Brian Anthony MIT STEX Automation Workshop June 17, 2015

1. © 2015 B.W. Anthony, MIT
3 Points
1. Collaborate with MIT in
Manufacturing Innovation
and Entrepreneurship in
education.
2. Collaborate with MIT in
Medical Device Innovation
and Manufacturing in
research.
3. Data Analytics Parallels in
Manufacturing and
Healthcare.
Brian W. Anthony, PhD
Co-Director, Medical Electronics Device Realization Center
Director, Master of Engineering in Manufacturing Program
banthony@mit.edu

2. © 2015 B.W. Anthony, MIT
MIT
People in the Manufacturing Ecosystem
Company
MIT Students
Master of
Engineering in
Manufacturing
(MEngM)
Program
MIT Company
Your Employees
Medical
Electronics
Device
Realization
Center
(MEDRC)
Challenges, PerspectivesChallenges, Perspectives
Challenges, PerspectivesChallenges, Perspectives

3. © 2015 B.W. Anthony, MIT
MASTER OF ENGINEERING IN
MANUFACTURING (MENGM)
PROGRAM
How to Collaborate with MIT in

4. © 2015 B.W. Anthony, MIT
MengM Curriculum Elements
• Design and Manufacturing
– Design for Manufacturing
– Product Development Process
• Manufacturing Physics
– Processes, Machines, Assembly, Process
Control
• Manufacturing Systems
– Factory Design and Control
– Supply Chain Design and Control
• Management and Global Manufacturing
– Management for Engineers
– Seminar in Global Manufacturing
• Group Projects in Industry
Group Project
Individual Work
Team Work
Mfg.Physics
Mfg.Systems
Prod.Design
Business
Master of Engineering in Manufacturing (MEngM) Program

5. © 2015 B.W. Anthony, MIT
What is the MEng in Manufacturing?
• One Year, Non-Research Graduate Degree
• Comprehensive Design and Manufacturing
Curriculum
• Taken as a Cohort
• Emphasis on Using Engineering Background
• Introduction of the Systems Perspective
• Project-Based, and Team-Based Curriculum
• Strong Industry Connection
– 8 of 12 Months on Group Project in Industry.
Master of Engineering in Manufacturing (MEngM) Program

6. © 2015 B.W. Anthony, MIT
Group Projects
• Based in a Company
• Teams of 3-4 Students
• Solve Problem of Immediate
Value to Company and
Pedagogically Aligned with
the Degree
• During 8 of the 12 months of
program
• Project Definition is Critical
– Product and Process Design for a
Diagnostic Microfluidic Device
– Implementation of RFID (internet of
things) for Product and Equipment
Tracking in a Factory
– Process Development for a High
Volume Factory
– Supply Chain Planning for New
Products
– New Product Introduction (NPI)
manufacturing line development
– …
Examples
Master of Engineering in Manufacturing (MEngM) Program

7. © 2015 B.W. Anthony, MIT
MEDICAL ELECTRONIC DEVICE
REALIZATION CENTER (MEDRC)
How to Collaborate with MIT in

8. © 2015 B.W. Anthony, MIT
Hospitals,
Physicians
MIT
MEDRC Companies
MEDRC - Model
• Each sponsored project jointly created
by industry, academics, and clinicians
 maximizes chance of project
success.
• Industrial scientist on-site at MIT 
company stays engaged, project stays
relevant, technology transferred to the
company.
• Early prototypes placed in “customers”
(clinicians) hands in parallel with
research technology development.
Employees
Challenges, PerspectivesChallenges, Perspectives
MEDRC at MIT does Medical
Electronic Device Research with
strong interaction between
companies and physicians/clinicians.
Medical Electronic Device Realization Center (MEDRC)

9. © 2015 B.W. Anthony, MIT
Application Areas and Technology Examples
• Wearable Devices
– Vital signs monitors including cuffless blood pressure
• Minimally Invasive Monitors
– EEG measurements for Epilepsy patients
• “Point of Care” Instruments
– “Lab on a Chip” for blood, urine, saliva analysis
• Imaging
– Smart Ultrasound
• Data Communication
– Body Area Network
• Pharma
– Clinical trial of the future
Medical Electronic Device Realization Center (MEDRC)

