Determine modes of inheritance for a set of phenotypes each of which is determined by genotypes at two independently assorting loci. The data come from an alien species of fly whose genetics is identical to that of earth flies. As part of your assignment, you must confirm your hypothesized modes of inheritance by applying a chi-square analysis. NOTE ABOUT DEGREES OF FREEDOM: In situations where the observed counts and the expected counts for a category are both 0, that category does not figure into the chi-square calculation, so that the degrees of freedom is reduced by one in such situations. The possible modes of inheritance are: (i) Autosomal recessive; (ii) Homozygous lethal (dominant); (iii) Sex-linked recessive. The Sex-linked recessive mode can only occur in females parents. Counts of phenotype pairs for the F1 generation give you clues as to the mode of inheritance of each phenotype. Good luck! ONE PHENOTYPE PER PARENT, TWO PHENOTYPES TOTAL For the Tratagorian Kumbus Fly, that lives on the planet Zeon, parental matings occur only among flies in which each parent has a disease phenotype at one locus and is wild-type at the other locus. Problem 1. A female with Flonasean eye shape mates with a male with Muppetrus eye color, producing the following counts: F1 Generation Males WT-WT Disease-WT WT-Disease Disease-Disease 485 0 0 0 Females WT-WT Disease-WT WT-Disease Disease-Disease 476 0 0 0 Solution F1 Generation Males WT-WT Disease-WT WT-Disease Disease-Disease 484 0 0 0 Females WT-WT Disease-WT WT-Disease Disease-Disease 489 0 0 0 Important: The second locus is autosomal. Female (Autosomal recessive, wt) x Male (wt, Autosomal recessive).

1. Determine modes of inheritance for a set of phenotypes each of which is determined by
genotypes at two independently assorting loci. The data come from an alien species of fly whose
genetics is identical to that of earth flies. As part of your assignment, you must confirm your
hypothesized modes of inheritance by applying a chi-square analysis. NOTE ABOUT
DEGREES OF FREEDOM: In situations where the observed counts and the expected counts for
a category are both 0, that category does not figure into the chi-square calculation, so that the
degrees of freedom is reduced by one in such situations. The possible modes of inheritance are:
(i) Autosomal recessive; (ii) Homozygous lethal (dominant); (iii) Sex-linked recessive. The
Sex-linked recessive mode can only occur in females parents. Counts of phenotype pairs for the
F1 generation give you clues as to the mode of inheritance of each phenotype. Good luck! ONE
PHENOTYPE PER PARENT, TWO PHENOTYPES TOTAL For the Tratagorian Kumbus Fly,
that lives on the planet Zeon, parental matings occur only among flies in which each parent has a
disease phenotype at one locus and is wild-type at the other locus. Problem 1. A female with
Flonasean eye shape mates with a male with Muppetrus eye color, producing the following
counts: F1 Generation Males WT-WT Disease-WT WT-Disease Disease-Disease 485
0 0 0 Females WT-WT Disease-WT WT-Disease Disease-Disease 476
0 0 0
Solution
F1 Generation Males WT-WT Disease-WT WT-Disease Disease-Disease 484 0 0 0 Females
WT-WT Disease-WT WT-Disease Disease-Disease 489 0 0 0 Important: The second locus is
autosomal. Female (Autosomal recessive, wt) x Male (wt, Autosomal recessive)