Medicine

1. Hypolipidemic
drugs
Domina Petric, MD

2. HMG-CoA reductase (3-hydroxy-3-methyl-
glutaryl-coenzyme A reductase) inhibitors
• atorvastatinum
• simvastatinum
• rosuvastatinum
• fluvastatinum
• ...

3. Atorvastatinum (10 mg, 20 mg, 40 mg, 80 mg tbl.)
Indicated (with suitable diet) for lowering of:
• LDL-cholesterol
• apolipoprotein B
• triglycerides
IN adults, adolescents and children
(more than 10 years old) with primary
hypercholesterolaemia.

4. Atorvastatinum
Indicated for
prevention of
cardiovascular
incidents in adults
with high risk.

5. Dose:

6. Contraindications:
• hypersensitivity
• active liver disease
• three times or more elevation of serum
transaminases (from upper border of
normal levels)
• pregnancy and lactation
• generative women that do not take
contraception (risk for pregnancy)

7. Fibrates
• gemfibrozilum
• fenofibratum
• ...

8. Fenofibratum
Indications are:
• treatment of severe
hypertriglyceridemia with or without
low HDL-cholesterol levels
• mixed hyperlipidemia when statins are
contraindicated
• in addition with statins if necessary

9. Recommended daily dose:
145 mg per os
once a day

10. Contraindications:
• liver insufficiency
• gall blader diseases
• severe chronic kidney disease
• chronic or acute pancreatitis (exept if it
is caused with hypertriglyceridemia)
• fototoxic reaction on fenofibrat
• hypersensitivity

11. Other hypolipemics:
• omega-3 acidorum esteri
ethylici 90
• ezetimibum
• lomitapide
• ...

12. Literature: