methods of preperation of O-glycosides and their biological activity in 2015-18 resarch papers from ACS , Elsevier , Springer , wiley's onlinw library . koenigs knorr synthesis , protection method and one-pot methods.

2. Synthesis and Bioactivity

3. Astragalin
 3-O-glucoside of kaempferol
 Shows anti-oxidant, anti-tumor, anti-human
immunodeficiency virus (HIV), and anti-inflammatory
effects
 Low water solubility of astragalin limits its use.
 Cyclodextrin glucanotransferase (CGTase) enzyme with
maltose (G2) is used to improve AS water solubility and
physiochemical properties
Choung et al., 2017

5. Do-decyl-α-D-mannopyranoside
 Antimicrobial activity against gram positive bacteria
Staphylococcus aureus
 MIC value (min. inhibitory conc.) is 78 μg/mL
R= O(CH2)11CH3
a= SnCl4, alcohol, CH2Cl2, 16h
b= MeONa, MeOH, 16h
Yield=90%
Bilkova et al., 2015

6. Triazole-O-glycosides
 They are used as
 Fluorescence probes
 Anti-HIV
 Anti-allergic
 Anti-bacterial
 2,3,4,6-Tetra-O-acetyl-α-D-mannopyranosyl
trichloroacetimidate was used as the glycosyl donor

7. S. Dutta et al., 2016

8. Koenigs-knorr Synthesis
 C3-O-neoglycosides of digoxigenin are synthesized by 1-bromo
glycosyl donor and digoxigenin aglycone
 Anti-cancer activity

9. Li et al., 2017

11. Phyllanthusmin D
Anti-tumoral activity
Acetylmananthoside B
Liu et al., 2017

12. Anti-tuberculosis agent
2-((4-((2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyloxy)methyl)-1H-
1,2,3-triazol-1-yl)methyl)-quinoline
Dutta et al., 2016

13. References
 Choung, W. J., Hwang, S. H., Ko, D. S., Kim, S. B., Kim, S. H.,
Jeon, S. H., ... & Shim, J. H. (2017). Enzymatic synthesis of a novel
kaempferol-3-O-β-d-glucopyranosyl-(1→ 4)-O-α-d-glucopyranoside
using cyclodextrin glucanotransferase and its inhibitory effects on
aldose reductase, inflammation, and oxidative stress. Journal of
agricultural and food chemistry, 65(13), 2760-2767.
 Bilková, A., Paulovičová, E., Paulovičová, L., & Poláková, M.
(2015). Antimicrobial activity of mannose-derived
glycosides. Monatshefte für Chemie-Chemical Monthly, 146(10),
1707-1714.

14. References
 trifluoromethanesulfonate and metallic copper mediated syntheses of
1, 2, 3-triazole-O-and triazolyl glycoconjugates: consecutive
glycosylation and cyclization under one-pot condition. Tetrahedron
Letters, 57(29), 3086-3090.
 Ren, Y. C., Bao, Y. Z., Liu, J., Zhang, X. K., Zhang, Y. W., Sun, X.
L., ... & Tang, J. S. (2018). Synthesis of C3-Neoglycosides of
digoxigenin and their anticancer activities. European journal of
medicinal chemistry, 145, 252-262.
 Liu, L., Hu, Y., Liu, H., Liu, D. Y., Xia, J. H., & Sun, J. S. (2017).
First Total Synthesis of the Bioactive Arylnaphthyl Lignan
4‐O‐Glycosides Phyllanthusmin D and 4′′‐O‐Acetylmananthoside
B. European Journal of Organic Chemistry, 2017(25), 3674-3680.
 Dutta, S., Gupta, S. J., & Sen, A. K. (2016). Silver