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Mekanisme kerja
Efek steroid topikal pada berbagai sel di kulit adalah:
- Antiinflamasi
- Imunosupresif
- Anti-proliferatif
- Vasokonstriksi
Potensi steroid topikal
Potensi steroid topikal bergantung pada:
• Molekul spesifik
• Jumlah yang mencapai sel target
• Penyerapan melalui kulit (0,25% –3%)
• Formulasi
Tidak ada gunanya mengencerkan steroid topikal, karena potensinya
tidak banyak bergantung pada konsentrasi dan pengenceran produk
tidak akan mengurangi risiko efek samping.
Formulasi
Indikasi
Dermatosis yang responsif
terhadap steroid topikal
Dermatosis yang kurang responsif
terhadap steroid topikal
Dermatosis yang responsif
terhadap steroid intralesi
Psoriasis
Dermatitis atopic
Dermatitis seboroik
Neurodermatitis sirkumkripta
Dermatitis numularis
Dermatitis statis
Dermatitis venenata
Dermatitis intertriginosa
Dermatitis solaris
Lupus eritematosus discoid
Psoriasis di telapak tangan dan kaki
Nekrobiosis lipoidika diabetikum
Vitiligo
Granuloma anulare
Sarkoidosis
Liken planus
Pemfigoid
Eksantema fikstum
Keloid
Jaringan parut hipertrofik
Alopesia areata
Akne kistika
Prurigo nodularis
Morfea
Dermatitis dengan likenifikasi
Liken amiloidosis
Vitiligo (sebagian responsif)

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Steroid Topical in Dermatology 2.pptx

  • 1. Mekanisme kerja Efek steroid topikal pada berbagai sel di kulit adalah: - Antiinflamasi - Imunosupresif - Anti-proliferatif - Vasokonstriksi
  • 3.
  • 4. Potensi steroid topikal bergantung pada: • Molekul spesifik • Jumlah yang mencapai sel target • Penyerapan melalui kulit (0,25% –3%) • Formulasi Tidak ada gunanya mengencerkan steroid topikal, karena potensinya tidak banyak bergantung pada konsentrasi dan pengenceran produk tidak akan mengurangi risiko efek samping.
  • 6. Indikasi Dermatosis yang responsif terhadap steroid topikal Dermatosis yang kurang responsif terhadap steroid topikal Dermatosis yang responsif terhadap steroid intralesi Psoriasis Dermatitis atopic Dermatitis seboroik Neurodermatitis sirkumkripta Dermatitis numularis Dermatitis statis Dermatitis venenata Dermatitis intertriginosa Dermatitis solaris Lupus eritematosus discoid Psoriasis di telapak tangan dan kaki Nekrobiosis lipoidika diabetikum Vitiligo Granuloma anulare Sarkoidosis Liken planus Pemfigoid Eksantema fikstum Keloid Jaringan parut hipertrofik Alopesia areata Akne kistika Prurigo nodularis Morfea Dermatitis dengan likenifikasi Liken amiloidosis Vitiligo (sebagian responsif)