer, inflammatory
disease, and multiple rare diseases.
Quickly and accurately assess genomic
diversity within a population or disease-
related genetic variation through rapid
analysis of DNA markers with our
comprehensive genotyping solutions.
High throughput sample prep &
extraction Rapid RNA/DNA quantitation
Customized complex Integrated
automation
Genotyping
Quickly and accurately assess genomic
diversity within a population or disease-
related genetic variation through rapid
analysis of DNA markers with our
advanced genotyping solutions.
These solutions give human health
researchers valuable insights into human
disease states, and empower crop and
livestock farmers to increase quality,
yield, and sustainability.
Molecular Biology
Our state-of-the-art molecular biology
solutions are empowering a new wave
of experiments that unlock the secrets of
human development, normal physiology,
and disease like never before.
For every research involving monoclonal
antibodies (mAb) or proteins and
peptides, our wide portfolio of
immunogenicity, neutralizing antibody
(NAb) and PD/PK testing solutions can
streamline the workflow.
Small Scale Protein Purification, Whole
Genome, Exome, Targeted Amplicon
Sequencing, Epigenomics, Transcriptomics,
cDNA Synthesis, PCR/QPCR, Sample
Prep from FFPE, Genotyping, De Novo
Assembly and Detection of Structural
Variants, Cancer Biology Study, Stem Cell
Research, Neuroscience, Developmental
Biology, Protein Trafficking, Cellular
Microbiology of Pathogens, Cell Cycle
Chromatin Dynamics, Live Cell Imaging, 3D
Imaging, Plant Biology Studies, Multi Label
Detection, Gene Expression, Cytotoxicity
Profiling, Enzyme Kinetics, Pharmacological
Profiling, Quantitative Pathology etc.
• Automated Liquid Handling
• Microfluidics Technology
• High Content Screening
• High Throughput Screening
• Cellular Imaging Analysis Systems
• In Vivo Imaging
• Multi-Label Detection
• Radiometric Detection
• Microscopy and Tissue imaging
DRUG DISCOVERY DISEASE RESEARCH GENOMIC & GENOMIC RESEARCH
RESEARCH PATHOLOGY
Safety And Preclinical
BIOTHERAPEUTICS
The deep insights uncovered through
these analyses help researchers develop
more effective methods to predict and
monitor response to therapies and to
better understand diseases and their
recurrences.
4. High Content Screening
Operetta CLS™
The all-new Operetta CLS™
delivers
everything you need from high-content
analysis and more. For more complex
studies of primary cells, live cells, or cells cultured in 3D and
generate detailed phenotypic fingerprints for deeper biological
insights with high throughput and high resolution to capture
high-quality image data and the tools to turn that data into
knowledge. Whatever your application, there’s an Operetta
CLS system configured to meet your requirements. And
the system is modular, so it can change with your research
demands.
Opera Phenix™
With the Opera Phenix High Content
Screening System, simultaneous multicolor
confocal image acquisition delivers speed
without compromising sensitivity, because spectral crosstalk
is reduced to a minimum. The ideal high content screening
system for discriminating phenotypes and studying complex
disease models, such as primary cells and microtissues.
Spinning-disk optics and careful synchronization of laser
excitation and camera exposure minimize bleaching and photo
toxicity. Proprietary automated water-immersion objectives
with very high numerical aperture deliver and capture more
photons and provide higher resolution in XYZ. For day to
day applications to most demanding and high through put
applications the Opera Phenix High throughput screening
provides advantage of advance optics and Harmony optics.
Instrumentation HTS & HCS
High Through-put Screening
VICTOR™
The VICTOR™
X is the latest series of best-
in-class detection instruments designed for
running cost effective cellular assays and
screening technologies. These multilabel,
multitask plate readers run multiple assay
technologies on a single platform and are designed to support
your lab’s current and future demands. VICTOR X instruments
deliver flexibility, speed and performance to research labs of
all sizes, whether in academic centers, pharmaceutical and
biotech screening labs, drug discovery groups, or disease and
therapeutic area research groups.
EnSpire®
PerkinElmer new configurable multi label
Plate reader with quad monochromator
fluorescence intensity and absorbance.
The EnSpire®
cellular and biochemical
label-free platform combines the acclaimed performance of
Corning®
Epic®
technology with label-free patented biosensor
microplates.
