details about the all cells involved in the immune systems activities. Granular: Neutrophils, Eosinophils, Basophils and all Agranular cells.

1. Presented By
Dr. Narendra A. Manwar
Department of Zoology
Mahatma Phule Arts and Science College, Patur
Cells in the Immune
System
CLASS- B.Sc. III SEM- VI

2. Cells
in
the
Immune
System

3. WBC (Leucocytes)
These are of two types – I) Granular & II) Agranular
I) Granular:
1) Neutrophill:
Multilobed nucleus
Cell which reaches
at the site of infection
Phagocytosis
Lymphocyte trafficking

4. 2) Eosinophill:
 Bilobed Nucleus with granules.
 Acts as a phagocytic cell.
 Eosinophill granule may damage the parasitic
membrane.
 Plays a role in hypersensitivity reaction

5. 3) Basophill:
 These are nonphagocytic granulocyte
 Releasing pharmacologically active substance from
their granules
 Plays important role in allergic reactions

6. II) Agranular:
1) Lymphocytes:
a) T-lymphocytes: Originated from bone
marrow.
Maturation activation & proliferation in thymus.
i) TH-Cell: It consists of CD4
+ & MHC-II
molecule receptor.
It secrets cytokines & acts on B-cell to secrete
antibodies.
ii) TC-Cell: It consists of CD8
+ & MHC-I
molecular receptor.
It secrets toxin substance. Cell lysis.
iii) TS-Cell: It consists of CD25
+ & MHC-II
molecular receptor.
It suppresses immune response.
T-supressor cell

7. Memory T-Cell Formation:

8. a) B-lymphocytes:
1) Origin, maturation, development & proliferation takes
place in bone marrow.
2) Firstly found in gland viz. Bursa of Fabricus in birds.
3) Produces memory cell & plasma cell.
4) Secrete various type of antibodies.

9. Memory B-Cell Formation:

10. Monocyte & Macrophages:
Monocyte: Phagocytosis, lymphocyte
stimulation.
Macrophages:
•Monocytes circulate in blood at 8-10hr.
•Enter into particular tissue & get mature called macrophage.
•Phagocytosis by engulfing or by
•capturing the antigen.
•Also secrete cytokin.
•Intestinal macrophage – Gut
•Alveolar macrophage – Lung
•Histocytes macrophage – Connective T.
•Kupffer Cell – Liver
•Mesangial Cell - Kidney

11. Dendritic Cell:
 Long membranous extension resemble with
dendrites of nerve cell.
 Phagocytosis
 Lymphocyte stimulation

12. Natural Killer Cell:
 Small population of large granul.
 Exhibits cytotoxic activity specifically about
tumour cell.
 It expresses CD16
+ membrane receptor
 ADCC (antigen dependent cell mediated
cytotoxicity

13. Mast Cell:
 Mast cell precursor present in bone marrow.
 Differentiation & maturation takes place when it
enter in particular tissue.
 Secrete large number of cytoplasmic granules
contain histamine.
 Plays important role in development of allergies.

14. REFERENCES
1) Immunology by Kuby
2) Immunology by Abbas Abbas