10. © 2015 MIT, Brian W. Anthony
DATA ANALYTICS PARALLELS IN
MANUFACTURING AND HEALTHCARE

11. © 2015 B.W. Anthony, MIT
Acquire Analyze Distribute
Data:
Use
Sensors
Information for defined Needs:
Data, through Analytics, to
Actionable Information
Supply Chain
Factory
Machine,
Product
Data Analytics Parallels in Manufacturing and Healthcare

12. © 2015 B.W. Anthony, MIT
Acquire Analyze Distribute
Data:
Use
Sensors
Information for defined Needs:
Data, through Analytics, to
Actionable Information
Health Care System
Hospital
Patient
Data Analytics Parallels in Manufacturing and Healthcare

13. © 2015 B.W. Anthony, MIT
DATA ANALYTICS PARALLELS IN
MANUFACTURING AND
HEALTHCARE
Example: Volume Imaging for Process or Procedure Control

14. © 2015 B.W. Anthony, MIT
Volume Imaging for Process Control
ϴ
…
Height
(Z)
Direction of Scan (X)High Speed
Camera
3 DOF Stage
Objective
Lens
Height=50µmHeight=17µm
Height=0µmHeight=33µm
Dean Ljubicic, Brian Anthony
Data Analytics Parallels in Manufacturing and Healthcare

15. © 2015 B.W. Anthony, MIT
Volume Imaging for Procedure (Biopsy) ControlTylor Hess, Xian Du, Rahul Sheth, Anthony Samir, Brian
Anthony
Core biopsy specimens in
white light (top row) and NIR
(bottom row)
3D biopsy sample imaging
system.
Sample image at a sequence of
viewing angles
0º
45º
90º
135º
180º
Data Analytics Parallels in Manufacturing and Healthcare

16. © 2015 B.W. Anthony, MIT
DATA ANALYTICS PARALLELS IN
MANUFACTURING AND
HEALTHCARE
Example: Constellation Analysis for Process or Physical “Health”

17. © 2014 B.W. Anthony, MIT
Constellation Analysis for Process “Health”
200 400 600 800 1000 1200 1400 1600
200
400
600
800
1000
1200
1400
1600
50 100 150 200 250
50
100
150
200
250
Calculated Grid Deformation Map
xy
Known grid fit to noisy data
1 mm
Fluorescent
Image Carrier
Glass
Impression Cylinder
Camera
UV-
Illumination
Xian Du, Dave Hardt, Brian Anthony
Data Analytics Parallels in Manufacturing and Healthcare

18. © 2015 B.W. Anthony, MIT
Constellation Analysis for Skin Health
Mechanical scanning system to take
high resolutions images of skin
Image 1: Isometric View
of
Camera‐Light Mount
Image 2: Side View of
Camera‐Light Mount
Ina Kundu, Ian Lee, Xian Du, Brian Anthony
Data Analytics Parallels in Manufacturing and Healthcare

19. © 2015 MIT, Brian W. Anthony
Disease
Acuity
(Severity)
Cost
ER
Office visit
Home
Summary Need
$$$$$$
Degradation
of Condition
of Quality
Cost
Failure,
Shutdown
Monitor,
Maintenance
$$$$$$
Product Realization
(Design, Manufacturing, Support)
System
Healthcare
System
Data Analytics Parallels in Manufacturing and Healthcare

20. © 2015 B.W. Anthony, MIT
3 Points
1. Collaborate with MIT in
Manufacturing Innovation
and Entrepreneurship in
education.
2. Collaborate with MIT in
Medical Device Innovation
and Manufacturing in
research.
3. Data Analytics Parallels in
Manufacturing and
Healthcare.
Brian W. Anthony, PhD
Co-Director, Medical Electronics Device Realization Center
Director, Master of Engineering in Manufacturing Program
banthony@mit.edu
1. Company Based
Projects with the
MEngM Program
2. Company / Hospital /
MIT Projects in the
MEDRC
3. Data, through
Analytics, to Actionable
Information