EnVision™
For HTS applications, the EnVision plate
reader’s lower detection levels increase
confidence. EnVision instruments can read
a 96-well plate in less than 20 seconds
and a 1536-well plate in less than a
minute - providing a significant increase in throughput. The
EnVision platform accepts all standard microplates-including
96-, 384-, 1536- and 3456-well formats. It supports all main
non-radiometric technologies with kinetic and scanning
measurements, bottom-reading and a wide range of filters
and dichroic mirrors. Powerful software makes it easy to
take advantage of all the performance and versatility of the
EnVision platform.
EnSight®
The EnSight system’s cell-imaging option,
provided by the well-imaging module,
brings image-based cytometry together.
Fluorescence and Absorbance A quad-monochromator
for fluorescence and absorbance enables you to select any
wavelength and perform scans.
Plate Readers
PerkinElmer offers plate readers with a wide range of modes to meet the diverse application requirements of any lab. Each
multimode detection plate reader features leading technologies, so no matter which instrument you choose, you can expect
excellent performance for your specific application:
5. FMT®
In-Vivo Imaging System
The FMT®
imaging system is the
leading platform for quantitating
a broad range of in vivo imaging
biomarkers, disease pathways
and therapeutic response levels in
vivo. The benefits of fluorescence
tomography over 2D planar fluorescence include the ability
to detect deeper fluorescent sources, improved localization of
functional biology, quantitation of fluorophore concentration
or cell number count, and co-registration with other
tomographic imaging modalities including bioluminescence,
MRI, PET, SPECT and CT. It provides internal calibrations for
PerkinElmer agents.
Quantum GX microCT Imaging
System
The Quantum GX microCT multispecies
imaging system provides high-resolution
images at an X-ray dose low enough
to enable true longitudinal imaging
capability. With scan times as low as
8 seconds, the Quantum GX supports
a workflow of up to 30 subjects per hour, with acquisition,
reconstruction, and 3D visualization in under one minute.
This imaging system also comes with a user-friendly software
package for advanced bone analysis, The Quantum GX is
most suitable for applications including, pulmonary disease,
cardiovascular disease, diabetes, orthopedics and dentistry.
Imaging Systems
IVIS®
SpectrumBL High-Throughput In Vivo Bioluminescence Imaging System
Spectrum BL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of
bioluminescence, chemiluminescence and Cerenkov in vivo imaging.
Bioluminescence & Fluorescence in – Vivo Imaging
IVIS®
Lumina Series Imaging Systems
PerkinElmer provides an expandable,
sensitive imaging system that is easy to use
for both fluorescence and bioluminescence
imaging in vivo. The system includes
a highly sensitive CCD camera, light-
tight imaging chamber and complete
automation and analysis capabilities. As
the leading optical imaging platform for in vivo analysis, IVIS
systems include a range of practical accessories developed
through experience in research laboratories worldwide.
IVIS®
Spectrum Advanced Pre-
clinical Optical Imaging
The IVIS®
Spectrum advanced pre-clinical
optical imaging system combines high
throughput and full tomographic optical
imaging in one platform. The system
uses leading optical imaging technology to facilitate non-
invasive longitudinal monitoring of disease progression, cell
trafficking and gene expression patterns in living animals.
IVIS®
Lumina XRMS Series III Optical
& X-Ray Imaging System
The Lumina XRMS Series III offers the
newest technology on the market for
industry leading bioluminescence, low dose
X-Ray imaging and ultra -sensitive two
dimensional in vivo fluorescence imaging.
With the Lumina XRMS, get an anatomical
context to optical signal in mice and rats
and other large species.
IVIS®
Spectrum CT Integrated Optical
and Micro CT System
IVIS SpectrumCT offers bioluminescent,
Cerenkov and fluorescent imaging for
true quantitative and calibrated analysis
of optical data. With exquisitely sensitive
and unique optical detection technology
and spectral unmixing, the IVIS Spectrum
CT can identify very small optical sources within an animal.
