In this slide, I will teach you about gram-positive cocci which streptococcus agalactiae. I will tell you about its diseases, transmission, pathogenesis, characteristics, lab diagnosis, treatment, and prevention in a short and easy way.

2. Streptococcus Agalactiae
GROUP B STREPTOCOCCUS

3. Diseases
Neonatal meningitis
(8–28 postnatal days)
Pneumonia
(Inflames air sac in lungs)
Local skin and soft tissue infection
Sepsis
Infective endocarditis

4. Habitat & Transmission
Habitat
Vagina and colon
Transmission
During child birth

5. Pathogenesis
Pyogenic infections
Invasive infections
Poly saccharide capsule
Protect a bacterial cell from ingestion and
destruction by white blood

6. Predisposing factors
Heavy colonization of genital tract by this bacteria.
Absense of maternal antibody
Premature infant
Labor prior to 37 weeks, mostly before 3 week
Repture of the amniotic membrane
More than 18h before delivery.

7. Characteristics
Gram positive cocci in chains
Poly saccharide capsule
B hemolytic colonies
Difference antigenicity of cell wall
carbohydrates.
Complete lysis of RBCs
Lancefield group B

8. Laboratory Diagnosis
 Gram stain smear and culture (Crystal violet)
 Catalase negative (H2O2 into H2O and O2) all
 Bacitracin resistant ( No zone of inhibition)
 Blood agar, B hemolytic narrow colonies
 Increase hemolysis when plate with Staph aureus
 CAMP positive test (arrowhead zone of hemolysis with blood agar)
 Hydrolyze hippurate (hippurate into glycine and benzoic acid by
hippuricase enzyme)
 Culture at 35 weeks of pregnancy (collect sample from cotton swab from
vagina or rectum.

10. Treatment
Pencillin G
To intrapartum mother.(During childbirth)

11. Prevention
No vaccine
Ampicillin to mother
If prolong rupture of membrane occurs.
If mother has a fever
If premature infant

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