Glusterfs uses an asynchronous programming model where each component (xlator) calls into the next using STACK_WIND, passing a callback. The next xlator performs its task and then callbacks the original using STACK_UNWIND. This non-blocking approach prevents any xlator from blocking on network operations. Key data structures like the call_frame track the asynchronous call and callback between xlators, maintaining a stack. Debugging information within frames helps track errors like frame loss or stuck operations.