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Management of Open Fracture
and Pathological Fractures
Department of Orthopaedics
What is meant by Open Fracture?
Classification
• Gustilo – Anderson
• Tscherene
• AO
Gustilo Type I
6
• Energy - Low
• Wound size - ≤1 cm
• Soft tissue damage - Minimal
• Contamination - Clean
• Fracture pattern - Simple fracture
with minimal comminution.
• Skin coverage - Local coverage
Gustilo Type II
7
• Energy - Moderate
• Wound size - 1-10 cm
• Soft Tissue Damage - Moderate
• Contamination - Moderate
contamination.
• Fracture pattern - Moderate
comminution
• Skin coverage - Local coverage
Gustilo Type IIIA
9
• Energy - High
• Wound size - Usually >10 cm
• Soft Tissue Damage - Extensive
• Contamination - Extensive
• Fracture pattern - Severe
comminution or segmental
fractures
• Periosteal striping - Yes
• Skin coverage - Local coverage
• Neurovascular Injury - Normal
Gustilo Type IIIB
10
• Energy - High
• Wound size - Usually >10 cm
• Soft Tissue Damage - Extensive
• Contamination - Extensive
• Fracture pattern - Severe
comminution or segmental fractures
• Periosteal striping - Yes
• Skin coverage - Requires free tissue
flap or rotational flap coverage.
• Neurovascular Injury - Normal
Gustilo Type IIIC
11
• Energy - High
• Wound size - Usually >10 cm
• Soft Tissue Damage - Extensive
• Contamination - Extensive
• Fracture pattern - Severe comminution
or segmental fractures
• Periosteal striping - Yes
• Skin coverage - Typically requires flap
coverage.
• Neurovascular Injury - Exposed fracture
with arterial damage that requires repair.
Treatment
• Goals
- Preserve Life
- Preserve Limb
- Preserve Function
Principles of treatment
• Antibiotic prophylaxis
• Wound debridement
• Fracture stabilization
Initial Management
• Patient assessment: ABC
• Rule out cervical injuries, chest, abdominal injuries, head injuries
in polytrauma patients.
• Identify skeletal injuries and obtain necessary radiographs
• IV Tetanus
• IV Antibiotics
Primary Surgery
• Objectives of initial surgical management
• Preservation of life and limb
• Wound debridement
• Definitive injury assessment
• Fracture stabilization
Debridement
• Most important step.
• Aim - Removal of dead tissue and foreign material to ensure
good blood supply.
• Debridement done as soon as possible. (within 6 hours of
initial injury)
• With delay risk of infection increases
Irrigation
• Usual irrigation fluid used is normal
saline
• High volume low pressure repeated
lavage is performed.
• Volume of fluid used varies- usually
about 3 L is used for grade 1 ; 6-10 L is
used for grade 2 or 3
Limb salvage and Amputation
• Limb is nonviable as evidenced by
• irreparable vascular injury
• warm ischemia time >8 hrs
• severe crush injury with minimal remaining viable tissue.
Skeletal Stabilization
• Done once vascular repair is completed and limb salvaged or
once irrigation and debridement is done.
• Restoring the length, rotational, and angular alignment has
many benefits for healing of soft tissues.
Wound Closure
• Wounds without skin loss: tension free primary closure after
thorough debridement.
• Contraindications for primary closure
• Delayed presentation >12 hrs.
• Deep seated contamination
• Nerve injury
• Inability to achieve tension free suture
• High risk of anaerobic contamination like farm yard injuries.
• Wounds with skin loss: healing by secondary intention. Delayed
primary closure, split skin grafts, free flaps
Pathological Fractures
• Pathologic fractures occur in abnormal bone.
• Weakened bone predisposes the patient for
failure during normal activity or after minor
trauma.
Systemic- non neoplastic
Correctable
• Renal osteodystrophy
• Hyperparathyroidism
• Osteomalacia
• Disuse osteoporosis
Uncorrectable
• Osteogenesis imperfecta
• Polyostotic fibrous dysplasia
• Postmenopausal
osteoporosis
• Paget disease
• Osteopetrosis
• Common metastatic
cancers-
– Breast
– Lung
– Prostate
– thyroid
– kidney
• Common sites of
metastasis-
– Spine
– Pelvis
– Ribs
– Skull
– proximal femur
– Proximal humerus.
Lab
• CBC
• ESR
• Electrolytes
• BUN
• Serum glucose
• Liver function tests
• Total protein
• Albumin
• Calcium, phosphorus,
and alkaline
phosphatase.
• Anemia, hypercalcemia, increased ALP-
widespread metastasis.
• Serum and urine electrophoresis- multiple
myeloma
• Microsopic hematuria- RCC
• TFT, CEA, CA-125, PSA.
• N-telopeptide and C-telopeptide are markers
of bone collagen breakdown measured in
serum and urine.
– Confirm increased destruction caused by bone
metastasis
– Measure the overall extent of bone involvement
Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Clin
Orthop Relat Res. 2003;(415):S138–S147.
Management considerations
• Treatment of local bone lesion-
• Surgical stabilisation +/- resection: large lytic
lesion at risk of fractures/pathologic fractures.
• Radiation: Adjuvant local treatment for entire
operative field.
• Functional bracing
• Bisphosphonates: inhibit osteoclast mediated
bone resorption.
Operative treatment
• Intramedullary device or modular prosthesis
provides better stability.
• Bone cement-
– Increases the strength of fixation
– Should not be used to replace segment of bone
• Goal should be to stabilize as much of the
bone as possible.
