1. 2013.5.18 전상귀

2. Introduction
Sophorolipids (SLs) are glycolipids produced by a selected number of
yeasts.
Sophorolipid has been shown anti- HIV drugs, and effective anti-cancer
agents
Sophorolipid may have immunomodulatory activity.

3. Material and method
Fermentation medium
glucose (100 g), yeast extract (10 g), urea (1 g), and oleic acid (40g)/L of
water.
Antimicrobial studies
Stain - E. coli ATCC 25922, S. aureus ATCC 29213, Klebsiella pneumoniae
ATCC 35657, Pseudomonas aeruginosa ATCC 27853, Streptococcus
pneumoniae ATCC 49619, and Proteus mirabilis ATCC 35659.

4. Result
E. coli and S. aureus were >512 μg/ml for most SL derivatives. and >128
μg/ml for 2 SL derivatives in ethanol vehicle.

5. Result
>128 μg/ml for 2 SL derivatives in ethanol vehicle.

6. Result
Antimicrobial activity of SLs using DMSO as a carrier. The MIC value was
defined as the lowest concentration that induced 90 % inhibition
Shah et al reported on the antibacterial activity of SLs in various
carbohydrate-containing media against a selection of Gram-positive and
Gram-negative bacteria.
SLs derivatives may function as immunomodulators for the treatment of
septic shock by cytokine downregulation.

7. Conclusion
SL derivatives may have a role as anti-inflammatory agents or
immunomodulators in septic shock or in chronic inflammatory conditions.
SLs might be useful as spermicidal, viricidal, or chemotherapeutic agents [1-
3] without affecting the host’s normal flora or promoting the development of
resistant bacteria.