Neuroinf

Institute for Microbiology, Medical Faculty of Masaryk University and St. Anna Faculty Hospital in Brno Agents of neuroinfections

Importance of central nervous system infections ,[object Object],[object Object],[object Object],[object Object]

Penetration into CNS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

E tiology of CNS infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Etiology of acute meningitis – I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Etiology of acute meningitis – II ,[object Object],~ (30-40) ↓ ( < 30) 40-80 mg/100 ml glucose ↑ (50-100) ↑↑ ( > 100) 20-50 mg/100 ml proteins ↑↑ (100-500) ↑↑↑ ( > 1000) 0-6/ μ l cells aseptic meningitis purulent meningitis norm marker

Etiology of acute meningitis – III ,[object Object],5-29 ≥ 60 30-59 1-4 y. 0-1 m. age 50 GBS

Etiology of acute meningitis – IV ,[object Object],5-29 ≥ 60 30-59 1-4 y. 0-1 m. age 70 50 Haem. infl. b GBS

Etiology of acute meningitis – V ,[object Object],45 5-29 ≥ 60 30-59 1-4 y. 0-1 m. age 70 50 Neiss. men. Haem. infl. b GBS

Etiology of acute meningitis – VI ,[object Object],45 5-29 ≥ 60 40 other 30-59 1-4 y. 0-1 m. age 70 50 Neiss. men. Haem. infl. b GBS

Etiology of acute meningitis – VII ,[object Object],45 5-29 50 ≥ 60 Str. pneu. 40 other 30-59 1-4 y. 0-1 m. age 70 50 Neiss. men. Haem. infl. b GBS

Etiology of acute meningitis – VIII ,[object Object],20 25 45 5-29 15 50 25 ≥ 60 10 List. mono. 33 10 Str. pneu. 40 33 other 30-59 1-4 y. 0-1 m. age 10 15 70 50 Neiss. men. Haem. infl. b GBS

Etiology of acute meningitis – IX ,[object Object],[object Object],† † letha-lity + List. mono. + Str. pneu. + other seque-lae impor-tance +++ Neiss. men. Haem. infl. b GBS

Etiology of acute meningitis – X ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Overview of Central-European neuroviruses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],* Preventable by vaccination

Arboviruses in Central Europe – I ? Uukuniemi ? Batai (Čalovo) + Coltivirus : Eyach + Alfavirus : Sindbis + Bunyaviridae : Ťahyňa + Orbivirus : Tribeč + WNV + Flavivirus : TBEV Antibodies only Disease Genus or family : arbovirus

Arboviruses in Central Europe – II ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

dengue v. (flavivirus, Greece) CCHFV (nairovirus, Ukraine, Bulgaria) Toscana v. (phlebovirus, Italy) Bhanja v. (bunyavirus, Slovakia) chikungunya v. (alphavirus)

Etiology of chronic meningitis ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.icu.cn

Cystic lesions resulting from accumulation of organisms in perivascular spaces aapredbook.aappublications.org

Etiology of encephalitis ,[object Object],[object Object],[object Object],[object Object],[object Object],Mumps parotitis with cervical and presternal edema and erythema

Etiology of acute brain abscess ,[object Object],[object Object],[object Object],[object Object]

http://www.pathology.med.ohio-state.edu

Etiology of chronic brain abscess ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

http :// www.medicine.cmu.ac.th Top: Taenia solium cysticerci in the brain of a nine-year-old girl who died during cerebrospinal fluid extraction to diagnose her headaches. This was in the 1970s - if it had happened 10 years later, noninvasive computerized tomography would have given an accurate diagnosis, and the parasites could have been killed with drugs. (Image courtesy of Dr. Ana Flisser, National Autonomous University of Mexico.) Left: A pork tapeworm ( T.solium ) cysticercus , the form in which the tapeworm is found in an infected brain. (Colorized image by P. W. Pappas and S. M. Wardrop, courtesy of P. W. Pappas, Ohio State University.) http://eands.caltech.edu/articles/LXVI4/brainworms.html

Homework 2 – solution Leonardo da Vinci (1452-1519): Fetus in the Womb (between 1510-1512)

Homework 3 Who painted this picture and what is its name?

Neuroinf

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