About 15% of ethanol that is ingested is metabolized first in the: A. Stomach B. Liver C. Small Intestine D. Brain Solution Answer: A. Stomach Explanation: The ingested alcohol when reaches stomach and intestine is absorbed (20% and 80% respectively) into the veins, which also connect to stomach and liver. The alcohol reaches the liver and is metabolized by enzymes, viz., alcohol dehydrogenase and aldehyde dehydrogenase. Liver is important metabolizer of alcohol, but stomach also plays important role in First pass metabolism of alcohol and play a significant role in alcohol metabolism.