This document discusses the various tissues and structures of the body. It describes the skin, superficial fascia, deep fascia, mucous membranes, serous membranes, ligaments, tendons, synovial sheaths, and tension lines. The skin is the outermost covering and largest organ, consisting of two layers - the epidermis and dermis. The superficial fascia lies beneath the skin and stores fat. Deep fascia invests muscles and forms intermuscular septa. Mucous and serous membranes line internal cavities. Ligaments attach bone to bone, tendons attach muscle to bone, and synovial sheaths envelop tendons at friction points. Tension lines influence skin creases
A brief description of human skin structures and barriers. Its include elaborate description of skin structure and basics of skin barriers which prevent or control the trans dermal drug delivery.
The integumentary system is the physical system that forms the barrier between the external environment and the internal systems of the body. In humans, this system consists of skin, hair, nails, and related glands.
Altogether, the integumentary system forms the largest organ in the body. The main function of this system is to protect bones, organs, and other internal structures from harm. In addition, the integumentary system performs important immune functions, cell fluid maintenance, synthesis of Vitamin D, body temperature regulation, and detection of stimuli.
A brief description of human skin structures and barriers. Its include elaborate description of skin structure and basics of skin barriers which prevent or control the trans dermal drug delivery.
The integumentary system is the physical system that forms the barrier between the external environment and the internal systems of the body. In humans, this system consists of skin, hair, nails, and related glands.
Altogether, the integumentary system forms the largest organ in the body. The main function of this system is to protect bones, organs, and other internal structures from harm. In addition, the integumentary system performs important immune functions, cell fluid maintenance, synthesis of Vitamin D, body temperature regulation, and detection of stimuli.
SKIN SENSORY ORGANThe human skin is the external covering of the .pdfsutharbharat59
SKIN :SENSORY ORGAN
The human skin is the external covering of the body. In people, it is the biggest organ of the
integumentary framework. The skin has up to seven layers of ectodermal tissue and watches the
hidden muscles, bones, tendons and inside organs. Human skin is like that of most different
warm blooded creatures. Despite the fact that about all human skin is secured with hair follicles,
it can seem bald. There are two general sorts of skin, bristly and glabrous skin. The descriptive
word cutaneous truly signifies \"of the skin\" . Since it interfaces with the earth, skin assumes an
essential insusceptibility part in securing the body against pathogens[3] and over the top water
loss. Its different capacities are protection, temperature direction, sensation, blend of vitamin D,
and the insurance of vitamin B folates. Extremely harmed skin will attempt to recuperate by
framing scar tissue. This is frequently stained and depigmented. In people, skin pigmentation
shifts among populaces, and skin sort can go from dry to slick. Such skin assortment gives a rich
and various living space for microorganisms that number around 1000 species from 19 phyla,
exhibit on the human skin
Skin has mesodermal cells, pigmentation, for example, melanin gave by melanocytes, which
ingest a portion of the possibly risky bright radiation (UV) in daylight. It additionally contains
DNA repair compounds that switch UV harm, with the end goal that individuals without the
qualities for these chemicals endure high rates of skin malignancy. One shape prevalently
delivered by UV light, threatening melanoma, is especially intrusive, making it spread rapidly,
and can frequently be dangerous. Human skin pigmentation shifts among populaces in a striking
way. This has prompted to the order of people(s) on the premise of skin color. The skin is the
biggest organ in the human body. For the normal grown-up human, the skin has a surface zone of
between 1.5-2.0 square meters (16.1-21.5 sq ft.). The thickness of the skin shifts significantly
over all parts of the body, and amongst men and ladies and the youthful and the old. A case is the
skin on the lower arm which is all things considered 1.3 mm in the male and 1.26 mm in the
female. The normal square inch (6.5 cm²) of skin holds 650 sweat organs, 20 veins, 60,000
melanocytes, and more than 1,000 nerve endings. The normal human skin cell is around 30
micrometers in distance across, yet there are variations. A skin cell more often than not extends
from 25-40 micrometers (squared), contingent upon an assortment of variables. Skin is made out
of three essential layers: the epidermis, the dermis and the hypodermis .Epidermis, \"epi\"
originating from the Greek signifying \"over\" or \"upon\", is the peripheral layer of the skin. It
shapes the waterproof, defensive wrap over the body\'s surface which likewise serves as a
hindrance to disease and is comprised of stratified squamous epithelium with a hidden basal
lamina.
The epiderm.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
Structure of integument in vertebrates shows same basic plane. It comprises two basic layers, that is outer epidermis (ectodermal in origin) and inner dermis (mesodermal origin).
