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1. Electron Transport and
Oxidative Phosphorylation
Dr. Pooja Parmar

2. Oxidative Phosphorylation
A. Oxidation step: electron transport chain
B. Phosphorylation step
NADH + H+ + O2
NAD+ + H2O
1
2
FADH2 + O2
1
2
FAD + H2O
ADP + Pi ATP

3. Figure 1. Mitochondria structure and position of electron
transport chain.

4. NADH dehydrogenase Succinate
dehydrogenase
Cytochrome c
oxireductase
Cytochrome c oxidase
Matrix
Fe-S
Fe-S
FMN
Iron
sulfur
centre
Q
Cyt c
Figure 2. General layout of the electron transport chain.

5. Figure. 3 Summary of electron transport chain
FADH+H+ FAD+

6. Figure 4. Overview of glycolysis.

7. Figure 5. Overview of Citric acid cycle.

8. 2NADH
2NADH
6 NADH
2FADH2
Figure 6. Fate of high energy electron carriers.

9. Figure 7. Oxidation of NADH and electron transfer in complex I .
H+ H+ H+
H+

10. Figure 8. electron transfer from ubiquinol to complex III

11. Figure 9. Overall electron transport chain.

12. Figure 5. Overview of Citric acid cycle.

13. Figure 10. Oxidation of FADH2 and electron transfer in
complex I .

14. Figure 11. Proton gradient formation and ATP synthesis.

15. Figure 12. ATP Synthase and different subunits.

16. Figure 13. Binding change mechanism of ATP synthase.

17. Figure 14. ATP synthesis.
ATP

18. ATP
4 H+ = 1 ATP
1 NADH = 10 H+
Therefore ,1 NADH = 10/4 = 2.5 ATP
Similarly 1 FADH2 = 6 H+
Hence, 1FADH2 = 1.5 ATP
Figure 14. Complete scheme of oxidative phosphorylation

19. Thank you