HEMOLYTIC ANEMIA (pathophysiology & cf

1. PATHOPHYSIOLOGY AND
CLINICAL FEATURES OF
HEMOLYTIC ANEMIA
PRESENTED BY:-
MOUSHMI BISWAS

2. Hemolytic anemia = reduced
red-cell life span
•The normal red cell life is 110-120 days after
which the senile cells are removed by bone
marrow and spleenic macrophages.
•Reduced red cell survival leads to increased red
cell production due to erythropoietin drive that can
compensate for the reduced red cell life and
maintain a normal Hb level.
•The mean red cell life is affected by molecular
changes in either the red cell membrane or
haemoglobined red cell survival leads to.

3. How hemolysis occurs?
• Hemolysis occurs through two ways they
are-
1.INTRAVASCULAR HEMOLYSIS
2.EXTRAVASCULAR HEMOLYSIS
INTRAVASCULAR HEMOLYSIS EXTRAVASCULAR HEMOLYSIS
• PNH,TRANSFUSION RXN
• PHYSICAL / MECHANICAL
TRAUMA
• TOXIC MICROENVIRONMENT
• HEMOGLOBINOPATHIES
•ENZYMOPATHIES
•MEMBRANE DEFECTS
•MEGALOBLASTIC ANAEMIA
•AIHA
•DRUG INDUCED

4. HAEMOLYSIS PATHWAYS ARE OF
TWO TYPES

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8. COMPLICATIONS OF HA

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