clinical reasearches prooved that cell based therapy can be considered as an important alternative for burn wound management. Know all facts and benefits here visit, https://www.cordlifeindia.com/

1. The Use of Stem Cells in Burnt Wound Treatment

2. Introduction
• Nearly half a million people, from across the
world, seek medical help for accidental burns
and are hospitalised in severe conditions.
These are fatal burns, often causing death.
However, there are many other kinds of burns,
which may leave the patients physically
disabled for their entire lifetime.

3. What are Burns?
Burns are therefore, accidental skin cell damages
brought on by fire, chemicals, electricity or
radiation, leaving the skin:
• terribly pained,
• swelled and
• charred.
Treatments for burn wounds depends upon the
type of the burn and how deep it is covering the
body.

4. Conventional Burn Wound Care
• A medical health practitioner always follows
the thumb rule of cleaning the burnt area first
with cool water and then applying gel upon it.
However, use of autologous skin grafting
technique was the first known severe burn
wound treatment, reported in 1881.
• Until now skin grafting technique happens to
be a standard practice to treat severe burnt
cases.

5. Conventional Burn Wound Care
• Earlier, in severely burnt cases (full-
thickness burn or 3rd degree burn, which
damages the epidermis and the entire
dermis), doctors discarded and considered
the burnt skin to be a medical waste.
• However, since it contains viable MSCs
(burnt-derived Mesenchymal Stem Cells),
that can be used for skin regeneration and
wound-healing, in present times these
cells are characterised and expanded in
vitro, which is then incorporated into an
established wound coverage material.

6. Introduction of Cell-Based Burn Wound Therapy
• In is interesting to know that the culture of
cell-based therapy for burn wounds was first
introduced after Rheinwald and Green,
revolutionised the cell culture technique in
1975. So, for the very first time, clones of
some of the major cell types was used during
an autograft, where epithelial sheets of cells
were produced to restore the functional
capacity of the skin.

7. Research Activities on Burn Wounds Cell Therapy
• Such an encouraging report gave rise to
worldwide research activities on cell
therapy for burn wounds healing process.
For example, a Singapore-based biotech
company Cell Research Corporation,
carried out a test which involved growing
stem cells on synthetic scaffolds, preventing
three burn victims from undergoing the
painful process of skin grafting. Several
tissue engineering approaches have been
applied in skin-tissue fabrication and tissue
substitute including autologous split-
thickness skin graft. Autograft micro-skin
transplantation has been widely used as
skin-graft therapy in full-thickness skin
defect.

8. Aim of Cell-Based Therapy in Burn Wound Care
The effectiveness of stem cell therapy in burn
wounds have already been tested earlier. With
further examination, the stem cell therapists
ultimately aimed to see:
• If these cells have the capacity to reduce the
effect of the systemic inflammatory response
and stop the infection from spreading
• An easy and early wound closure
• Speedy healing

9. Aim of Cell-Based Therapy in Burn Wound Care
• Regeneration of the skin and its peripheral
tissues
• See if the potential usage of Epithelial stem
cells (EpSCs) with an effective application of
Mesenchymal Stem Cells (MSCs), derived
from the umbilical cord and cord blood,
covers the wound and completes the healing
and skin regeneration process.

10. Epithelial Stem Cell Therapy on Burn Wound Cover
To prove an early and efficient wound coverage
along with the satisfactory epithelialization,
cultured epithelial autografts, (EpSCs and
keratinocytes combined) is used to facilitate cell
delivery with the aim to regenerate the epidermal
layer of the burned skin.
But there are several factors that limit the
potentially of this technique:

11. Epithelial Stem Cell Therapy on Burn Wound Cover
• the time necessary to culture cells
• the reliability of graft ‘take’
• the vulnerability to infection,
• long-term durability, and
• the cost of the treatment.

12. Mesenchymal Stem Cell therapy for Burn Wound Healing
Post-burn injury wound healing is of
paramount importance and allogeneic
mesenchymal stem cells (MSCs) is one of
the potential treatments for severe burn
injuries:
• MSCs can grow easily
• They can maintain the tissue culture
• They can migrate to support the
endogenous cells
• Additionally, its immunomodulation
capacity allows it to withstand acute
cellular rejection, especially in massive
burnt wounds

13. Future Directions
• However, researches state that when burn
wounds are treated with allogenic MSCs,
the recovery is speedy and there are no
adverse treatment complications.
• Clinical studies demonstrate that cell-based
therapy can be considered as an important
alternative for burn wound management.
However, there are still certain scientific
and technical factors that need to be
resolved before full potential of the cellular
devices are facilitated. In the meantime,
more evidence is required for research at
large to define the clinical efficacy and
safety of cell therapy in burns.

14. About CordlifeIndia
• CordlifeIndia provides services like stem cell banking, cord blood stem cell
banking.
• CordlifeIndia is a consumer healthcare company catering to the mother and child
segment.
• We provide reliable healthcare solutions through innovation, technological
advancement and commitment to quality.

15. References:
• https://www.cordlifeindia.com/blog/use-stem-cells-burnt-wound-treatment/
• http://my.clevelandclinic.org/health/diseases/12063-burns
• http://blog.medstarwashington.org/2017/06/05/research-burn-care-stem-
cells/#:~:text=A%20major%20problem%20in%20burn,and%20help%20them%20heal%20faster
• http://ncbi.nlm.nih.gov/pmc/articles/PMC5971426/
• https://cells4life.com/stem-cells-to-help-burns-victims-case-study/
• http://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1465-9