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
SKIN SENSORY ORGANThe human skin is the external covering of the .pdfsutharbharat59
SKIN :SENSORY ORGAN
The human skin is the external covering of the body. In people, it is the biggest organ of the
integumentary framework. The skin has up to seven layers of ectodermal tissue and watches the
hidden muscles, bones, tendons and inside organs. Human skin is like that of most different
warm blooded creatures. Despite the fact that about all human skin is secured with hair follicles,
it can seem bald. There are two general sorts of skin, bristly and glabrous skin. The descriptive
word cutaneous truly signifies \"of the skin\" . Since it interfaces with the earth, skin assumes an
essential insusceptibility part in securing the body against pathogens[3] and over the top water
loss. Its different capacities are protection, temperature direction, sensation, blend of vitamin D,
and the insurance of vitamin B folates. Extremely harmed skin will attempt to recuperate by
framing scar tissue. This is frequently stained and depigmented. In people, skin pigmentation
shifts among populaces, and skin sort can go from dry to slick. Such skin assortment gives a rich
and various living space for microorganisms that number around 1000 species from 19 phyla,
exhibit on the human skin
Skin has mesodermal cells, pigmentation, for example, melanin gave by melanocytes, which
ingest a portion of the possibly risky bright radiation (UV) in daylight. It additionally contains
DNA repair compounds that switch UV harm, with the end goal that individuals without the
qualities for these chemicals endure high rates of skin malignancy. One shape prevalently
delivered by UV light, threatening melanoma, is especially intrusive, making it spread rapidly,
and can frequently be dangerous. Human skin pigmentation shifts among populaces in a striking
way. This has prompted to the order of people(s) on the premise of skin color. The skin is the
biggest organ in the human body. For the normal grown-up human, the skin has a surface zone of
between 1.5-2.0 square meters (16.1-21.5 sq ft.). The thickness of the skin shifts significantly
over all parts of the body, and amongst men and ladies and the youthful and the old. A case is the
skin on the lower arm which is all things considered 1.3 mm in the male and 1.26 mm in the
female. The normal square inch (6.5 cm²) of skin holds 650 sweat organs, 20 veins, 60,000
melanocytes, and more than 1,000 nerve endings. The normal human skin cell is around 30
micrometers in distance across, yet there are variations. A skin cell more often than not extends
from 25-40 micrometers (squared), contingent upon an assortment of variables. Skin is made out
of three essential layers: the epidermis, the dermis and the hypodermis .Epidermis, \"epi\"
originating from the Greek signifying \"over\" or \"upon\", is the peripheral layer of the skin. It
shapes the waterproof, defensive wrap over the body\'s surface which likewise serves as a
hindrance to disease and is comprised of stratified squamous epithelium with a hidden basal
lamina.
The epiderm.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
Structure of integument in vertebrates shows same basic plane. It comprises two basic layers, that is outer epidermis (ectodermal in origin) and inner dermis (mesodermal origin).
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
3. SKIN
OUTERMOST COVERING OF BODY
LARGEST ORGAN OF BODY
THICKNESS OF SKIN VARIES FROM 0.5 TO 3.0 mm
TOTAL SURFACE AREA ON AVERAGE IS 1.5 TO 2.0 sqm
CONSISTS OF 2 LAYERS
1.SUPERFICIAL LAYER OR EPIDERMIS
2.DEEP LAYER OR DERMIS
5. FUNCTIONS OF SKIN
PROTECTION
ABSORPTION
EXCRETION
TEMPERATURE REGULATION
SYNTHESIS OF VIT D
RECEPTOR
6. SUPERFICIAL FASCIA
IT LIES JUST BENEATH THE SKIN AND IS ALSO CALLED
HYPODERMIS OR SUBCUTANEOUS TISSUE
MADE UP OF LOOSE AREOLAR TISSUE
IT IS OF VARIABLE THICKNESS
THICKEST IN THE SCALP,PALMS,SOLES
THINNEST IN EYELIDS & NIPPLES
7. FUNCTION OF SUPERFICIAL FASCIA
CONNECT WITH DEEP FASCIA & BONES
SPACE FILLING AND PADDING STRUCTURE
SITE FOR STORAGE OF FAT
INSULATING LAYER
8. DEEP FASCIA
MEMBRANE LIKE STRUCTURE OF FIBROUS TISSUE
ABSENT IN FACE
FUNCTIONS OF DEEP FASCIA
1. INVESTING LAYER
2. ENCLOSES NEUROVASCULAR BUNDLES,MUSCLES,GLANDS
3. FORMS LAMINA OF INTERMUSCULAR SEPTA
4. FORMS BANDS OF EXTENSOR, FLEXOR RETINACULUM
5. FIBROUS SHEATH OF FINGERS AND TOES
9. MUCOUS MEMBRANE
LINING OF INTERNAL BODY SURFACE OR CAVITY
THERE ARE 3 COMPONENTS OF MUCOUS MEMBRANE
1. EPITHELIUM
2. LAMINA PROPRIA
3. MUSCULARIS MUCOSAE
10. SEROUS MEMBRANE
LINING OF CLOSED BODY CAVITY
SINGLE LAYER OF EPITHELIUM CALLED MESOTHELIUM
CONSISTS OF 2 LAYERS
1. PARIETAL LAYER
2. VISCERAL LAYER
11. LIGAMENT
COMPOSED OF DENSE CONNECTIVE TISSUE
THEY ATTACH BONE TO BONE
THEY UNDERGO STRESS & STRAIN
IMPORTANT IN STABILITY OF JOINTS
IT IS RIGID & FLEXIBLE
12. TENDON
MADE UP OF COLLAGEN FIBRES
ATTACH MUSCLES TO BONES
SOMETIMES IT BECOMES FLATTENED TO FORM
APONEUROSIS
IT IS ESTIMATED THAT 1cm2 OF A TENDON CAN SUPPORT
1000kg WEIGHT
13. SYNOVIAL SHEATH
FIBROUS SHEATH ENVELOPING THE TENDONS AT REGIONS
OF FRICTION
CONSISTS OF 2 LAYERS
1. PARIETAL LAYER
2. VISCERAL LAYER
14. CLINICAL & APPLIED ANATOMY
TENSION LINES
DESCRIBED BY LANGER AS CLEAVAGE LINES
APPEAR DUE TO PATTERN OF COLLAGEN FIBRES
SKIN CREASES RUN PARALLEL TO THESE LINES
INCISIONS MADE ALONG THESE LINES HEAL WITH
MINIMUM SCARRING
15. SPRAIN
INJURY TO LIGAMENTS LEADING TO INTRACTABLE PAIN
SOME FIBRES ARE DAMAGED BUT CONTINUITY REMAINS
INTACT
OCCUR IN ATHLETES