CAR T cell therapy involves reprogramming a patient's own T cells to recognize and kill cancer cells. The T cells are grown in laboratories and then infused back into patients. Some patients with lymphoma or leukemia have been cured or achieved remission after one treatment with CAR T cells when chemotherapy stopped working. While side effects can include sleepiness and confusion, CAR T cell therapy offers patients a healthier option to fight disease and extend their lives when other treatments have failed.

1. CAR T CELL THERAPY
TERMINAL DOES NOT HAVE TO MEAN DEATH

2. WHAT AREYOURT CELLS?
White
blood cells
• Circulate around our bodies
Killer and
HelperT
cells
• Controls immune response
Gladiators
of the
blood
• Eradicates cancer cells,
virally or bacterially
infected cells

3. DOWNSIDE / UPSIDE OF T CELLS
Remembers a germ encountered
years before
Creates anti-infection molecules
(antibodies)
Help other immune cells ingest
germs
Allergic reactions
Autoimmune diseases (such as
diabetes, RA, MS)
Rejects transplanted organs

4. WHAT ARE CART CELLS ?
CHIMERIC ANTIGEN RECEPTORS
• PATIENT’S OWN T CELLS
REPROGRAMEDTO RECOGNIZE
PROTEINS ON CANCER CELLS
• GROWN BYTHE BILLIONS IN
LABORATORIES
• INFUSED BACK INTOTHE PATIENT
• NEW ENGINEERED CART CELLS
RECOGNIZE AND KILL CANCER
CELLS

6. WHAT HAPPENS NEXT
• NEW CAR T CELLS GIVEN BACK TO PATIENT
• PATIENT’S BODY: CAR T CELLS MULTIPLE
• CART CELLS RECOGNIZE CANCER CELLS
(that harbor the antigen on their surfaces)

8. CAR T CELLS
CURED OR REMISSION: PATIENTSWITH
LYMPHOMA LEUKEMIA

9. WHY CONSIDER CAR T CELL THERAPY?
• SOMETIMES CURED AFTER ONE TREATMENT
• CHEMOTHERAPY STOPS WORKING
• HEALTHIER FORYOUR BODY:YOUR CELLS HELPYOUR BODY FIGHT DISEASE
• YOUWANT A LONGER LIFE –YOU HAVE OPTIONS!

10. CASE STUDIES
• In Britain, one of three types of non-Hodgkin lymphoma failed all other treatments. Most
patients live for six months but half of the trial group are still alive nine months since the
trial began, and a third may be cured.
• Dimas Padilla, 43, of Orlando, who was warned his case was worsening after
chemotherapy stopped working: now in complete remission after undergoing the
therapy last August.

11. SOME SIDE EFFECTS
• Typically only lasting a few days:
• Only13% developed immune system conditions creating anemia or other blood-count-related problems
SLEEPLINESS,
CONFUSION,
TREMOR,
DIFFICULTY
SPEAKING

12. WEWOULD LIKETOTHANK
• https://www.cancer.gov/about-cancer/treatment/research/car-t-cells
• https://www.cancer.org/treatment/treatments-and-side-effects/treatment-
types/immunotherapy
• https://www.msn.com/en-gb/health/medical/terminal-cancer-patients-in-complete-
remission-after-one-gene-therapy-treatment/ar-AAnEbNy
• www.aacr.org
• http://www.tcells.org/beginners/tcells/