Additionally, Cerenkov luminescence enables the optical
detection of positron emission tracers enabling translational
pharmacodynamic and pharmacokinetic studies
6. Radiometric detection
Gamma Counters Micro Fluidics TechnologyLiquid scintillation Analyzers
WIZARD2®
Automated Gamma
Counters
With the expanded WIZARD2 family
of automatic gamma counters, you
can have outstanding sensitivity
together with the highest-level
security, connectivity and ease of
use, giving you greater command
over your gamma counting process
LabChip®
GXII Touch Protein
Assay Portfolio
The LabChip®
Touch platform is a
chip based micro CE, quantitates
DNA, RNA and protein samples
for purity ,glycan and mAb charge
heterogeneity analysis. LabChip®
DS
UV-Vis micro-volume spectropho-
tometer for spectral quantification
of nucleic acid and protein samples,
with low volumes (2uL)
Tri-Carb®
Low Activity Liquid
Scintillation Analyzer
The Tri-Carb®
is a computer-controlled
bench top liquid scintillation analyzer
for detecting small amounts of alpha,
beta and gamma radioactivity. There
are variants available as per the
applications.
Tri-Carb 4810TR, Tri-Carb 4910TR &
Tri-Carb 5110TR
MicroBeta2
MicroBeta2, the latest version of
PerkinElmer’s industry-leading
MicroBeta®
line, adds new and improved
capabilities for researchers engaged in
all major radiometric and luminescence
applications.
Quantulus™
GCT 6220
A premium instrument for multiuser labs
that perform environmental and routine
counting for research applications.
Especially well-suited for environmental applications
the variant of the system is ideal for radiocarbon dating
uranium measurements in drinking water, Strontium in
food, monitoring of radioactivity during decommissioning of
nuclear reactors, tracer measurements in oil exploration.
MicroBeta2 LumiJET
The brilliant new capabilities of MicroBeta2
LumiJET to work with GPCRs, kinases,
reporter gene assays or traditional liquid
scintillation counting, it’s the platform that
delivers superior sensitivity and performance
MicroBeta Filtermate Universal
Harvester
Simple simultaneous harvesting of
samples from 96- and 24-well microplates
Harvesting cells is fast and easy with
PerkinElmer’s FilterMate™
Universal
Harvester. Our compact system harvests and washes all 96
or 24 samples simultaneously from shallow- or deepwell
microplates. The FilterMate Harvester is available in several
versatile configurations. There are FilterMate models suited
for either our MicroBeta®
or TopCount®
Scintillation and
Luminescence Counters, as well as a model designed for
cutting filtermats for our Tri-Carb®
Liquid Scintillation Counters
or WIZARD®
Automatic Gamma Counters.
7. Cell Imaging Systems
Tissue Imaging Products
Nuance®
–
Multispectral Imaging
System
Multiplexed labeling
achieved while retaining
intact morphology,The
Nuance system enables imaging of
multiple molecular markers in tissue
sections for both fluorescence and bright
field, even when they are co-localized
eliminate problems stemming from the
presence of auto fluorescence.
MantraTM
-
Quantitative
Pathology &
Imaging Analysis
The Mantra™
quantitative pathology workstation, with
in Form®
image analysis software, enables
easy visualization, quantification and
phenotyping of multiple types of immune
cells simultaneously. The Mantra can be
used with a variety of biomarker reagents
for multiplexed imaging in cancer research
and immunological applications.
Vectra®
3-Quntitiative
Pathology
and Analysis
The new Vectra®
, the
most advanced instrument for extracting
proteomic and morphometric informa-
tion from intact tissue sections. Vectra is
now compatible with AQUA from His-
toRx®
, providing validated, quantitative
tissue. Vectra merges automated slide-
handling, multispectral imaging, and
unique pattern recognition- based image
analysis. This system accurately measures
protein expressions and morphometric
characteristics in distinct tissue regions.
8. Consumables and Accessories
ALPHA Technology
GPCR & Frozen Cells
Luminescence Reagents
DELFIA®
LANCE®
Our Alpha Technology is part of a complete solution that
includes a comprehensive assay platform, Alpha-certified
detection, automation instrumentation, and custom assay
development. It’s everything you need to ensure consistent,
reproducible results.
Alpha (amplified luminescent proximity homogeneous assay)
is a versatile, bead-based platform that gives you the power
to assay even the most complex samples – all in one well,
with no wash steps.
Choice of over 300 GPCR targets and ion channel cell lines
validated off the shelf are available. Our cell lines typically
have saturation and competition binding data along with at
least one functional assay (agonist/antagonist dose response
curve using reference ligands). Most suited for Academic
departments, Biotech, Pharmaceutical Companies, CRO.
Lites Reagents for Cell-Based Assays:
Our lites are stored at 4°C which means they are ready to use
right away and provide good stability. They also don’t contain
DTT, making them safer for use in your lab.
