• Immunotherapy is also sometimes called biologic therapy or biotherapy. It is treatment that uses certain parts of the immune system to fight diseases such as cancer• Stimulating your own immune system• Giving you immune system components• Cancer immunotherapy is the use of the immune system to reject cancer. The main premise is stimulating the patients immune system to attack the malignant tumor cells that are responsible for the disease.
CANCER IMMUNOTHERAY• In late 1800s Dr William Coley first noted that getting an infection after surgery seemed to help some cancer patients. he began treating cancer patients by infecting them with certain kinds of bacteria, which came to be known as Coley toxins.
Types of immunotherapy • Monoclonal antibodies a) Naked mAbs b) Conjugated mAbs i. Radiolabelled ii. Chemolabeled iii. immunotoxin • Cancer vaccines • Non-specific immune therapies a) Cytokines b) interleukin
Alemtuzumab + CD 52 against melanoma Before After
Cancer immunotherapy:Monoclonal antibodies[2 ] Brand Antibody mab type Type Target Approved treatment(s) name humanizeAlemtuzum ab Campath Naked mAB CD52 Chronic lymphocytic leukemia ddenileukin Chemolabeled humanize (Ontak®) CD25 colorectal cancerdiftitox mAB d ChemolabeledBrentuximab Hodgkin lymphoma,Anaplastic large- Adcetris chimeric CD30ssvedotin cell lymphoma mAB Radiolabel ledIbritumomab non-Hodgkin lymphoma(with yttrium- Zevalin murine CD20tiuxetan 90 or indium-111 mAB
LATEST RESEARCH• Newer Monoclonal Antibodies• In June 2008, it was announced that United States doctors from the Clinical Research Division led by Cassian Yee at Fred Hutchinson Cancer Research Centerin Seattle have for the first time successfully treated a skin cancer patient by using immune cells cloned from his own immune system which were then re-injected into him.• Topical immunotherapy• Imiquimod immune enhancement cream• Natural product• Agaricus subrufescens