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Clostridium Botulinum Bacteria | Clinical Bacteriology | Microbiology Lecture
- 3. CNS DISEASES • Botulism • Descend paralysis, Flaccid paralysis due loose tone of muscles • Fatigue weakness, feeling tired • Vertigo, dry mouth and difficulty in swallowing and speaking due cranial nerve weakness • Paralysis or weakness of the face & chest muscles, limbs arms, and legs • Respiratory failure. • Ptosis, Drooping of the upper eyelid ,lazy eye due tired muscles cause blurred vision • Diplopia, Perception of 2 images of a single object
- 5. GIT DISEASES •Gastroenteritis, inflamation of intestinal mucosal membrane •Bloody diarrhea, blood in stool •Cramps involuntary contractions of muscle with pain •Infant botulism has been associated with ingesting raw honey
- 6. HABITAT & TRANSMISSION • Habitat • Soil • Transmission • Improperly preserved food • Cane food • Vegetables preserve in jar • Preserved string beans • Improper Cooked food
- 7. PATHOGENESIS • Spores to survive When failure to sterilize food during preservation • Spores germinate in anaerobic environment and produce toxin • Toxin is heat labile Therefore food eaten without proper cooking implicated GIT symptoms • Botulinum toxin, Exotoin have protease that cleaves snare protein involved release of acetylcholine at myoneuronal
- 8. CHARACTERISTICS •Gram positive rod •Obligate anaerobic (Absense of O2) •Spore forming
- 9. LABORATORY DIAGNOSIS •Serum or stool or in food Check toxin •Serological tests detection of toxin as antitoxin or antibody or production of disease in mice but not useful
- 10. TREATMENT •Antitoxin to type a,b, and e made in horses •Respiratory support for respiratory failure •Penicillin G or metronidazole
- 11. PREVENTION •Proper food preserving techniques •Proper canning cooked food •Discarding bulging cans •Cooking all home canned food
- 12. BUNDLE OF THANKS Subscribe our youtube channel for this lecture and for other medical and health related videos. Click herehttps://youtube.com/channel/UC6wpLe CKNqTOLGfRXHFz_Aw