Reporter Gene Assays
• Britelite™
plus – ultra-high sensitivity luciferase reporter gene
assay system
• Neolite™
– high sensitivity luciferase reporter gene assay
system. Designed for an extended signal half-life of > 2.5
hours.
• Steadylite plus™
high sensitivity luciferase reporter gene assay
system. Designed for a longer half-life of 4 hours.
Cytotoxicity/Cell Proliferation Assays
PerkinElmer offers two options for Adenosine TriPhosphate
(ATP) monitoring. Both systems are based on firefly (Photinus
pyralis) luciferase.
• ATPlite - two additions for maximal signal stability
• ATPlite 1step - homogeneous, single addition format.
Reagents for Western Blotting
The Western Lightning™
Chemiluminescence Reagent Plus is a
non-radioactive light-emitting system designed to detect pro-
teins immobilized on a membrane. (Guaranteed for 12 months
from shipment)
DELFIA®
is a proven, robust immunodetection platform
based on time-resolved Fluorescence (TRF) detection. This
detection method, coupled with the unique chemical
properties of lanthanide chelates, makes DELFIA a
superior alternative to conventional ELISA for research,
drug discovery and clinical applications. DELFIA offers a
combination of high sensitivity, wide dynamic range and
long-lasting stability that traditional ELISA cannot match.
The best TR-FRET technology and our proven, cost-effective
LANCE®
technology with new; enhanced LANCE Ultra.
Proven High Throughput Screening Technology for:
1) Kinase assays 2) Peptide-protein interaction assays
3) Nuclear Receptor assays 4) GPCR analysis 5) Protease
assays 6) Small & large molecule inhibitor screening.
9. AlphaLISA kits for Biomarkers and Cytokines
AlphaLISA no-wash immunoassays, as well as our
complementary DELFIA®
and LANCE assay platforms, ensure
that your immunoassays perform as sensitively, efficiently, and
accurately as your research requires – in half the time of ELISA.
Available for Autophagy, Biologics and Bioprocesses, Cancer,
Cardiovascular, CNS, Inflammation, Metabolic and virology.
MICROPLATES
All of our microplates are manufactured using the highest
quality plastics. They deliver important benefits such as low
background, optimum light transmission and little or no
crosstalk. We also provide custom coating, bar coding and other
specialized services. Footprint dimensions meet the SBS industry
standard, guaranteeing compatibility with microplate-based
instrumentation and Pinch bar design facilitates manual and
automated processing using robotic systems for high throughput.
Immunogenicity Testing
At PerkinElmer, we share your com-
mitment to answering challenging
biological problems. Our broad portfolio
of light based detection solutions and
expertise empower you to do more.
We offer the right combination of tech-
nologies to deliver more physiologically
relevant results and enhance your lab’s
productivity and efficiency.
Alpha Technology Toolbox Beads for
Immunogenicity Testing
• Alpha Screen Detection kits
• AlphaScreen IgG (Protein A)
• Fusion Tag
• Alpha Donor Beads
• AlphaScreen Acceptor Beads
• Delfia Plates and reagents
• ELAST®
ELISA amplification kits
ELAST®
: Save resources while
increasingELISA signals
The ELAST®
p24 ELISA Amplification
System improves the sensitivity of Alliance
HIV 1 p24 ELISA kits by approximately
25-fold while extending the dynamic
range of the assay.
Radiochemicals
PerkinElmer radiochemicals are used by researchers in a wide variety of scientific applications. These reagents are amenable to
kinetic and mechanistic studies, in addition to detection, quantitation, and screening.
Radionuclides:
Radionuclides are commonly used
in protein labeling, cell labeling, and
metabolic assays. They can be used as
tracers for cellular uptake and cytotoxic-
ity. PerkinElmer offer a broad choice of
radionuclides at various specific activities
and radioactive concentrations.
Radioimmunoassay (RIA) Kits:
Radioimmunoassay (RIA) continues to be
a useful and sensitive method of analyzing
and quantitating small molecules, pep-
tides, and proteins in biological samples.
Fully-validated 3H and 125I RIA kits that
contain all reagents required to run all
your assays, as well as a broad offering of
radiolabeled compounds applicable to RIA
are available from PerkinElmer.