A 58-year-old man with a pathologic fracture of
the distal femur due to lung cancer

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Management of Open Fractures and Pathological Fractures

  • 1. Management of Open Fracture and Pathological Fractures Department of Orthopaedics
  • 2. What is meant by Open Fracture?
  • 3. Classification • Gustilo – Anderson • Tscherene • AO
  • 4.
  • 5.
  • 6. Gustilo Type I 6 • Energy - Low • Wound size - ≤1 cm • Soft tissue damage - Minimal • Contamination - Clean • Fracture pattern - Simple fracture with minimal comminution. • Skin coverage - Local coverage
  • 7. Gustilo Type II 7 • Energy - Moderate • Wound size - 1-10 cm • Soft Tissue Damage - Moderate • Contamination - Moderate contamination. • Fracture pattern - Moderate comminution • Skin coverage - Local coverage
  • 8.
  • 9. Gustilo Type IIIA 9 • Energy - High • Wound size - Usually >10 cm • Soft Tissue Damage - Extensive • Contamination - Extensive • Fracture pattern - Severe comminution or segmental fractures • Periosteal striping - Yes • Skin coverage - Local coverage • Neurovascular Injury - Normal
  • 10. Gustilo Type IIIB 10 • Energy - High • Wound size - Usually >10 cm • Soft Tissue Damage - Extensive • Contamination - Extensive • Fracture pattern - Severe comminution or segmental fractures • Periosteal striping - Yes • Skin coverage - Requires free tissue flap or rotational flap coverage. • Neurovascular Injury - Normal
  • 11. Gustilo Type IIIC 11 • Energy - High • Wound size - Usually >10 cm • Soft Tissue Damage - Extensive • Contamination - Extensive • Fracture pattern - Severe comminution or segmental fractures • Periosteal striping - Yes • Skin coverage - Typically requires flap coverage. • Neurovascular Injury - Exposed fracture with arterial damage that requires repair.
  • 12.
  • 13. Treatment • Goals - Preserve Life - Preserve Limb - Preserve Function
  • 14. Principles of treatment • Antibiotic prophylaxis • Wound debridement • Fracture stabilization
  • 15. Initial Management • Patient assessment: ABC • Rule out cervical injuries, chest, abdominal injuries, head injuries in polytrauma patients. • Identify skeletal injuries and obtain necessary radiographs • IV Tetanus • IV Antibiotics
  • 16. Primary Surgery • Objectives of initial surgical management • Preservation of life and limb • Wound debridement • Definitive injury assessment • Fracture stabilization
  • 17. Debridement • Most important step. • Aim - Removal of dead tissue and foreign material to ensure good blood supply. • Debridement done as soon as possible. (within 6 hours of initial injury) • With delay risk of infection increases
  • 18. Irrigation • Usual irrigation fluid used is normal saline • High volume low pressure repeated lavage is performed. • Volume of fluid used varies- usually about 3 L is used for grade 1 ; 6-10 L is used for grade 2 or 3
  • 19. Limb salvage and Amputation • Limb is nonviable as evidenced by • irreparable vascular injury • warm ischemia time >8 hrs • severe crush injury with minimal remaining viable tissue.
  • 20. Skeletal Stabilization • Done once vascular repair is completed and limb salvaged or once irrigation and debridement is done. • Restoring the length, rotational, and angular alignment has many benefits for healing of soft tissues.
  • 21.
  • 22. Wound Closure • Wounds without skin loss: tension free primary closure after thorough debridement. • Contraindications for primary closure • Delayed presentation >12 hrs. • Deep seated contamination • Nerve injury • Inability to achieve tension free suture • High risk of anaerobic contamination like farm yard injuries. • Wounds with skin loss: healing by secondary intention. Delayed primary closure, split skin grafts, free flaps
  • 24. • Pathologic fractures occur in abnormal bone. • Weakened bone predisposes the patient for failure during normal activity or after minor trauma.
  • 25. Systemic- non neoplastic Correctable • Renal osteodystrophy • Hyperparathyroidism • Osteomalacia • Disuse osteoporosis Uncorrectable • Osteogenesis imperfecta • Polyostotic fibrous dysplasia • Postmenopausal osteoporosis • Paget disease • Osteopetrosis
  • 26. • Common metastatic cancers- – Breast – Lung – Prostate – thyroid – kidney • Common sites of metastasis- – Spine – Pelvis – Ribs – Skull – proximal femur – Proximal humerus.
  • 27. Lab • CBC • ESR • Electrolytes • BUN • Serum glucose • Liver function tests • Total protein • Albumin • Calcium, phosphorus, and alkaline phosphatase.
  • 28. • Anemia, hypercalcemia, increased ALP- widespread metastasis. • Serum and urine electrophoresis- multiple myeloma • Microsopic hematuria- RCC • TFT, CEA, CA-125, PSA.
  • 29. • N-telopeptide and C-telopeptide are markers of bone collagen breakdown measured in serum and urine. – Confirm increased destruction caused by bone metastasis – Measure the overall extent of bone involvement Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Clin Orthop Relat Res. 2003;(415):S138–S147.
  • 30.
  • 31.
  • 32.
  • 33. Management considerations • Treatment of local bone lesion- • Surgical stabilisation +/- resection: large lytic lesion at risk of fractures/pathologic fractures. • Radiation: Adjuvant local treatment for entire operative field. • Functional bracing • Bisphosphonates: inhibit osteoclast mediated bone resorption.
  • 34.
  • 35. Operative treatment • Intramedullary device or modular prosthesis provides better stability. • Bone cement- – Increases the strength of fixation – Should not be used to replace segment of bone • Goal should be to stabilize as much of the bone as possible.
  • 36.
  • 37. A 58-year-old man with a pathologic fracture of the distal femur due to lung cancer