The document summarizes the results of a study on the effects of CIRCOVAC vaccination on reproductive parameters in sows. The study was a blinded, controlled, randomized trial conducted on 3 German farms with a total of 250 vaccinated and 89 control sows. The results showed that vaccinated sows had significantly more live born and weaned piglets per sow than control sows. Specifically, vaccinated sows had 1.4 more live born piglets and 0.7 more weaned piglets per sow. Over the course of a year, vaccinated sows weaned 1.6 more piglets on average than control sows. The study confirms field experiences showing benefits of PCV2 sow vaccination on reproductive

1. CIRCOVAC  benefits on reproductive parameters Thaïs VILA, DVM MERIAL – Swine Technical Director EMEA

8. Results Low incidence of PCV2 infection (similar between groups) Mortality related to PMWS Lesion score at necropsy PCR Inguinal lymph nodes lesions Increase of serum antibodies level in sows, gilts and offspring provided by vaccination Serology and viremia in sows and offsprings Vaccinated group: 8.7% Control group: 9.5% Global mortality in offsprings

9. Results: live born piglets + 1.4 piglet / sow * p=0.007 14.0 1.0 3.4 10.1* 40 19.0 6.0 2.1 11.5* 124 Cycle 2 15.0 1.0 2.7 10.2 54 18.0 2.0 2.4 10.6 155 Cycle 1 Max Min   N Max Min   N Control CIRCOVAC

10. Results: weaned piglets/sow + 0.7 piglet / sow + 1.6 weaned / sow / year * p=0.027 13.0 1.0 3.3 8.6* 40 14.0 3.0 1.8 9.8* 124 Cycle 2 12.0 1.0 2.3 8.9 54 17.0 1.0 2.4 9.2 155 Cycle 1 Max Min   N Max Min   N Control CIRCOVAC

12. CIRCOVAC benefits at all stages

13. Thank you!