The available reagents and services:
• Amino Acids & Derivatives,
Carbohydrates
• Chemical Precursors & Other
Compounds
• Custom Radiosynthesis & Radiolabeling
Services
• Iodinated Compounds, Ligands, Lipids
Nucleotides, Scintillation Proximity
Assay (SPA) & Steroids
10. Sample processing & Automation
Software & Informatics solutions
Automated Workstations
JANUS®
G3 Varispan Automated
Workstation
The JANUS®
G3 Automated Workstation
offers multiple pipetting technologies on a
single instrument platform. The instrument
consists of a modular platform that expands with flexible
4- or 8-tip Varispan™
arm, providing an automated liquid
handling solution with flexibility in throughput, plate capacity,
and dynamic volume range Technology®
(MDT) for adding
samples,compounds, beads and reagents.
JANUS®
G3 NGS Express
Workstation
PerkinElmer offers a wide array of
liquid handling instruments and custom
integration solutions to support and guide
your research while increasing your efficiency and precision.
The JANUS G3 NGS Express™
performs library prep for
benchtop sequencers. NGS Express enables preparation of up
to 24 libraries and supports applications of various kinds.
Zephyr G3 SPE®
Workstation
Zephyr G3 SPE Workstation is a powerful
workstation dedicated specifically for
high throughput SPE. Designed to
simultaneously process 96 samples with it’s
96 channel high volume head, the Zephyr
G3 SPE workstation can process one plate in approximately
30 minutes. A powerful tool for automating the critical steps
required in SPE and to meet the needs of clinical, forensic, and
pharmaceutical/biotech laboratories.
cell:explorer™
Automated Platform
Complete HTS automation for drug
discovery and stem cell research in a
temperature controlled environment. The
integrated cell:explorer genotyping platform
provides walkaway automation for all genotyping processes –
everything from DNA extraction and normalization to PCR plate
preparation and real-time PCR – all in a compact, space-saving
format.
Software & Informatics Solutions
Volocity Software
Volocity 3D Image Analysis Software
enables you to make discoveries and
answer complex questions that are beyond
the limitations of 2D. Moving seamlessly
among restoration, visualization and
quantitation, Volocity software is designed for true 3D
analysis of fluorescence images. It Measure shapes, volumes
and distances. Relate cellular structure to function with
exceptional precision and speed.
ChemDraw®
The chemical drawing industry
leader includes stereochemistry
recognition and display, Chem NMR
with spectral prediction and display,
and Name=Structure to interconvert
structures and IUPAC names. Now also
available on iPad®
.
Harmony®
High-Content Imaging and
Analysis Software
Harmony provides a complete solution
with all the tools you need to set up
assays and automate your high content
imaging experiments, acquire images and analyze data and
then store, retrieve and present the results. Designed for
biologists, Harmony’s workflow-based interface makes the
whole process of high content analysis straightforward,
even for new users with little microscopy or programming
knowledge.
TIBCO Spotfire®
Analytics platform
Spot fire empowers
scientists to explore their data freely: to
visualize instantly, mashup, interact with,
and share data at any level of detail. The
software helps users answer pressing
questions, uncover answers to questions
they didn’t know they had, and anticipate
what happens next, without requiring
special queries from IT.
E-Notebook for Biology
E-Notebook provide support
for diverse and complex
biological workflows such
as cell line development,
screening, upstream and downstream
processing, in vivo studies and other
discovery and development steps.
Researchers are able to transition endpoints
of these workflows between departments,
thus facilitating cross functional
collaboration across operational silos.
11. Service Support
• Pre-installation checks
• Installation & Commissioning
• Training
• Warranty support
• Annual maintenance
• Qualification services
Instrument Service
& installation
Team based consultative
approach for every
application need.
Support teams, comprised
of dedicated lab- and field-
based applications specialists,
to work with the customers.
Application
Support
• Comprehensive suite of
protocols
• Metrology and calibration
sources
• Computer validation
Qualification and
Validation
• Consulting and
benchmarking
• Lab IT
• Informatics solutions
Lab Efficiency
solutions
PerkinElmer is recognized worldwide for advanced instrumenta-
tion systems and outstanding customer
support. We continue to be your partner in life science research
providing instruments for scintillation, gamma, and microplate
counting; quantitative imaging and liquid handling. We are com-
mitted to providing the best instrument application support, field
service, and telephone support. We are proud of our tradition
of working with laboratories to accelerate the pace of life science
research.
